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New tests for the assessment of thyroid function in dogs

New tests for the assessment of thyroid function in dogs As the techniques of thyroid imagery are not suitable for use in veterinary practice, laboratory tests are of special interest in the confirmation of thyroid disease. As many thyroidal function tests exist for use in dogs, but all are controversial, we assessed two new tests which have recently been commercially developed: the canine TSH assay and the canine thyroglobulin autoantibody assay. The TSH values assayed with the DPC kit in dogs were usually under 0.55 ng/1. TSH assay could not totally replace thyroid stimulation with T4 measurement in hypothyroidism but permitted distinction between a thyroidal disease (high TSH) and an extrathyroidal disease (low TSH). TSH should be considered as complementary to thyroid stimulation for the determination of hypothyroidal aetiology. TSH measurement could also be used to confirm pituitary aetiology in nanism (TSH undetectable), and to evaluate the therapeutic efficacy of treatments of hypothyroidism with thyroidal aetiology, the dose being suitable when the TSH value returns to normal.The main aetiology of hypothyroidism seemed to be autoimmune lymphocytic thyroiditis. Thyroglobulin autoantibodies were the most frequent autoantibodies found in dogs with thyroiditis. It was not possible to use a commercial canine thyroglobulin autoantibody assay kit to refute or confirm this in a population of dogs with hypothyroidism and high TSH. Further technical developments will be required before the canine thyroglobulin autoantibody immunoassay can be used to diagnose thyroiditis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

New tests for the assessment of thyroid function in dogs

Siliart, B.; Stambouli, F.
Comparative Clinical Pathology , Volume 7 (3) – Sep 1, 1997
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References (54)

Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag London Limited 1997
eISSN
1433-2973
DOI
10.1007/bf02652594
Publisher site
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Abstract

As the techniques of thyroid imagery are not suitable for use in veterinary practice, laboratory tests are of special interest in the confirmation of thyroid disease. As many thyroidal function tests exist for use in dogs, but all are controversial, we assessed two new tests which have recently been commercially developed: the canine TSH assay and the canine thyroglobulin autoantibody assay. The TSH values assayed with the DPC kit in dogs were usually under 0.55 ng/1. TSH assay could not totally replace thyroid stimulation with T4 measurement in hypothyroidism but permitted distinction between a thyroidal disease (high TSH) and an extrathyroidal disease (low TSH). TSH should be considered as complementary to thyroid stimulation for the determination of hypothyroidal aetiology. TSH measurement could also be used to confirm pituitary aetiology in nanism (TSH undetectable), and to evaluate the therapeutic efficacy of treatments of hypothyroidism with thyroidal aetiology, the dose being suitable when the TSH value returns to normal.The main aetiology of hypothyroidism seemed to be autoimmune lymphocytic thyroiditis. Thyroglobulin autoantibodies were the most frequent autoantibodies found in dogs with thyroiditis. It was not possible to use a commercial canine thyroglobulin autoantibody assay kit to refute or confirm this in a population of dogs with hypothyroidism and high TSH. Further technical developments will be required before the canine thyroglobulin autoantibody immunoassay can be used to diagnose thyroiditis.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Sep 1, 1997

Keywords: Dog; TgAA; Thyroxine; TRH; TSH

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