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New insights into the origin of amyloid plaques

New insights into the origin of amyloid plaques research highlights NEURODEGENERATIVE DISEASE Lee, J-H. et al. Nat. Neurosci. 25, 688–701 (2022) Alzheimer’s disease (AD) is characterized by Here, Lee et al. generated a transgenic containing APP-βCTF/Aβ around the the presence of tau filaments in intracellular mouse line expressing a dual fluorescent nucleus, forming large membrane blebs neurofibrillary tangles and amyloid β (Aβ) sensor to monitor autophagy in neurons that resemble petals of a flower. This peptides in extracellular senile plaques. in vivo. The sensor (tfLC3), which is unique pattern, which was termed Extensive research is ongoing to understand composed of pH-resistant mRFP and PANTHOS (poisonous “anthos” (flower)) how, and when, Aβ plaques are forming pH-sensitive eGFP linked to LC3, a protein by the investigators, was detected in in AD brains. Using a new transgenic associated with autophagosomes (APs) and neurons of AD mice prior to plaque mouse line and five mouse models of AD, autolysosomes (ALs), produces different formation. a study in Nature Neuroscience shows that colors (yellow, orange or red) depending “We establish quantitatively that autophagy dysfunction in neurons precedes on the pH of the environment and the PANTHOS neurons are the origin of the the formation of amyloid plaques. These quenching of the GFP signal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Lab Animal Springer Journals

New insights into the origin of amyloid plaques

Le Bras, Alexandra
Lab Animal , Volume 51 (7) – Jul 1, 2022
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New insights into the origin of amyloid plaques

Abstract

research highlights NEURODEGENERATIVE DISEASE Lee, J-H. et al. Nat. Neurosci. 25, 688–701 (2022) Alzheimer’s disease (AD) is characterized by Here, Lee et al. generated a transgenic containing APP-βCTF/Aβ around the the presence of tau filaments in intracellular mouse line expressing a dual fluorescent nucleus, forming large membrane blebs neurofibrillary tangles and amyloid β (Aβ) sensor to monitor autophagy in neurons that resemble petals of a flower. This...
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Publisher
Springer Journals
Copyright
Copyright © Springer Nature America, Inc. 2022
ISSN
0093-7355
eISSN
1548-4475
DOI
10.1038/s41684-022-01007-x
Publisher site
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Abstract

research highlights NEURODEGENERATIVE DISEASE Lee, J-H. et al. Nat. Neurosci. 25, 688–701 (2022) Alzheimer’s disease (AD) is characterized by Here, Lee et al. generated a transgenic containing APP-βCTF/Aβ around the the presence of tau filaments in intracellular mouse line expressing a dual fluorescent nucleus, forming large membrane blebs neurofibrillary tangles and amyloid β (Aβ) sensor to monitor autophagy in neurons that resemble petals of a flower. This peptides in extracellular senile plaques. in vivo. The sensor (tfLC3), which is unique pattern, which was termed Extensive research is ongoing to understand composed of pH-resistant mRFP and PANTHOS (poisonous “anthos” (flower)) how, and when, Aβ plaques are forming pH-sensitive eGFP linked to LC3, a protein by the investigators, was detected in in AD brains. Using a new transgenic associated with autophagosomes (APs) and neurons of AD mice prior to plaque mouse line and five mouse models of AD, autolysosomes (ALs), produces different formation. a study in Nature Neuroscience shows that colors (yellow, orange or red) depending “We establish quantitatively that autophagy dysfunction in neurons precedes on the pH of the environment and the PANTHOS neurons are the origin of the the formation of amyloid plaques. These quenching of the GFP signal.

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Lab Animal – Springer Journals

Published: Jul 1, 2022

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