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Myosin motor function: the ins and outs of actin-based membrane protrusions

Myosin motor function: the ins and outs of actin-based membrane protrusions Cells build plasma membrane protrusions supported by parallel bundles of F-actin to enable a wide variety of biological functions, ranging from motility to host defense. Filopodia, microvilli and stereocilia are three such protrusions that have been the focus of intense biological and biophysical investigation in recent years. While it is evident that actin dynamics play a significant role in the formation of these organelles, members of the myosin superfamily have also been implicated as key players in the maintenance of protrusion architecture and function. Based on a simple analysis of the physical forces that control protrusion formation and morphology, as well as our review of available data, we propose that myosins play two general roles within these structures: (1) as cargo transporters to move critical regulatory components toward distal tips and (2) as mediators of membrane-cytoskeleton adhesion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular and Molecular Life Sciences Springer Journals

Myosin motor function: the ins and outs of actin-based membrane protrusions

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References (152)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Birkhäuser Verlag, Basel/Switzerland
Subject
Life Sciences; Biochemistry, general; Life Sciences, general ; Biomedicine general; Cell Biology
ISSN
1420-682X
eISSN
1420-9071
DOI
10.1007/s00018-009-0254-5
pmid
20107861
Publisher site
See Article on Publisher Site

Abstract

Cells build plasma membrane protrusions supported by parallel bundles of F-actin to enable a wide variety of biological functions, ranging from motility to host defense. Filopodia, microvilli and stereocilia are three such protrusions that have been the focus of intense biological and biophysical investigation in recent years. While it is evident that actin dynamics play a significant role in the formation of these organelles, members of the myosin superfamily have also been implicated as key players in the maintenance of protrusion architecture and function. Based on a simple analysis of the physical forces that control protrusion formation and morphology, as well as our review of available data, we propose that myosins play two general roles within these structures: (1) as cargo transporters to move critical regulatory components toward distal tips and (2) as mediators of membrane-cytoskeleton adhesion.

Journal

Cellular and Molecular Life SciencesSpringer Journals

Published: Jan 27, 2010

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