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Mutated mtDNA Distribution in Exponentially Growing Cell Cultures and How the Segregation Rate is Increased by the Mitochondrial Compartments

Mutated mtDNA Distribution in Exponentially Growing Cell Cultures and How the Segregation Rate is... A cell contains many copies of mitochondrial DNA. The distribution of a mitochondrial gene mutation in a cell culture is governed by the way in which the mtDNA molecules of a cell are replicated and partitioned between the two daughter cells during mitosis. Assuming that this partition process is random, we describe the evolution of the mitochondrial genetic state of a cell culture. The mutated mtDNA is ultimately segregated and the rate of the trend to segregation is relatively slow. It is nevertheless greatly accelerated if the model takes into account the spatial mtDNA partition by the mitochondrial compartments. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biotheoretica Springer Journals

Mutated mtDNA Distribution in Exponentially Growing Cell Cultures and How the Segregation Rate is Increased by the Mitochondrial Compartments

Reder, Christine
Acta Biotheoretica , Volume 49 (4) – Oct 26, 2004
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References (7)

Publisher
Springer Journals
Copyright
Copyright © 2001 by Kluwer Academic Publishers
Subject
Philosophy; Philosophy of Biology; Evolutionary Biology
ISSN
0001-5342
eISSN
1572-8358
DOI
10.1023/A:1014257923877
Publisher site
See Article on Publisher Site

Abstract

A cell contains many copies of mitochondrial DNA. The distribution of a mitochondrial gene mutation in a cell culture is governed by the way in which the mtDNA molecules of a cell are replicated and partitioned between the two daughter cells during mitosis. Assuming that this partition process is random, we describe the evolution of the mitochondrial genetic state of a cell culture. The mutated mtDNA is ultimately segregated and the rate of the trend to segregation is relatively slow. It is nevertheless greatly accelerated if the model takes into account the spatial mtDNA partition by the mitochondrial compartments.

Journal

Acta Biotheoretica – Springer Journals

Published: Oct 26, 2004

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