Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Kamal, Mohammed Syed, Shaheer Mohammed (2015)
Therapeutic potential of benzothiazoles: a patent review (2010 – 2014)Expert Opinion on Therapeutic Patents, 25
Bosco D'Sa, P. Kisanga, J. Verkade (2001)
P(MeNCH2CH2)3N: An Efficient Catalyst for the Synthesis of Substituted Ethyl Benzofuran-2-CarboxylatesSynlett, 2001
D. McQuade, P. Seeberger (2013)
Applying flow chemistry: methods, materials, and multistep synthesis.The Journal of organic chemistry, 78 13
J. Yoshida, A. Nagaki, Daisuke Yamada (2013)
Continuous flow synthesis.Drug discovery today. Technologies, 10 1
Richard Jones, Lajos Godorhazy, N. Varga, D. Szalay, L. Urge, F. Darvas (2006)
Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis.Journal of combinatorial chemistry, 8 1
Q. Chao, K. Sprankle, R. Grotzfeld, Andiliy Lai, T. Carter, A. Velasco, R. Gunawardane, Merryl Cramer, M. Gardner, J. James, P. Zarrinkar, H. Patel, S. Bhagwat (2009)
Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.Journal of medicinal chemistry, 52 23
Toshiyasu Suzuki, K. Tanemura, T. Horaguchi, T. Shimizu, T. Sakakibara (1992)
Benzofuran derivatives. Part 4 , synthesis of benzofurans and 2,3,4,5‐tetrahydro‐1‐benzoxepin‐3,5‐dionesJournal of Heterocyclic Chemistry, 29
Lucille Bozec, C. Moody (2009)
Naturally Occurring Nitrogen–Sulfur Compounds. The Benzothiazole AlkaloidsAustralian Journal of Chemistry, 62
(1975)
Preparation of condensed thiazoles as antibacterial
P. Abramenko, V. Zhiryakov, T. Ponomareva (1975)
Polymethine dyes — Furo[2,3-g]benzothiazole derivativesChemistry of Heterocyclic Compounds, 11
D. Kirschneck (2013)
Strategies for Using Microreactors and Flow Chemistry: Drivers and ToolsChemical Engineering & Technology, 36
M. Chakrabarty, Taraknath Kundu, S. Arima, Y. Harigaya (2005)
An expedient, regioselective synthesis of 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]indolesTetrahedron Letters, 46
P. Nussbaumer, P. Lehr, A. Billich (2002)
2-Substituted 4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase.Journal of medicinal chemistry, 45 19
Wim Snick, Y. Aibuldinov, W. Dehaen (2013)
An efficient synthetic route towards novel thienobenzothiazoles, thienobenzothiazepines, and thienobenzothiazinesTetrahedron, 69
Keith Korthals, W. Wulff (2008)
Traceless stereoinduction in the one-pot assembly of all three rings of hexahydrodibenzopyrans.Journal of the American Chemical Society, 130 10
N. Matsunaga, T. Kaku, F. Itoh, Toshimasa Tanaka, Takahito Hara, Hiroshi Miki, M. Iwasaki, T. Aono, M. Yamaoka, M. Kusaka, A. Tasaka (2004)
C17,20-lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors.Bioorganic & medicinal chemistry, 12 9
S. Venkatraman, F. Velázquez, Stephen Gavalas, Wanli Wu, Kevin Chen, Anilkumar Nair, F. Bennett, Yuhua Huang, P. Pinto, Yueheng Jiang, O. Selyutin, B. Vibulbhan, Qingbei Zeng, C. Lesburg, J. Duca, Hsueh‐Cheng Huang, S. Agrawal, Chuan-kui Jiang, E. Ferrari, Cheng Li, J. Kozlowski, S. Rosenblum, N. Shih, F. Njoroge (2013)
Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.Bioorganic & medicinal chemistry, 21 7
G. Keserű, T. Soós, C. Kappe (2014)
Anthropogenic reaction parameters--the missing link between chemical intuition and the available chemical space.Chemical Society reviews, 43 15
T. Schwalbe, Volker Autze, G. Wille (2002)
Chemical synthesis in microreactorsChimia, 56
L. Hroch, L. Aitken, Ondřej Benek, M. Doležal, K. Kuča, F. Gunn-Moore, K. Musílek (2015)
Benzothiazoles - scaffold of interest for CNS targeted drugs.Current medicinal chemistry, 22 6
A. Aboraia, S. Yee, M. Gomaa, N. Shah, A. Robotham, Bart Makowski, D. Prosser, A. Brancale, Glenville Jones, C. Simons (2010)
Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.Bioorganic & medicinal chemistry, 18 14
V. Telvekar, Harshal Bachhav, V. Bairwa (2012)
A Novel System for the Synthesis of 2-Aminobenzthiazoles using Sodium DichloroiodateSynlett, 23
In medicinal chemistry, the development of synthetic procedures for the access of new heterocyclic systems as potential scaffolds is elementary. Herein, we report our results on the formation of small drug-like heterocycles, utilizing flow chemistry. This approach enables the extension of the reaction parameter window, including high-pressure/high-temperature or hazardous chemistry. In our work, various novel condensed tricyclic benzothiazoles fused with furo- and thieno-rings were synthesized applying a multistep continuous-flow protocol. The process includes two ring closure steps and a nitro group reduction step. Batch and telescoped continuous-flow syntheses were also designed and performed.[graphic not available: see fulltext]
Journal of Flow Chemistry – Springer Journals
Published: Apr 30, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.