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Multidrug Therapy for HIV Infection: Dynamics of Immune System

Multidrug Therapy for HIV Infection: Dynamics of Immune System A mathematical model of the dynamics of the immune system is considered to illustrate the effect of its response to HIV infection, i.e. on viral growth and on T-cell dynamics. The specific immune response is measured by the levels of cytotoxic lymphocytes in a human body. The existence and stability analyses are performed for infected steady state and uninfected steady state. In order to keep infection under control, roles of drug therapies are analyzed in the presence of efficient immune response. Numerical simulations are computed and exhibited to illustrate the support of the immune system to drug therapies, so as to ensure the decay of infection and to maintain the level of healthy cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biotheoretica Springer Journals

Multidrug Therapy for HIV Infection: Dynamics of Immune System

Acta Biotheoretica , Volume 67 (2) – Dec 4, 2018

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References (44)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Nature B.V.
Subject
Philosophy; Philosophy of Biology; Evolutionary Biology
ISSN
0001-5342
eISSN
1572-8358
DOI
10.1007/s10441-018-9340-0
Publisher site
See Article on Publisher Site

Abstract

A mathematical model of the dynamics of the immune system is considered to illustrate the effect of its response to HIV infection, i.e. on viral growth and on T-cell dynamics. The specific immune response is measured by the levels of cytotoxic lymphocytes in a human body. The existence and stability analyses are performed for infected steady state and uninfected steady state. In order to keep infection under control, roles of drug therapies are analyzed in the presence of efficient immune response. Numerical simulations are computed and exhibited to illustrate the support of the immune system to drug therapies, so as to ensure the decay of infection and to maintain the level of healthy cells.

Journal

Acta BiotheoreticaSpringer Journals

Published: Dec 4, 2018

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