Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Multi-step continuous flow synthesis of fluconazole

Multi-step continuous flow synthesis of fluconazole Abstract The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system. ᅟ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Multi-step continuous flow synthesis of fluconazole

Download PDF
8 pages

Loading next page...
 
/lp/springer-journals/multi-step-continuous-flow-synthesis-of-fluconazole-jVIpF6Gpal
Publisher
Springer Journals
Copyright
2018 Akadémiai Kiadó
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-018-0019-0
Publisher site
See Article on Publisher Site

Abstract

Abstract The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system. ᅟ

Journal

Journal of Flow Chemistry – Springer Journals

Published: Mar 1, 2019

References

  • 825–840
    Becher R, Wirsel SG
  • 8494–8504
    Abe F, Usui K, Hiraki T
  • //www.who.int/medicines/publications/essentialmedicines/en/Retrieved 27 February 2018
    WHO Model List of Essential Medicines
  • 8593
    Wang Y, Bian C
  • Korwar S, Amir S, Tosso PN, Desai BK, Kong CJ, Fadnis S, Telang NS, Ahmad S, Roper TD, Gupton BF (2017) Eur J Org Chem 6495–6498
    Korwar S, Amir S, Tosso PN, Desai BK, Kong CJ, Fadnis S, Telang NS, Ahmad S, Roper TD, Gupton BF
  • Preparation of fluconazole from epoxy chloropropane through addition reaction, oxidation, and Grignard reaction
    Yang Y, Gong Z, Yang K
  • A Process for preparation of fluconazole
    Palomo Coll
  • 304
    Wu C, Li X, Shi X, Shi Y, Wang M