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Multi-electrochemical signal generation using metalloprotein based on selective surface modification

Multi-electrochemical signal generation using metalloprotein based on selective surface modification Abstract In this research, we demonstrate a simple method to generate a multi-peak in a single electrochemical signal for the application to bioelectronics devices. Myoglobin is used as a source of electrochemical signal, and its property of redox peak is controlled by the introduction of various chemical-linking materials. Based on controlled signals of myoglobin, multisignal having dual peak is achieved by the signal combination of six electrodes, which have different electrochemical signals by the modification of each electrode with different kinds of chemical linkers individually. For the device formation, selective immobilization process was performed by using reductive cleavage of pre-immobilized thiol group. As a result, the proposed concept shows simple and effective formation of a multi-signal in a single electrochemical signal as compared with other methods based on heterolayer and hybrid materials, and it can be directly applied to materialize practical bioelectronic devices such as a bio-logic gate or bio-computing system http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioChip Journal Springer Journals

Multi-electrochemical signal generation using metalloprotein based on selective surface modification

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References (19)

Publisher
Springer Journals
Copyright
2017 The Korean BioChip Society and Springer-Verlag GmbH Germany, part of Springer Nature
ISSN
1976-0280
eISSN
2092-7843
DOI
10.1007/s13206-017-1409-3
Publisher site
See Article on Publisher Site

Abstract

Abstract In this research, we demonstrate a simple method to generate a multi-peak in a single electrochemical signal for the application to bioelectronics devices. Myoglobin is used as a source of electrochemical signal, and its property of redox peak is controlled by the introduction of various chemical-linking materials. Based on controlled signals of myoglobin, multisignal having dual peak is achieved by the signal combination of six electrodes, which have different electrochemical signals by the modification of each electrode with different kinds of chemical linkers individually. For the device formation, selective immobilization process was performed by using reductive cleavage of pre-immobilized thiol group. As a result, the proposed concept shows simple and effective formation of a multi-signal in a single electrochemical signal as compared with other methods based on heterolayer and hybrid materials, and it can be directly applied to materialize practical bioelectronic devices such as a bio-logic gate or bio-computing system

Journal

BioChip Journal – Springer Journals

Published: Dec 1, 2017

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