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Montelukast for seasonal allergic rhinitis

Montelukast for seasonal allergic rhinitis James N. Baraniuk, MD Cysteinyl Leukotrienes and Allergic Responses Church MK, Griffiths TJ, Jeffery S, et al.: Are cysteinyl Editor’s comments leukotrienes involved in allergic responses in human skin? Clin Exp Allergy 2002, 32:1013–1019. These findings differ from nasal mucosal provocations in which PGD2, but not histamine, was increased in the late- Rating: Of importance. phase response. The absence of leukotriene production in the skin requires confirmation, but suggests that leuko- Aims: To determine the involvement of cysteinyl leuko- triene-active drugs have no role in cutaneous allergic reac- trienes in allergic responses to human skin. tions. The association of leukotriene-generating enzymes with myeloid series cells was confirmed. Of potential signifi- Methods: Thirteen atopic subjects were given intradermal cance was the increase in predominantly eosinophil COX2, injections of grass pollen or Dermatophagoides pteronyssinus. but not COX1, expression. The absence of mediators in the During the immediate phase, approximately 84 pmol of his- cutaneous late-phase response microdialysis fluids com- tamine, 0.3 pmol of prostaglandin (PG)D2, but no leuko- pared with nasal provocation and lavage studies could be triene (LT)C4/LTD4/LTE4 were recovered by microdialysis. due to lower synthesis rates in the skin; more efficient degra- These mediators were not detected at any http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Montelukast for seasonal allergic rhinitis

Baraniuk, James
Current Allergy and Asthma Reports , Volume 3 (3) – May 27, 2003
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Publisher
Springer Journals
Copyright
Copyright © 2003 by Current Science Inc.
Subject
Medicine & Public Health; Allergology; Pneumology/Respiratory System; Otorhinolaryngology; Infectious Diseases
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-003-0037-2
Publisher site
See Article on Publisher Site

Abstract

James N. Baraniuk, MD Cysteinyl Leukotrienes and Allergic Responses Church MK, Griffiths TJ, Jeffery S, et al.: Are cysteinyl Editor’s comments leukotrienes involved in allergic responses in human skin? Clin Exp Allergy 2002, 32:1013–1019. These findings differ from nasal mucosal provocations in which PGD2, but not histamine, was increased in the late- Rating: Of importance. phase response. The absence of leukotriene production in the skin requires confirmation, but suggests that leuko- Aims: To determine the involvement of cysteinyl leuko- triene-active drugs have no role in cutaneous allergic reac- trienes in allergic responses to human skin. tions. The association of leukotriene-generating enzymes with myeloid series cells was confirmed. Of potential signifi- Methods: Thirteen atopic subjects were given intradermal cance was the increase in predominantly eosinophil COX2, injections of grass pollen or Dermatophagoides pteronyssinus. but not COX1, expression. The absence of mediators in the During the immediate phase, approximately 84 pmol of his- cutaneous late-phase response microdialysis fluids com- tamine, 0.3 pmol of prostaglandin (PG)D2, but no leuko- pared with nasal provocation and lavage studies could be triene (LT)C4/LTD4/LTE4 were recovered by microdialysis. due to lower synthesis rates in the skin; more efficient degra- These mediators were not detected at any

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: May 27, 2003

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