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Molecular Oncology of Gall Bladder Cancer

Molecular Oncology of Gall Bladder Cancer Gall bladder carcinoma (GBC) is a worldwide problem, with a higher incidence in areas of the world where cholelithiasis is common. As GBC is usually diagnosed in an advanced stage, the mortality is high. An understanding of the molecular pathways of carcinogenesis and the mutations involved in the development and progression of GBC could be useful in early diagnosis. Understanding molecular markers of prognosis as well as predictors of outcome could also potentially benefit patients undergoing treatment. New therapies targeting major molecular pathways and immunotherapy are exciting novel therapeutic options. This review focuses on the current understanding of the molecular oncology of GBC. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Indian Journal of Surgical Oncology" Springer Journals

Molecular Oncology of Gall Bladder Cancer

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Publisher
Springer Journals
Copyright
Copyright © Indian Association of Surgical Oncology 2019
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery
ISSN
0975-7651
eISSN
0976-6952
DOI
10.1007/s13193-019-01008-2
Publisher site
See Article on Publisher Site

Abstract

Gall bladder carcinoma (GBC) is a worldwide problem, with a higher incidence in areas of the world where cholelithiasis is common. As GBC is usually diagnosed in an advanced stage, the mortality is high. An understanding of the molecular pathways of carcinogenesis and the mutations involved in the development and progression of GBC could be useful in early diagnosis. Understanding molecular markers of prognosis as well as predictors of outcome could also potentially benefit patients undergoing treatment. New therapies targeting major molecular pathways and immunotherapy are exciting novel therapeutic options. This review focuses on the current understanding of the molecular oncology of GBC.

Journal

"Indian Journal of Surgical Oncology"Springer Journals

Published: Nov 16, 2019

References