Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Molecular Modeling of the Amino-Terminal Domain of the mGluR1 Glutamate Metabotropic Receptor by the Threading Method

Molecular Modeling of the Amino-Terminal Domain of the mGluR1 Glutamate Metabotropic Receptor by... Doklady Chemistry, Vol. 383, Nos. 4–6, 2002, pp. 97–101. Translated from Doklady Akademii Nauk, Vol. 383, No. 5, 2002, pp. 643–647. Original Russian Text Copyright © 2002 by Belenikin, Baskin, Palyulin, Zefirov. CHEMISTRY Molecular Modeling of the Amino-Terminal Domain of the mGluR1 Glutamate Metabotropic Receptor by the Threading Method M. S. Belenikin, I. I. Baskin, V. A. Palyulin, and Academician N. S. Zefirov Received December 11, 2001 The glutamatergic system plays a key role in the ered one is that it is often possible to model rather reli- functioning of the human central nervous system; ably the spatial structures of proteins even in the therefore, knowledge of its structure at the molecular absence of any homology of the primary sequence to level is important not only for the understanding of its the template protein. operation but also for the target-directed design of new The purpose of this work is to construct the spatial drugs, in particular, new neuroprotective drugs based models for the open and closed forms of the amino acid on selective agonists and antagonists of glutamate domain of the mGluR1 receptor by the threading receptors. method and to estimate the potential of this method for Two main http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Chemistry Springer Journals

Molecular Modeling of the Amino-Terminal Domain of the mGluR1 Glutamate Metabotropic Receptor by the Threading Method

Belenikin, M.; Baskin, I.; Palyulin, V.; Zefirov, N.
Doklady Chemistry , Volume 383 (6) – Oct 10, 2004
Download PDF
5 pages

Loading next page...
 
/lp/springer-journals/molecular-modeling-of-the-amino-terminal-domain-of-the-mglur1-oucvacCP1L

References (7)

Publisher
Springer Journals
Copyright
Copyright © 2002 by MAIK “Nauka/Interperiodica”
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
0012-5008
eISSN
1608-3113
DOI
10.1023/A:1015400221642
Publisher site
See Article on Publisher Site

Abstract

Doklady Chemistry, Vol. 383, Nos. 4–6, 2002, pp. 97–101. Translated from Doklady Akademii Nauk, Vol. 383, No. 5, 2002, pp. 643–647. Original Russian Text Copyright © 2002 by Belenikin, Baskin, Palyulin, Zefirov. CHEMISTRY Molecular Modeling of the Amino-Terminal Domain of the mGluR1 Glutamate Metabotropic Receptor by the Threading Method M. S. Belenikin, I. I. Baskin, V. A. Palyulin, and Academician N. S. Zefirov Received December 11, 2001 The glutamatergic system plays a key role in the ered one is that it is often possible to model rather reli- functioning of the human central nervous system; ably the spatial structures of proteins even in the therefore, knowledge of its structure at the molecular absence of any homology of the primary sequence to level is important not only for the understanding of its the template protein. operation but also for the target-directed design of new The purpose of this work is to construct the spatial drugs, in particular, new neuroprotective drugs based models for the open and closed forms of the amino acid on selective agonists and antagonists of glutamate domain of the mGluR1 receptor by the threading receptors. method and to estimate the potential of this method for Two main

Journal

Doklady Chemistry – Springer Journals

Published: Oct 10, 2004

There are no references for this article.