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S. Bliss, Y. Zhang, E. Denkers, Ali Bafghi (1999)
Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12.Journal of immunology, 163 4
P. Barnes, M. Karin (1997)
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.The New England journal of medicine, 336 15
J. Lekstrom-Himes, K. Xanthopoulos (1999)
CCAAT/Enhancer Binding Protein ɛ Is Critical for Effective Neutrophil-Mediated Response to Inflammatory ChallengeBlood, 93
A. Hamasaki, F. Sendo, Kei-ichi Nakayama, N. Ishida, I. Negishi, Kei-ichi Nakayama, S. Hatakeyama (1998)
Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 GeneThe Journal of Experimental Medicine, 188
D. Ballard, E. Dixon, N. Peffer, H. Bogerd, S. Doerre, B. Stein, W. Greene (1992)
The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression.Proceedings of the National Academy of Sciences of the United States of America, 89
K. Tiku, M. Tiku, J. Skosey (1986)
Interleukin 1 production by human polymorphonuclear neutrophils.Journal of immunology, 136 10
Hyung-yong Kim, Y. Rikihisa (2002)
Roles of p38 Mitogen-Activated Protein Kinase, NF-κB, and Protein Kinase C in Proinflammatory Cytokine mRNA Expression by Human Peripheral Blood Leukocytes, Monocytes, and Neutrophils in Response to Anaplasma phagocytophilaInfection and Immunity, 70
L. Romani, A. Mencacci, E. Cenci, R. Spaccapelo, G. Sero, I. Nicoletti, G. Trinchieri, F. Bistoni, P. Puccetti (1997)
Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice.Journal of immunology, 158 11
Lin Chen, F. Sendo (2001)
Cytokine and chemokine mRNA expression in neutrophils from CBA/NSlc mice infected with Plasmodium berghei ANKA that induces experimental cerebral malaria.Parasitology international, 50 2
V. Witko-Sarsat, P. Rieu, B. Descamps-Latscha, P. Lesavre, L. Halbwachs‐Mecarelli (2000)
Neutrophils: Molecules, Functions and Pathophysiological AspectsLaboratory Investigation, 80
A. Lloyd, Joost Oppenheim (1992)
Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response.Immunology today, 13 5
Lin Chen, T. Watanabe, H. Watanabe, F. Sendo (2001)
Neutrophil depletion exacerbates experimental Chagas' disease in BALB / c, but protects C57BL / 6 mice through modulating the Th1 / Th2 dichotomy in different directionsEuropean Journal of Immunology, 31
and Baeuerle, T. Henkel (1994)
Function and activation of NF-kappa B in the immune system.Annual review of immunology, 12
H. Baribault, J. Penner, R. Iozzo, M. Wilson-Heiner (1994)
Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice.Genes & development, 8 24
V. Supajatura, H. Ushio, A. Nakao, K. Okumura, C. Ra, H. Ogawa (2001)
Protective Roles of Mast Cells Against Enterobacterial Infection Are Mediated by Toll-Like Receptor 41The Journal of Immunology, 167
L. Romani, A. Mencacci, E. Cenci, G. Sero, F. Bistoni, P. Puccetti (1997)
An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.Journal of immunology, 158 5
C. Jobin, R. Sartor (2000)
The IκB/NF-κB system: a key determinant of mucosal inflammation and protectionAmerican Journal of Physiology-cell Physiology, 278
(1994)
Function and activation of NFjB in the immune system
P. Domenico, D. Diedrich, D. Straus (1985)
Extracellular polysaccharide production by Klebsiella pneumoniae and its relationship to virulence.Canadian journal of microbiology, 31 5
Y. Bergeron, Anne Deslauriers, N. Ouellet, M. Gauthier, M. Bergeron (1999)
Influence of Cefodizime on Pulmonary Inflammatory Response to Heat-Killed Klebsiella pneumoniae in MiceAntimicrobial Agents and Chemotherapy, 43
Z. Zentay, M. Sharaf, M. Qadir, D. Drafta, D. Davidson (1999)
Mechanism for Dexamethasone Inhibition of Neutrophil Migration upon Exposure to Lipopolysaccharide in Vitro: Role of Neutrophil Interleukin-8 ReleasePediatric Research, 46
M. Cassatella (1999)
Neutrophil-derived proteins: selling cytokines by the pound.Advances in immunology, 73
T. Blackwell, J. Christman (1997)
The role of nuclear factor-kappa B in cytokine gene regulation.American journal of respiratory cell and molecular biology, 17 1
Previous studies have shown that Klebsiella pneumoniae (Kle.p) is an immune function modulator for both neutrophils (polymorphonuclear leukocytes, PMN)s and mononuclear cells. To investigate further the effects of Kle.p on the expression of various cytokines secreted by neutrophils and the subsequent modulation pathways, we measured the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IκB by reverse transcriptase-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), gene micro-array or Western blot before and after Kle.p infection. Neutrophils were shown to express many cytokines and chemokines, including TNF-α, IL-1α, IL-1β, IL-2, nuclear factor (NF)κB, INF-α and INF-β, etc. Kle.p treatment increased neutrophil cytokine production, and this was correlated to a reduction of IκB expression of neutrophils. It was concluded that Kle.p infection can upregulate the immunomodulating function of neutrophils by secreting more cytokines, possibly through the NFκB–IκB pathway.
Comparative Clinical Pathology – Springer Journals
Published: Jun 4, 2004
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