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References (6)
-
F. Carone, S. Nakamura, R. Bacallao, W. Nelson, M. Khokha, Y. Kanwar (1995)
Impaired tubulogenesis of cyst-derived cells from autosomal dominant polycystic kidneys.Kidney international, 47 3
-
N. Cruz, Xuewen Song, Stefan Czerniecki, Ramila Gulieva, A. Churchill, Yong Kim, Kosuke Winston, L. Tran, M. Diaz, Hongxia Fu, L. Finn, Y. Pei, J. Himmelfarb, Benjamin Freedman (2017)
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney diseaseNature materials, 16
-
A. Ong, O. Devuyst, B. Knebelmann, G. Walz (2015)
Autosomal dominant polycystic kidney disease: the changing face of clinical managementThe Lancet, 385
-
L. O’Brien, T. Jou, A. Pollack, Qihang Zhang, S. Hansen, P. Yurchenco, K. Mostov (2001)
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assemblyNature Cell Biology, 3
-
H. Happe, D. Peters (2014)
Translational research in ADPKD: lessons from animal modelsNature Reviews Nephrology, 10
-
S. Rossetti, P. Harris (2007)
Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease.Journal of the American Society of Nephrology : JASN, 18 5
- Publisher
- Springer Journals
- Copyright
- Copyright © 2017 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Materials Science; Materials Science, general; Optical and Electronic Materials; Biomaterials; Nanotechnology; Condensed Matter Physics
- ISSN
- 1476-1122
- eISSN
- 1476-4660
- DOI
- 10.1038/nmat5013
- Publisher site
- See Article on Publisher Site
Abstract
Cysts were generated from organoids in vitro and the removal of adherent cues was shown to play a key role in polycystic kidney disease progression. These cysts resembled those of diseased tissue phenotypically and were capable of remodelling their microenvironment.
Journal
Nature Materials – Springer Journals
Published: Oct 25, 2017