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Modeling Heterogeneity in the Assessment of Treatment Effects on Tumor Development While Accounting for Monotone Dropout

Modeling Heterogeneity in the Assessment of Treatment Effects on Tumor Development While... Our research is motivated by a dose-finding trial study in standard chemotherapy in melanoma involving 62 patients, whose tumor size as biomarker expression and toxicity grade were measured at two cycles of treatments. The effects of different dose levels of a treatment on tumor development are the purpose of these studies. In this study, we model the clustered tumor data with dropouts by pattern mixture Tweedie mixed models where unobserved latent risks are characterized by random effects. An optimal estimation of our model has been done using the orthodox best linear unbiased predictors (BLUP) of random effects. The predicted latent risks help us classify patients into high- and low-risk groups by using cluster analysis approach. We illustrated the method with analysis of the clustered tumor development data. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bulletin of the Malaysian Mathematical Sciences Society Springer Journals

Modeling Heterogeneity in the Assessment of Treatment Effects on Tumor Development While Accounting for Monotone Dropout

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Publisher
Springer Journals
Copyright
Copyright © Malaysian Mathematical Sciences Society and Penerbit Universiti Sains Malaysia 2022
ISSN
0126-6705
eISSN
2180-4206
DOI
10.1007/s40840-021-01225-5
Publisher site
See Article on Publisher Site

Abstract

Our research is motivated by a dose-finding trial study in standard chemotherapy in melanoma involving 62 patients, whose tumor size as biomarker expression and toxicity grade were measured at two cycles of treatments. The effects of different dose levels of a treatment on tumor development are the purpose of these studies. In this study, we model the clustered tumor data with dropouts by pattern mixture Tweedie mixed models where unobserved latent risks are characterized by random effects. An optimal estimation of our model has been done using the orthodox best linear unbiased predictors (BLUP) of random effects. The predicted latent risks help us classify patients into high- and low-risk groups by using cluster analysis approach. We illustrated the method with analysis of the clustered tumor development data.

Journal

Bulletin of the Malaysian Mathematical Sciences SocietySpringer Journals

Published: Jan 4, 2022

Keywords: Best linear unbiased predictor; Clustered data; Missing data; Random effects models; Tweedie family; 62F10; 62J12

References