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Mineral, metalloid, and heavy metal status in sheep with clinical coccidiosis

Mineral, metalloid, and heavy metal status in sheep with clinical coccidiosis Eimeria is highly species-specific, and clinical ovine coccidiosis is generally regarded as a disease of intensive animal husbandry. Immune status of the animal, overcrowding, cold wet weather, poor management, and dietary changes may contribute to oocyst shedding, but the role of minerals on parasite persistency and the interaction between minerals and animal responses to the parasite infestation are not clear. For these reasons, the present study was carried out on 20 sheep that were naturally infected by Eimeria spp and 20 healthy sheep to determine and compare serum concentrations of Se, Fe, Cu, Zn, Mo, Co, Mn, Ca, K, Na, P, Mg, Sr, Cr, Ni, Sn, As, Cd, Pb, and Hg. Fecal samples were analyzed by a basic flotation method, and element concentrations in serum samples were determined using inductively coupled plasma mass spectrometry (ICP-MS). The results showed that the serum levels of iron, phosphorus, and strontium in the sheep holding coccidiosis were significantly lower, while those of copper, magnesium, and mercury were significantly higher than those of the healthy sheep. In the affected group, various negative correlations were found between Cr/Mn, Cr/Ca, Cr/P, Hg/Cu, Cd/Se, Pb/Se, and Mg/Na and positive correlations between Sr/Cu, As/Co, As/Hg, As/Sn, Hg/Zn, Hg/Sn, and Ca/K (P < 0.05). These findings may relate to parasite pathogenesis which induces toxemia, villous atrophy, crypt hyperplasia, cellular infiltration, local edema, and hemorrhage in the ileum, cecum, or colon and finally changes serum mineral status. But the increase in serum mercury concentration and its probable role in the pathogenesis of coccidiosis should be considered in future researches. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Mineral, metalloid, and heavy metal status in sheep with clinical coccidiosis

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-014-1886-x
Publisher site
See Article on Publisher Site

Abstract

Eimeria is highly species-specific, and clinical ovine coccidiosis is generally regarded as a disease of intensive animal husbandry. Immune status of the animal, overcrowding, cold wet weather, poor management, and dietary changes may contribute to oocyst shedding, but the role of minerals on parasite persistency and the interaction between minerals and animal responses to the parasite infestation are not clear. For these reasons, the present study was carried out on 20 sheep that were naturally infected by Eimeria spp and 20 healthy sheep to determine and compare serum concentrations of Se, Fe, Cu, Zn, Mo, Co, Mn, Ca, K, Na, P, Mg, Sr, Cr, Ni, Sn, As, Cd, Pb, and Hg. Fecal samples were analyzed by a basic flotation method, and element concentrations in serum samples were determined using inductively coupled plasma mass spectrometry (ICP-MS). The results showed that the serum levels of iron, phosphorus, and strontium in the sheep holding coccidiosis were significantly lower, while those of copper, magnesium, and mercury were significantly higher than those of the healthy sheep. In the affected group, various negative correlations were found between Cr/Mn, Cr/Ca, Cr/P, Hg/Cu, Cd/Se, Pb/Se, and Mg/Na and positive correlations between Sr/Cu, As/Co, As/Hg, As/Sn, Hg/Zn, Hg/Sn, and Ca/K (P < 0.05). These findings may relate to parasite pathogenesis which induces toxemia, villous atrophy, crypt hyperplasia, cellular infiltration, local edema, and hemorrhage in the ileum, cecum, or colon and finally changes serum mineral status. But the increase in serum mercury concentration and its probable role in the pathogenesis of coccidiosis should be considered in future researches.

Journal

Comparative Clinical PathologySpringer Journals

Published: Feb 20, 2014

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