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Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions

Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions Abstract Microreactor-mediated organocatalysed Michael reactions have been developed. By using a soluble proline-derived catalyst, Michael-type reactions, leading to γ-nitroketones, have been optimized in homogeneous and continuous-flow conditions. As proof of principle, an integrated microfluidic system able to perform domino processes useful in the preparation of bicyclo[4.4.0]decanes with six contiguous stereogenic centres has been set up. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions

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Publisher
Springer Journals
Copyright
2013 Akadémiai Kiadó
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1556/jfc-d-13-00003
Publisher site
See Article on Publisher Site

Abstract

Abstract Microreactor-mediated organocatalysed Michael reactions have been developed. By using a soluble proline-derived catalyst, Michael-type reactions, leading to γ-nitroketones, have been optimized in homogeneous and continuous-flow conditions. As proof of principle, an integrated microfluidic system able to perform domino processes useful in the preparation of bicyclo[4.4.0]decanes with six contiguous stereogenic centres has been set up.

Journal

Journal of Flow ChemistrySpringer Journals

Published: Apr 1, 2013

Keywords: chemistry/food science, general; green chemistry; organic chemistry; inorganic chemistry; nanochemistry; industrial chemistry/chemical engineering

References