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Microarchitectural Silk Fibroin/Hyaluronic Acid Scaffold via Slight Biodegradation

Microarchitectural Silk Fibroin/Hyaluronic Acid Scaffold via Slight Biodegradation Silk-based scaffolds with hierarchical structure possess the capacities of promoting cells adhesion, proliferation and neotissue formation, which have been one of the candidates in tissue engineering. However, the ways to construct hierarchical structures in scaffolds are very limited, rather than introducing other nanoscale components. In this study, a hierarchical porous structure was directly established in silk fibroin/hyaluronic acid (SF/HA) scaffold through slight degradation technique. The resulting SF/HA scaffold presented desirable microarchitecture and appropriate porosity attribute to partial hydrolysis of SF molecules. The compression test showed that the SF/HA scaffolds was better than SF scaffolds in terms of compression stress and Young’s modulus. More importantly, the SF/HA scaffolds displayed good cytocompatibility as to supporting cells adhesion and proliferation. This paper provides a new strategy for preparing SF-based scaffolds with hierarchical porous structure in tissue engineering. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fibers and Polymers Springer Journals

Microarchitectural Silk Fibroin/Hyaluronic Acid Scaffold via Slight Biodegradation

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References (17)

Publisher
Springer Journals
Copyright
Copyright © The Korean Fiber Society 2021
ISSN
1229-9197
eISSN
1875-0052
DOI
10.1007/s12221-021-0913-1
Publisher site
See Article on Publisher Site

Abstract

Silk-based scaffolds with hierarchical structure possess the capacities of promoting cells adhesion, proliferation and neotissue formation, which have been one of the candidates in tissue engineering. However, the ways to construct hierarchical structures in scaffolds are very limited, rather than introducing other nanoscale components. In this study, a hierarchical porous structure was directly established in silk fibroin/hyaluronic acid (SF/HA) scaffold through slight degradation technique. The resulting SF/HA scaffold presented desirable microarchitecture and appropriate porosity attribute to partial hydrolysis of SF molecules. The compression test showed that the SF/HA scaffolds was better than SF scaffolds in terms of compression stress and Young’s modulus. More importantly, the SF/HA scaffolds displayed good cytocompatibility as to supporting cells adhesion and proliferation. This paper provides a new strategy for preparing SF-based scaffolds with hierarchical porous structure in tissue engineering.

Journal

Fibers and Polymers – Springer Journals

Published: Apr 26, 2021

Keywords: Silk fibroin; Hyaluronic acid; Microarchitecture; Biomaterials; Degradation

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