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Metal-free catalyzed aerobic oxidation of 2-nitro-4-methylsulfone toluene to 2-nitro-4-methylsulfonylbenzoic acid using a continuous-flow reactor

Metal-free catalyzed aerobic oxidation of 2-nitro-4-methylsulfone toluene to... A metal-free catalyzed oxidation of 2-nitro-4-methylsulfonatotoluene(NMST) to produce 2-nitro-4-methylsulfonatobenzoic acid(NMSBA) under Taylor flow regimes is introduced. N,N′,N″- trihydroxyisocyanuric acid (THICA) as the catalyst and nitric acid as promoter, molecular oxygen as oxidant. The related parameters, such as residence time (τ), reaction temperature (T), and molar flow ratio of oxygen/substrate were investigated systematically. A good yield and selectivity were obtained by taking advantages of continuous flow system. Compared with the traditional batch oxidation process, the new continuous process is more safe and environmentally friendly.Graphical abstract[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Metal-free catalyzed aerobic oxidation of 2-nitro-4-methylsulfone toluene to 2-nitro-4-methylsulfonylbenzoic acid using a continuous-flow reactor

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Publisher
Springer Journals
Copyright
Copyright © Akadémiai Kiadó 2022
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-022-00225-1
Publisher site
See Article on Publisher Site

Abstract

A metal-free catalyzed oxidation of 2-nitro-4-methylsulfonatotoluene(NMST) to produce 2-nitro-4-methylsulfonatobenzoic acid(NMSBA) under Taylor flow regimes is introduced. N,N′,N″- trihydroxyisocyanuric acid (THICA) as the catalyst and nitric acid as promoter, molecular oxygen as oxidant. The related parameters, such as residence time (τ), reaction temperature (T), and molar flow ratio of oxygen/substrate were investigated systematically. A good yield and selectivity were obtained by taking advantages of continuous flow system. Compared with the traditional batch oxidation process, the new continuous process is more safe and environmentally friendly.Graphical abstract[graphic not available: see fulltext]

Journal

Journal of Flow Chemistry – Springer Journals

Published: May 2, 2022

Keywords: Continuous-flow; Metal-free catalyzed oxidation; Molecular oxygen; 2-nitro-4-methylsulfonylbenzoic acid

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