Access the full text.
Sign up today, get DeepDyve free for 14 days.
J.E. Bailey (1991)
Towards a science of metabolic engineeringScience, 252
S. Klamt, J. Stelling, M. Ginkel, D.E. Gilles (2003)
Flux analyzer: exploring structure, pathways, and flux distribution in metabolic networks on interactive flux mapsBioinformatics, 19
W. Leuchtenerger, K. Huthmacher, K. Drauz (2005)
Biotechnological production of amino acids and derivatives: current status and prospectsAppl. Microbiol. Biotechnol., 69
E.A. Savrasova (2007)
Creation of a mini-Mu system devoid of selective markers for gene integration into the chromosome of the bacterium Escherichia coliBiotekhnologiya, 4
G.A. Sprenger (2007)
From scratch to value: engineering Escherichia coli wild type cells to the production of L-phenylalanine and other fine chemicals derived from chorismateAppl. Microbiol. Biotechnol., 75
J. Deutscher, C. Francke, P.W. Postma (2006)
How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteriaMicrobiol. Mol. Biol. Rev., 70
J.L. Barker, J.W. Frost (2001)
Microbial synthesis of p-hydroxybenzoic acid from glucoseBiotechnol. Bioeng., 76
T. Romeo, M. Gong, M.Y. Liu, A.M. Brun-Zinkernagel (1993)
Identification and molecular characterization of csrA, a pleiotropic gene form Escherichia coli that affects glycogen biosynthesis, gluconeogenesis, cell size, and surface propertiesJ. Bacteriol., 175
K.A. Dell, J.W. Frost (1993)
Identification and removal of impediments to biocatalytic synthesis of aromatics from d-glucose: rate-limiting enzymes in the common pathway of aromatic amino acid biosynthesisJ. Am. Chem. Soc., 115
K.D. Brown (1971)
Maintenance and exchange of the aromatic amino acid pool in Escherichia coliJ. Bacteriol., 106
A.A. Gatenby, R. Patnaik, F.S. Sariaslani, W. Suh, T.K. Dyk (2010)
Method of producing an L-tyrosine over-producing bacterial strain
K. Jahreis, L. Bentler, J. Bockmann, S. Hans, A. Meyer, J. Siepelmeyer, J.W. Lengeler (2002)
Adaptation of sucrose metabolism in the V wild-type strain EC3132J. Bacteriol., 184
M. Tatarko, T. Romeo (2001)
Disruption of a global regulatory gene to enhance central carbon flux into phenylalanine biosynthesis in Escherichia coliCurr. Microbiol., 43
Y. Kikuchi, K. Tsujimoto, O. Kurahashi (1997)
Mutational analysis of the feedback sites of phenylalaninesensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coliAppl. Environ. Microbiol., 63
K. Takumi, G. Nonaka (2010)
L-amino acid-producing bacterium and a method for producing an L-amino acid
H. Hori, H. Yoneyama, R. Tobe, T. Ando, E. Isogai, R. Katsumata (2011)
Inducible L-alanine exporter encoded by the novel gene ygaW (alaE) in Escherichia coliAppl. Environ. Microbiol., 77
M.M. Olson, L.J.H. Templeton, S. W, P. Youderian, F.S. Sariaslani, A.A. Gatenby, T.K. Dyk (2007)
Production of L-tyrosine from sucrose or glucose achieved by rapid genetic changes to phenylalanine-producing Escherichia coli strainsAppl. Microbiol. Biotechnol., 74
N. Buschke, R. Schafer, J. Becker, C. Wittmann (2013)
Metabolic engineering of industrial platform microorganisms for biorefinery applications—optimization of substrate spectrum and process robustness by rational and evolutive strategiesBioresour. Technol., 135
A. Haldimann, B.L. Wanner (2001)
Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies of bacteriaJ. Bacteriol., 183
K. Nijakmp, N. Luijk, J.A. Bont, J. Wery (2005)
The solvent-tolerant Pseudomonas putida S12 as host for the production of cinnamic acid from glucoseAppl. Microbiol. Biotechnol., 69
V.A. Livshits, V.G. Doroshenko, S.V. Mashko, V.Z. Akhverdian, Yu.I. Kozlov (2007)
Method of producing amino acids using e. coli transformed with sucrose PTS genes
D. Klein-Marcuschamer, C.N. Santos, H. Yu, G. Stephanopoulos (2009)
Mutagenesis of the bacterial RNA polymerase alpha subunit for improvement of complex phenotypesAppl. Environ. Microbiol., 75
R. Chen, V. Hatzimanikatis, W.M.G.J. Yap, P.W. Postma, J.E. Bailey (1997)
Metabolic consequences of phosphotransferase (pts) mutation in a phenylalanine-producing recombinant Escherichia coliBiotechnol. Prog., 13
K.B. Konstantinov, T.S. Nishio, T. Yoshida (1991)
Physiologically motivated strategies for control of the fed-batch cultivation of recombinant Escherichia coli for phenylalanine productionJ. Bioeng., 71
R. Takeshita, N. Kadotani, K. Abe (2011)
Method for producing a target substance by fermentation
N.J. Grinter (1997)
Developing an L-phenylalanine processChem. Tec., 28
J.H. Park, S.Y. Lee (2008)
Towards systems metabolic engineering of microorganisms for amino acid productionCurr. Opin. Biotechnol., 19
G.N. Stephanopoulos, A.A. Aristidou, J. Nielsen (1998)
Metabolic Engineering: Principles and Methodologies
H. Alper, G. Stephanopoulos (2007)
Global transcription machinery engineering: a new approach for improving cellular phenotypeMetab. Eng., 9
J. Becker, C. Wittmann (2012)
Systems and synthetic metabolic engineering for amino acid production—the heartbeat of industrial strain developmentCurr. Opin. Biotechnol., 23
J. Bockman, H. Heuel, J.W. Lengheler (1992)
Characterization of a chromosomally encoded, non-pts metabolic pathway for sucrose utilization in Escherichia coli EC3132Mol. Gen. Genet., 325
I.G. Fotheringhan, S.A. Bledig, P.P. Taylor (1998)
Characterization of the genes encoding d-amino acid transaminase and glutamate racemase, two D-glutamate biosynthetic enzymes of Bacillus sphaericus ATCC 10207J. Bacteriol., 180
J.L. Baez-Viveros, J. Osuna, G. Hernandez-Chavez, X. Soberon, F. Bolivar, G. Gosset (2004)
Metabolic engineering and protein directed evolution increase the yield of L-phenylalanine synthesized from glucose in Escherichia coliBiotehcnol. Bioeng., 87
V. Doroshenko, L. Airich, M. Vitushkina, A. Kolokolova, V. Livshits, S. Mashko (2007)
YddG from Escherichia coli promotes export of aromatic amino acidsFEMS Microbiol. Letts., 275
J.C. Liao, S.Y. Hou, Y.P. Chao (1996)
Pathway analysis, engineering, and physiological considerations for redirecting central metabolismBiotechnol. Bioeng., 52
O.V. Shpanchenko, E.Yu. Bugaeva, A.V. Golovin, O.A. Dontsova (2010)
Trans-translation: findings and hypothesesMol. Biol. (Moscow), 44
M. Khamduang, K. Packdibamrung, J. Chutmanop, Y. Chisti, P. Srinophakun (2009)
Production of L-phenylalanine from glycerol by a recombinant Escherichia coliJ. Ind. Microbiol. Biotechnol., 36
V.G. Doroshenko, V.A. Livshits (2004)
Structure and mode of transposition of tn2555 carrying sucrose utilization genesFEMS Microbiol. Letts., 233
F. Martinez-Morales, A.C. Borges, A. Martinez, K.T. Shanmugam, L.O. Ingram (1999)
Chromosomal integration of heterologous DNA in Escherichia coli with precise removal of markers and replicons used during constructionJ. Bacteriol., 181
N. Yakandawala, T. Romeo, A.D. Friesen, S. Madhyastha (2008)
Metabolic engineering of Escherichia coli to enhance phenylalanine productionAppl. Microbiol. Biotechnol., 78
A. Kern, E. Tilley, I.S. Hunter, M. Legisa, A. Glieder (2007)
Engineering primary metabolic pathways of industrial micro-organismsJ. Biotechnol., 129
M. Takagi, Y. Nishio, G. Oh, T. Yoshida (1996)
Control of L-phenylalanine production by dual feeding of glucose and L-tyrosineBiotechnol. Bioeng., 52
I.S. Tsyrenzhapova, V.G. Doroshenko, L.G. Airikh, A.S. Mironov, S.V. Mashko (2009)
Gene yddG of Escherichia coli encoding the putative exporter of aromatic amino acids: constitutive transcription and dependence of the expression on the cell growth rateGenetika, 45
B. Hochhut, K. Jahreis, J.W. Lengler, K. Schmid (1997)
CTranscr94, a conjugative transposon found in enterobacteriaJ. Bacteriol., 179
Y.P. Chao, Z.J. Lai, P. Chen, J.T. Chern (1999)
Enhanced conversion rate of L-phenylalanine by coupling reactions of aminotransferases and phosphoenolpyruvate carboxykinase in Escherichia coli K-12Biotechnol. Prog., 15
R. Kramer (1994)
Secretion of amino acids by bacteria: physiology and mechanismFEMS Microbiol. Rev., 13
K. Backman, M.J. O’Connor (1990)
Genetic engineering of metabolic pathways applied to the production of phenylalanineAnn. N. Y. Acad. Sci., 589
D. Koma, H. Yamanaka, K. Moriyoshi, T. Ohmoto, K. Sakai (2012)
Production of aromatic compounds by metabolically engineered Escherichia coli with an expanded shikimate pathwayAppl. Environ. Microbiol., 78
K.B. Konstantinov, T. Yoshida (1990)
On-line monitoring of representative structural variables in fed-batch cultivation of recombinant Escherichia coli for phenylalanine productionJ. Ferm. Bioeng., 70
K. Schmid, R. Ebner, K. Jahreis, J.W. Lengeler, F. Titgemeyer (1991)
A sugar-specific porin, SerY, is involved in sucrose uptake in enteric bacteriaMol. Microbiol., 5
B.L. Wanner (1996)
in Escherichia coli and Salmonella: Cellular and Molecular Biology
J.O. Ahn, H.W. Lee, R. Saha, M.S. Park, J.K. Jung, D.Y. Lee (2008)
Exploring the effects of carbon sources on the metabolic capacity for shikimic acid production in Escherichia coli using in silico metabolic predictionsJ. Microbiol. Biotechnol., 18
J.W. Frost, K.D. Snell, K.M. Frost (1995)
Deblocking the common pathway of aromatic amino acid synthesis
C.N. Santos, W. Xiao, G. Stephanopoulos (2012)
Rational, combinatorial, and genomic approaches for engineering L-tyrosine productionProc. Natl. Acad. Sci. USA, 109
Zh.I. Katashkina, A.Yu. Skorokhodova, D.V. Zimenkov, A.Yu. Gulevich, N.I. Minaeva, V.G. Doroshenko, I.V. Biryukova, S.V. Mashko (2005)
Tuning the expression level of a gene located on a bacterial chromosomeMol. Biol. (Moscow), 39
J. Wang, L. Liu, H. Zhou, J. Li, G. Du, J. Chen (2011)
Comparative study of L-phenylalanine production in the growing and stationary phases during high cell density cultivation of an ausotrophic Escherichia coliBiotechnol. Bioprocess Eng., 16
N.H. Park, P.L. Rogers (1986)
L-phenylalanine production in continuous culture using a hyperproducing mutant of Escherichia coli K-12Chem. Eng. Commun., 45
V.A. Livshits, N.P. Zakataeva, V.V. Aleshin, M.V. Vitushkina (2003)
Identification and characterization of the new gene rhtA in threonine and homoserine efflux in Escherichia coliRes. Microbiol., 154
N. Tsujioto, T. Suzuki, H. Ito (2006)
Method for producing target substance using microorganisms with reduced interactions between MalK and IIAGlc
J. Wang, L.K. Cheng, J. Wang, Q. Liu, T. Shen, N. Chen (2013)
Genetic engineering of Escherichia coli to enhance production of L-tryptophanAppl. Microbiol Biotechnol., 97
T. Nogueira, M. Springer (2000)
Pst-transcriptional control by global regulators of gene expression in bacteriaCurr. Opin. Microbiol., 3
J. Nelms, R.M. Edwards, J. Warwick, I. Fotheringham (1992)
Novel mutations in the pheA gene of Escherichia coli K-12 which result in highly feedback inhibition-resistant variants of chorismate mutase/prephenate dehydrataseAppl. Environ. Microbiol., 58
Y. Toya, N. Kono, A. Kazuharu, M. Tomita (2011)
Metabolic flux analysis and visualizationJ. Proteome Res., 10
T. Koyanagi, T. Katayama, H. Suzuki, H. Kumagai (2004)
Identification of the LIV-I/LS system as the third phenylalanine trasporter in Escherichia coli K-12J. Bacteriol., 186
R. Patnaik, J.C. Liao (1994)
Engineering of Escherichia coli central metabolism for aromatic production with near theoretical yieldAppl. Environ. Microbiol., 60
V.A. Livshits, M.V. Vitushkina, S.V. Mashko, V.G. Doroshenko (2002)
A method for obtaining L-amino acids: an Escherichia coli strain producing the amino acid
T. Romeo, C.A. Vakulskas, P. Babitzke (2013)
Posttranscriptional regulation on a global scale: form and function of Csr/Rsm systemsEnviron. Microbiol., 15
C.J. Chiang, P.T. Chen, Y.P. Chao (2008)
Repliconfree and markerless methods for genomic insertion of DNAs in phage attachment sites and controlled expression of chromosomal genes in Escherichia coliBiotechnol. Bioeng., 101
P. Srinophakum, S. Reakasame, M. Khamduang, K. Packdibamrung, A. Thanapimmetha (2012)
Potential of L-phenylalanine production form raw glycerol of palm biodiesel process by a recombinant Escherichia coliChiang Mai J., 39
M. Ikeda (2006)
Towards bacterial strains overproducing l-tryptophan and other aromatics by metabolic engineeringAppl. Microbiol. Biotechnol., 69
A. Wahl, M.E. Massaoudi, D. Schipper, W. Wiechert, R. Takors (2004)
Serial 13C-based flux analysis of an L-phenylalanine producing E. coli strain using the sensor reactorBiotechnol. Prog, 20
T. Lutke-Evesloh, C.N. Santos, G. Stephanopoulos (2007)
Perspectives of biotechnological production of L-tyrosine and its applicationsAppl. Microbiol. Biotechnol., 77
S. Flores, G. Gosset, N. d. Flores, A.A. Graff, F. Bolivar (2002)
Analysis of carbon metabolism in Escherichia coli strains with an inactive phosphotransferase system by 13C labeling and NMR spectroscopyMetab. Eng., 4
Y.J. Choi, D.E. Tribe (1982)
Continuous production of phenylalanine using an Escherichia coli regulatory mutantBiotechnol. Lett., 4
Z. Sun, Y. Ning, L. Liu, Y. Liu, B. Sun, W. Jiang, C. Yang, S. Yang (2011)
Metabolic engineering of the L-phenylalanine pathway in Escherichia coli for the production of Sor R-andelic acidMicrob. Cell Fact., 10
C.N. Santos, G. Stephanopoulos (2008)
Melanin-based high-throughput screen for L-tyrosine production in Escherichia coliAppl. Environ, Microbiol., 74
D. Koma, H. Yamanaka, K. Moriyoshi, T. Ohmoto, K. Sakai (2012)
A convenient method for multiple insertions of desired genes into target loci on the Escherichia coli chromosomeAppl. Microbiol. Biotechnol., 93
G.P. Silva, M. Mack, J. Contiero (2009)
Glycerol: a promising and abundant carbon source for industrial microbiologyBiotechnol. Adv., 27
V.G. Doroshenko, R.S. Shakulov, S.M. Kazakova, A.D. Kivero, T.A. Yampolskaya, S.V. Mashko (2010)
Construction of an L-phenylalanine-producing tyrosine-prototrophic Escherichia coli strain using tyrA ssrA-like tagged allelesBiotechnol. Lett., 32
L. Eggeling, H. Sahm (2003)
New ubiquitous translocators: amino acid export by corynebacterium glutamicum and Escherichia coliArch. Microbiol., 180
K. Schmid, R. Ebner, J. Altenbuchner, R. Schmitt, J.W. Lengler (1988)
Plasmid-mediated sucrose metabolism in Escherichia coli K12: mapping of the scr genes of pUR400Mol. Microbiol., 2
L.G. Airich, V.G. Doroshenko, I.S. Tsyrenzhapova (2013)
A mutant protein encoded by the yddG gene, and a method for producing aromatic L-amino acids using a bacterium of the genus Escherichia
R. McKenna, D.R. Nielsen (2011)
Styrene biosynthesis form glucose by engineered E. coliMetab. Eng., 13
S.P. Liu, M.E. Xiao, I. Zhang, J. Xu, Z.Y. Ding, Z.H. Gu, G.Y. Shi (2013)
Production of L-phenylalanine from glucose by metabolic engineering of wild type Escherichia coli W3110Process Biochem., 48
K. Koketsu, S. Mitsuhashi, K. Tabata (2013)
Identification of homophenylalanine biosynthetic genes from the cyanobacterium Nostoc punctiforme PCC73102 and application to its microbial production by Escherichia coliAppl. Environ. Microbiol., 78
G. Stephanopoulos (1999)
Metabolic fluxes and metabolic engineeringMetab. Eng., 1
Y. Polen, M. Kramer, J. Bongaerts, M. Wubbolts, V.F. Wendisch (2005)
The global gene expression response of Escherichia coli to L-phenylalanineJ. Biotechnol., 115
V.Z. Akhverdyan, E.A. Savrasova, A.M. Kaplan, A.O. Lobanov, E.Yu. Vavilova, Yu.I. Kozlov (2007)
Development of a mini-Mu system providing efficient integration of genetic material into the chromosome of the bacterium Escherichia coli and its amplificationBiotekhnologiya, 3
P. Wang, J. Yang, A. Ishihama, J. Pittard (1998)
Demonstration that the TyrR protein and RNA polymerase complex formed at the divergent P3 promoter inhibits binding of RNA polymerase to the major promoter, P1, of the aroP gene of Escherichia coliJ. Bacteriol., 180
S. Sabrl, L.K. Nielsen, C.E. Vickers (2013)
Molecular control of sucrose utilization in Escherichia coli W, an efficient sucrose-utilizing strainAppl. Environ. Microbiol., 79
D. Juinaga, E.E. Baidoo, A.M. Reding-Johanson, T.S. Batth, H. Burd, A. Mikhopadhyay, C.J. Petzold, J.D. Keasling (2012)
Modular engineering of Ltyrosine production in Escherichia coliAppl. Environ. Microbiol., 78
J. Bongaerts, M. Kramer, U. Muller, L. Raeven, M. Wubbolts (2001)
Metabolic engineering for microbial production of aromatic amino acids and derived compoundsMetab. Eng., 3
L.G. Airich, I.S. Tsyrenzhapova, O.V. Vorontsova, A.V. Feofanov, V.G. Doroshenko, S.V. Mashko (2010)
Membrane topology analysis of the Escherichia coli aromatic amino acid efflux protein YddGJ. Mol. Microbiol. Biotechnol., 19
P.P. Taylor, N.J. Grinter, S.L. McCarthy, D.P. Pantaleone, J.L. Ton, R.K. Yoshida, I.G. Fotheringham (2001)
D-phenolalanine biosynthesis using Escherichia coli: creation of a new metabolic pathwayApplied Biocatalysis in Specialty Chemicals and Pharmaceuticals, 776
M. Weiner, C. Albermann, K. Gottlieb, G.A. Sprenger, D. Weuster-Botz (2014)
Fed-batch production of L-phenylalanine from glycerol and ammonia with recombinant Escherichia coliBiochem. Eng. J., 83
M.H. f.f.i.x.Jr. Saier, M.R. Yen, K. Noto, D.G. Tamang, C. Elkan (2009)
The transporter classification database: recent advancesNucleic Acid Res., 37
V.G. Doroshenko, I.S. Tsyrenzhapova, A.A. Krylov, E.M. Kiseleva, V.Y. Erishev, S.M. Kazakova, I.V. Biryukova, S.V. Mashko (2010)
Pho regulon promoter-mediated transcription of the key pathway gene aroGFbr improves the performance of an L-phenylalanine-producing Escherichia coli strainAppl. Microbiol. Biotechnol., 8
N.A. Sabnis, H. Ynag, T. Romeo (1995)
Pleiotropic regulation of central carbohydrate metabolism in Escherichia coli via the gene csrAJ. Biol. Chem., 270
D.E. Tribe (1987)
Novel microorganism and method
A. Martínez-Antonio, J. Collado-Vides (2003)
Identifying global regulators in transcriptional regulatory networks in bacteriaCurr. Opin. Microbiol., 6
G. Gosset (2009)
Production of aromatic compounds in bacteriaCurr. Opin. Biotechnol., 20
D.V. Zimenkov (2004)
E. coli chromosome regions preferred for gene insertion when using the integration system based on phage Mu transposonBiotekhnologiya, 6
I.M. Keseler, J. Collado-Vides, A. Santos-Zavaleta, M. Peralta-Gil, S. Hama-Casto, L. Miniz-Racado, C. Bonavides-Martinez, S. Paley, M. Krummenacker, T. Altman, P. Kaipa, A. Spaulding, J. Pacheco, M. Latendresse, C. Fulcher, M. Sarker, A.G. Shearer, A. Mackie, I. Paulsen, R.P. Gunsalus, P.D. Karp (2011)
EcoCyc: a comprehensive database of Escherichia coli biologyNucleic Acid Res., 39
M. Thonhchuang, P. Pongsawasdi, Y. Chisti, K. Packdibamrung (2012)
Design of a recombinant Escherichia coli for producing L-phenylalanine from glycerolJ. Microbiol. Biotechnol., 28
A. Chatzifragkou, S. Papankikolaou (2012)
Effect of impurities in biodiesel-derived waste glycerol on the performance and feasibility of biotechnological processesAppl. Microbiol. Biotechnol., 95
C. Forberg, T. Eliaeson, L. Haggstrom (1988)
Correlation of theoretical and experimental yields of phenylalanine from non-growing cells of a rec Escherichia coli strainJ. Biotechnol., 7
A. Varma, B.W. Boesch, B.O. Palsson (1993)
Biochemical production capabilities of Escherichia coliBiotechnol. Bioeng., 42
In this review, the metabolic engineering approaches including those used by the authors in creating phenylalanine producers based on Escherichia coli were systematized. Optimization of the amino acid biosynthesis was conducted in order to obtain significant quantities of phenylalanine and to ensure the availability of its direct precursors in cell metabolism—erythrose 4-phosphate and phosphoenolpyruvic acid. The possibility of altering global regulation mechanisms was investigated for a full reorientation of the metabolism to phenylalanine synthesis with the use of Csr (carbon storage regulator). The identification of the aromatic amino acids exporter YddG is associated with the use of the phenylalanine producer as a test-system. Novel approaches to phenylalanine producer construction (use of the “leaky” allele tyrA—ssrA, promoters of the phosphate regulon), as well as new methods of obtaining producers of similar amino acid tyrosine, were discussed. Examples of the synthesis of useful aromatic compounds from phenylalanine or its precursor, phenylpyruvic acid, with E. coli as the ecipient for foreign gene expression were examined.
Applied Biochemistry and Microbiology – Springer Journals
Published: Oct 23, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.