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Megakaryocytopoiesis in mice with platelet storage pool deficiency

Megakaryocytopoiesis in mice with platelet storage pool deficiency Megakaryocytopoiesis was evaluated in beige and pallid mice, two strains with platelet storage pool deficiency (SPD). The purpose was to determine if the known deficiency of platelet dense body contents would be associated with evidence for abnormalities of the production or regulation of megakaryocytes. Platelet number and size were normal. Megakaryocyte number and ploidy were normal. Mature megakaryocytes in beige mice were slightly larger than those of control C57BI/6J mice. Megakaryocyte size was normal in pallid mice. No other haemopoietic abnormality was detected in either strain. These findings indicated that there is a mild abnormality of megakaryocyte growth in beige mice. However, this could not be attributed solely to the SPD as it was not present in pallid mice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Megakaryocytopoiesis in mice with platelet storage pool deficiency

Ebbe, S.
Comparative Clinical Pathology , Volume 5 (4) – Jul 21, 2005
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Publisher
Springer Journals
Copyright
Copyright © 1995 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF02044142
Publisher site
See Article on Publisher Site

Abstract

Megakaryocytopoiesis was evaluated in beige and pallid mice, two strains with platelet storage pool deficiency (SPD). The purpose was to determine if the known deficiency of platelet dense body contents would be associated with evidence for abnormalities of the production or regulation of megakaryocytes. Platelet number and size were normal. Megakaryocyte number and ploidy were normal. Mature megakaryocytes in beige mice were slightly larger than those of control C57BI/6J mice. Megakaryocyte size was normal in pallid mice. No other haemopoietic abnormality was detected in either strain. These findings indicated that there is a mild abnormality of megakaryocyte growth in beige mice. However, this could not be attributed solely to the SPD as it was not present in pallid mice.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Jul 21, 2005

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