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Medicinal properties of Clerodendrum glaburum E may leaf extracts: phytochemical constituents, antioxidant, cytotoxicity, and carbohydrate-metabolizing enzyme inhibitory potentials

Medicinal properties of Clerodendrum glaburum E may leaf extracts: phytochemical constituents,... The phytochemical constituents, antioxidant, and cytotoxicity as well as the inhibitory potentials of Clerodendrum glaburum on key carbohydrate metabolizing enzymes were investigated. The plant sample was extracted separately with hexane, EtOAc, MeOH, and water. The phytochemical analysis and antioxidant assays of the extracts were achieved using standard procedures; the antidiabetic capability of the extracts against the actions of α-amylase and α-glucosidase was examined while their cytotox- −1 −1 icity was tested against Vero cells. Highest quantity of phenol (65.97 mg gallic acid g ), flavonoid (47.02 mg quercetin g ), and −1 flavanol (173.74 mg catechin g ) were observed in MeOH extract. Also, MeOH extract had the most potent ability (p <0.05) to scavenge ABTS (0.05 mg/mL), DPPH (0.17 mg/mL), and superoxide anion (0.36 mg/mL) than other extracts and standards. Stronger inhibition (p < 0.05) against metal chelation (26.41 mg/mL) and FRAP (5.92 mg/mL) were observed in water extract compared to other extracts; it also competes favorably with the standard. EtOAc extract displayed best scavenging potentials (p < 0.05) against hydroxyl radical than other extracts. Methanol (0.71 mg/mL) and aqueous (0.19 mg/mL) extracts displayed more potent inhibition against the actions of α-amylase and α-glucosidase respectively compared to acarbose http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Medicinal properties of Clerodendrum glaburum E may leaf extracts: phytochemical constituents, antioxidant, cytotoxicity, and carbohydrate-metabolizing enzyme inhibitory potentials

Ogundajo, Akintayo; Ashafa, Anofi
Comparative Clinical Pathology , Volume OnlineFirst – Sep 24, 2018
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References (61)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag London Ltd., part of Springer Nature
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-018-2825-z
Publisher site
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Abstract

The phytochemical constituents, antioxidant, and cytotoxicity as well as the inhibitory potentials of Clerodendrum glaburum on key carbohydrate metabolizing enzymes were investigated. The plant sample was extracted separately with hexane, EtOAc, MeOH, and water. The phytochemical analysis and antioxidant assays of the extracts were achieved using standard procedures; the antidiabetic capability of the extracts against the actions of α-amylase and α-glucosidase was examined while their cytotox- −1 −1 icity was tested against Vero cells. Highest quantity of phenol (65.97 mg gallic acid g ), flavonoid (47.02 mg quercetin g ), and −1 flavanol (173.74 mg catechin g ) were observed in MeOH extract. Also, MeOH extract had the most potent ability (p <0.05) to scavenge ABTS (0.05 mg/mL), DPPH (0.17 mg/mL), and superoxide anion (0.36 mg/mL) than other extracts and standards. Stronger inhibition (p < 0.05) against metal chelation (26.41 mg/mL) and FRAP (5.92 mg/mL) were observed in water extract compared to other extracts; it also competes favorably with the standard. EtOAc extract displayed best scavenging potentials (p < 0.05) against hydroxyl radical than other extracts. Methanol (0.71 mg/mL) and aqueous (0.19 mg/mL) extracts displayed more potent inhibition against the actions of α-amylase and α-glucosidase respectively compared to acarbose

Journal

Comparative Clinical Pathology – Springer Journals

Published: Sep 24, 2018

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