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Mechanism of Overproduction of Secreted Enzymes in the Mycelial Fungus Penicillium canescens

Mechanism of Overproduction of Secreted Enzymes in the Mycelial Fungus Penicillium canescens The fungus Penicillium canescens strain F178 (VKPM) and its niaD – mutant exhibited an increased capability of synthesizing extracellular enzymes β-galactosidase (50–60 U/ml) and xylanase (100 U/ml). The synthesis was induced by arabinose and its catabolite, arabitol. A deficiency in arabitol dehydrogenase, leading to arabitol accumulation in the cell, was detected in the chain of reactions of arabinose catabolism. The increased synthesis of β-galactosidase and xylanase in P. canescens is accounted for by (1) cellular accumulation of the inducer (arabitol) at low concentrations of arabinose in the medium and (2) prevalence of induction over repression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

Mechanism of Overproduction of Secreted Enzymes in the Mycelial Fungus Penicillium canescens

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References (2)

Publisher
Springer Journals
Copyright
Copyright © 2003 by MAIK “Nauka/Interperiodica”
Subject
Life Sciences; Medical Microbiology; Biochemistry, general; Microbiology
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1023/A:1023519409493
Publisher site
See Article on Publisher Site

Abstract

The fungus Penicillium canescens strain F178 (VKPM) and its niaD – mutant exhibited an increased capability of synthesizing extracellular enzymes β-galactosidase (50–60 U/ml) and xylanase (100 U/ml). The synthesis was induced by arabinose and its catabolite, arabitol. A deficiency in arabitol dehydrogenase, leading to arabitol accumulation in the cell, was detected in the chain of reactions of arabinose catabolism. The increased synthesis of β-galactosidase and xylanase in P. canescens is accounted for by (1) cellular accumulation of the inducer (arabitol) at low concentrations of arabinose in the medium and (2) prevalence of induction over repression.

Journal

Applied Biochemistry and MicrobiologySpringer Journals

Published: Oct 17, 2004

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