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68 1 3 68 Purpose Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid-D-Phe -Tyr -octreotide ( Ga-DOTATOC) is taken up by activated macrophages, which accumulate in active inflammatory lesions. The purpose of this study was to investigate the feasibility of Ga-DOTATOC PET/CT for assessment of vulnerable plaque, by evaluating correlation between aortic uptake of Ga-DOTATOC and cardiovascular risk factors. Methods Fifty patients with neuroendocrine tumors who underwent Ga-DOTATOC PET/CT were retrospectively enrolled. The uptakes in the thoracic aorta were measured by two methods: multi-sample region-of-interest (ROI) method and single volume-of-interest (VOI) method. TBR ,TBR ,TBR , and TBR were defined by maximum and mean max-avg mean-avg max-VOI mean-VOI target-to-background ratio (TBR) from the multi-sample ROI method and the single VOI method, respectively. Results Framingham risk score (FRS) exhibited significant correlations with TBR and TBR , aswellasTBR max-avg mean-avg max-VOI (r =0.3389–0.4593, P < 0.05 for all). TBR and TBR were significantly higher in high FRS group than in low FRS max-avg max-VOI group (1.48 ± 0.21 vs. 1.70 ± 0.17, P <0.001 for TBR and 1.90 ± 0.33 vs. 2.25 ± 0.36, P =0.002 for TBR ). TBR max-avg max-VOI exhibited high correlations between the two measuring methods (r =0.9684, P < 0.001 for
Nuclear Medicine and Molecular Imaging – Springer Journals
Published: May 22, 2018
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