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Lange Clinical and Translational Allergy 2015, 5(Suppl 1):O11 http://www.ctajournal.com/content/5/S1/O11 ORAL PRESENTATION Open Access Magdalena Lange From EAACI Skin Allergy Meeting 2014 Krakow, Poland. 18-20 September 2014 Background Conclusion Mastocytosis is a rare disease of bone marrow-derived Due to a rare incidence of Systemic Mastocytosis in hematopoietic progenitor cells, which is characterized by children, the diagnostic approach in children and adults abnormal growth and excessive accumulation of mast cells presenting MIS should differ. in various tissues. Cutaneous Mastocytosis is a skin limited disease, whereas Systemic Mastocytosis usually involves Published: 11 March 2015 bone marrow, spleen, liver, lymph nodes and gastrointest- inal tract and may present with or without skin involve- ment. The skin is one of the most commonly affected doi:10.1186/2045-7022-5-S1-O11 organboth inchildrenand adults.Mastocytosisinthe Cite this article as: Lange: Mastocytosis in the skin in children and skin (MIS) is defined by a typical exanthema and mono- adults. Clinical and Translational Allergy 2015 5(Suppl 1):O11. morphic mast cell infiltrate. MIS is an initial diagnosis which requires further diagnostic steps leading to the final diagnosis of Cutaneous Mastocytosis or Systemic Mastocytosis. Methods The study group included 140 adult patients and 160 chil- dren presenting MIS. All patients were clinically diagnosed with Systemic Mastocytosis strictly according WHO criteria. Results Cutaneous Mastocytosis was divided into maculopapular type, diffuse type and mastocytoma. Cutaneous Mastocy- tosis was the predominat form of the disease in children. By contrast, in most adult patients Systemic Mastocytosis was recognized. A substantial number of mastocytosis Submit your next manuscript to BioMed Central patients suffered from mediator-related symptoms includ- and take full advantage of: ing pruritus, flushing, hypotension, headache, nausea, abdominal pain, diarrhea and anaphylactic shock among • Convenient online submission others. The present study is focused on the presentation • Thorough peer review of the clinical diversity of Mastocytosis in the skin, demon- • No space constraints or color figure charges strating diagnostic algorithms and comparison of disease • Immediate publication on acceptance features in children and adults diagnosed in the Mastocy- • Inclusion in PubMed, CAS, Scopus and Google Scholar tosis Centre, Medical University of Gdañsk. • Research which is freely available for redistribution Submit your manuscript at Medical University of Gdañsk Department of Dermatology Venereology and www.biomedcentral.com/submit Allergology, Gdañsk, Denmark © 2015 Lange; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Clinical and Translational Allergy – Springer Journals
Published: Mar 11, 2015
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