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Y. Yılmaz, R. Lazova, M. Qumsiyeh, Dennis Cooper, John Pawelek (2005)
Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualization of putative BMT–tumor hybrids by FISHBone Marrow Transplantation, 35
Shi-yun Tan, Yan Fan, He-sheng Luo, Zhi-xiang Shen, Yi Guo, Liang Zhao (2005)
Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer.World journal of gastroenterology, 11 8
A. Chakraborty, J. Pawelek (2007)
&bgr;1,6-branched oligosaccharides regulate melanin content and motility in macrophage–melanoma fusion hybridsMelanoma Research, 17
A. Chakraborty, J. Pawelek, Y. Ikeda, E. Miyoshi, N. Kolesnikova, Y. Funasaka, M. Ichihashi, N. Taniguchi (2001)
Fusion hybrids with macrophage and melanoma cells up-regulate N-acetylglucosaminyltransferase V, beta1-6 branching, and metastasis.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 12 12
Anne Droste, C. Sorg, P. Högger (1999)
Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family.Biochemical and biophysical research communications, 256 1
L. Bingle, Noam Brown, C. Lewis (2002)
The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapiesThe Journal of Pathology, 196
Shau-Hsuan Li, Chien-Feng Li, M. Sung, H. Eng, C. Hsiung, Wen-wei Huang, Ching‐Nan Lin, Shih‐Chen Yu, Hsuan-Ying Huang (2007)
Skp2 is an independent prognosticator of gallbladder carcinoma among p27Kip1-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarrayModern Pathology, 20
L. Busund, M. Killie, K. Bartnes, R. Seljelid (2002)
Spontaneously formed tumorigenic hybrids of Meth A sarcoma and macrophages grow faster and are better vascularized than the parental tumorInternational Journal of Cancer, 100
C. Johansson, S. Youssef, K. Koleckar, C. Holbrook, R. Doyonnas, S. Corbel, L. Steinman, F. Rossi, H. Blau (2008)
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammationNature Cell Biology, 10
Carsten Schlfiter, M. Duchrow, C. Wohlenberg, M. Becker, Gsran Key, H. Flad, J. Gerdes (1993)
The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteinsThe Journal of Cell Biology, 123
S. Oosterling, G. Bij, G. Meijer, C. Tuk, E. Garderen, N. Rooijen, S. Meijer, J. Sijp, R. Beelen, M. Egmond (2005)
Macrophages direct tumour histology and clinical outcome in a colon cancer modelThe Journal of Pathology, 207
Jeremy Chen, Pei-Li Yao, A. Yuan, T. Hong, C. Shun, M. Kuo, Yung‐Chie Lee, Pan‐Chyr Yang (2003)
Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer.Clinical cancer research : an official journal of the American Association for Cancer Research, 9 2
J. Pawelek (2008)
Cancer-cell fusion with migratory bone-marrow-derived cells as an explanation for metastasis: new therapeutic paradigms.Future oncology, 4 4
G. Vassilopoulos, D. Russell (2003)
Cell fusion: an alternative to stem cell plasticity and its therapeutic implications.Current opinion in genetics & development, 13 5
P. Vermeulen, G. Gasparini, Stephen Fox, M. Toi, L. Martin, P. Mcculloch, F. Pezzella, G. Viale, N. Weidner, A. Harris, L. Dirix (1996)
Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation.European journal of cancer, 32A 14
Ashok Chakraborty, R. Lazova, Stella Davies, H. Bäckvall, Fredrik Pontén, Douglas Brash, John Pawelek (2004)
Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipientBone Marrow Transplantation, 34
C. Lackner, Z. Jukić, O. Tsybrovskyy, G. Jatzko, V. Wette, G. Hoefler, M. Klimpfinger, H. Denk, K. Zatloukal (2004)
Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancerVirchows Archiv, 445
L. Busund, M. Killie, K. Bartnes, R. Seljelid (2003)
Spontaneously formed tumorigenic hybrids of Meth A sarcoma cells and macrophages in vivoInternational Journal of Cancer, 106
Tudung Nguyen, E. Schwartz, R. West, R. Warnke, D. Arber, Y. Natkunam (2005)
Expression of CD163 (Hemoglobin Scavenger Receptor) in Normal Tissues, Lymphomas, Carcinomas, and Sarcomas Is Largely Restricted to the Monocyte/Macrophage LineageThe American Journal of Surgical Pathology, 29
Jens Nygren, S. Jovinge, M. Breitbach, Petter Säwén, W. Röll, J. Hescheler, J. Taneera, B. Fleischmann, S. Jacobsen (2004)
Bone marrow–derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiationNature Medicine, 10
H. Dvorak (1986)
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.The New England journal of medicine, 315 26
I. Shabo, O. Stål, H. Olsson, S. Doré, J. Svanvik (2008)
Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survivalInternational Journal of Cancer, 123
A. Mantovani, S. Biswas, M. Galdiero, A. Sica, M. Locati (2013)
Macrophage plasticity and polarization in tissue repair and remodellingThe Journal of Pathology, 229
J. Pawelek, A. Chakraborty (2008)
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasisNature Reviews Cancer, 8
Suash Sharma, M. Sharma, C. Sarkar (2005)
Morphology of angiogenesis in human cancer: a conceptual overview, histoprognostic perspective and significance of neoangiogenesisHistopathology, 46
Jingfang Gao, A. Knutsen, G. Arbman, J. Carstensen, B. Frånlund, Xiao-Feng Sun (2009)
Clinical and biological significance of angiogenesis and lymphangiogenesis in colorectal cancer.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 41 2
Jens Nygren, K. Liuba, M. Breitbach, S. Stott, Lina Thoren, W. Roell, C. Geisen, P. Sasse, D. Kirik, A. Björklund, C. Nerlov, B. Fleischmann, S. Jovinge, S. Jacobsen (2008)
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusionNature Cell Biology, 10
J. Pawelek, A. Chakraborty (2008)
The cancer cell--leukocyte fusion theory of metastasis.Advances in cancer research, 101
J. Pawelek, A. Chakraborty, R. Lazova, Y. Yılmaz, D. Cooper, D. Brash, T. Handerson (2006)
Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion?Contributions to microbiology, 13
S. Sundar, T. Ganesan (2007)
Role of lymphangiogenesis in cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 25 27
C. Murdoch, C. Lewis (2005)
Macrophage migration and gene expression in response to tumor hypoxiaInternational Journal of Cancer, 117
H. Kundel, M. Polansky (2003)
Measurement of observer agreement.Radiology, 228 2
N. Miselis, Zhijin Wu, N. Rooijen, A. Kane (2008)
Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesotheliomaMolecular Cancer Therapeutics, 7
Chunfang Liu, Zhongwei Chen, Zhihong Chen, Tao Zhang, Yuan Lu (2006)
Multiple tumor types may originate from bone marrow-derived cells.Neoplasia, 8 9
TM Leber, F. Balkwill (1998)
Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor (MMPSF).British Journal of Cancer, 78
G. Adell, Hong Zhang, A. Jansson, Xiao-Feng Sun, O. Stål, B. Nordenskjöld (2001)
Decreased tumor cell proliferation as an indicator of the effect of preoperative radiotherapy of rectal cancer.International journal of radiation oncology, biology, physics, 50 3
J. Pawelek (2005)
Tumour-cell fusion as a source of myeloid traits in cancer.The Lancet. Oncology, 6 12
Xiao-Feng Sun, J. Carstensen, O. Stål, Hong Zhang, E. Nilsson, R. Sjödahl, B. Nordenskjöld (2005)
Prognostic significance of p53 expression in relation to DNA ploidy in colorectal adenocarcinomaVirchows Archiv A, 423
J. Houghton, C. Stoicov, S. Nomura, A. Rogers, J. Carlson, Hanchen Li, Xun Cai, J. Fox, J. Goldenring, T. Wang (2004)
Gastric Cancer Originating from Bone Marrow-Derived CellsScience, 306
Anne Powell, E. Anderson, Paige Davies, Alain Silk, C. Pelz, S. Impey, M. Wong (2011)
Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming.Cancer research, 71 4
A. Mantovani, S. Sozzani, M. Locati, P. Allavena, A. Sica (2002)
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.Trends in immunology, 23 11
E. Lin, J. Pollard (2007)
Tumor-associated macrophages press the angiogenic switch in breast cancer.Cancer research, 67 11
M. Augsten, C. Hägglöf, Eleonor Olsson, C. Stolz, P. Tsagozis, Tetyana Levchenko, M. Frederick, Åke Borg, P. Micke, L. Egevad, A. Östman (2009)
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growthProceedings of the National Academy of Sciences, 106
P. Högger, Jens Dreier, Anne Droste, F. Buck, C. Sorg (1998)
Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163).Journal of immunology, 161 4
O. Cecconi, L. Calorini, A. Mannini, G. Mugnai, S. Ruggieri (1997)
Enhancement of lung-colonizing potential of murine tumor cell lines co-cultivated with activated macrophagesClinical & Experimental Metastasis, 15
A. Jansson, Xiao-Feng Sun (1997)
Ki‐67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomasAPMIS, 105
L. Larsson, B. Bjerregaard, L. Wulf-Andersen, J. Talts (2007)
Syncytin and Cancer Cell FusionsThe Scientific World Journal, 7
T. Hagemann, Stephen Robinson, M. Schulz, L. Trümper, F. Balkwill, C. Binder (2004)
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases.Carcinogenesis, 25 8
P. Alexander, S. Eccles, C. Gauci (1976)
THE SIGNIFICANCE OF MACROPHAGES IN HUMAN AND EXPERIMENTAL TUMORS *Annals of the New York Academy of Sciences, 276
Alain Silk, Charles Gast, Paige Davies, Farnaz Fakhari, G. Vanderbeek, M. Mori, M. Wong (2013)
Fusion between Hematopoietic and Epithelial Cells in Adult Human IntestinePLoS ONE, 8
Lidia Larizza, Volker Schirrmacher, Eckhard Pfluger (1984)
Acquisition of high metastatic capacity after in vitro fusion of a nonmetastatic tumor line with a bone marrow-derived macrophageThe Journal of Experimental Medicine, 160
Subhojit Roy, Albert Chu, J. Trojanowski, Paul Zhang (2005)
D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomasActa Neuropathologica, 109
M. Álvarez-Dolado, R. Pardal, J. García-Verdugo, J. Fike, Hyun Lee, K. Pfeffer, C. Lois, S. Morrison, A. Álvarez-Buylla (2003)
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytesNature, 425
Ashok Chakraborty, Josany Sousa, E. Espreafico, John Pawelek (2001)
Human monocyte x mouse melanoma fusion hybrids express human gene.Gene, 275 1
I. Shabo, H. Olsson, Xiao-Feng Sun, J. Svanvik (2009)
Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival timeInternational Journal of Cancer, 125
Ashok Chakraborty, S. Sodi, M. Rachkovsky, Natalia Kolesnikova, James Platt, J. Bolognia, John Pawelek (2000)
A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids.Cancer research, 60 9
M. Rachkovsky, S. Sodi, A. Chakraborty, Y. Avissar, J. Bolognia, J. McNiff, J. Platt, D. Bermudes, J. Pawelek (1998)
Melanoma × macrophage hybrids with enhanced metastatic potentialClinical & Experimental Metastasis, 16
E. Riboldi, C. Porta, S. Morlacchi, A. Viola, A. Mantovani, A. Sica (2013)
Hypoxia-mediated regulation of macrophage functions in pathophysiology.International immunology, 25 2
A. Sica, T. Schioppa, A. Mantovani, P. Allavena (2006)
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy.European journal of cancer, 42 6
The scavenger receptor, CD163, is a macrophage-specific marker. Recent studies have shown that CD163 expression in breast and rectal cancer cells is associated with poor prognosis. This study was conducted to evaluate the relationship between CD163 expression as a macrophage trait in cancer cells, and macrophage infiltration and its clinical significance in colorectal cancer. Immunostaining of CD163 and macrophage infiltration were evaluated in paraffin-embedded specimens, earlier analyzed for CD31, D2-40 and S-phase fraction, from primary tumors and normal colorectal mucosa of 75 patients with colorectal carcinoma. The outcomes were analyzed in relation to clinical-pathological data. CD163 expression was positive in cancer cells in 20 % of colorectal cancer patients and was related to advanced tumor stages (P = 0.008) and unfavorable prognosis (p = 0.001). High macrophage infiltration was related to shorter survival and positive CD163 expression in tumor cells. The prognostic impact of macrophage infiltration was independent of tumor stage and CD163 expression in cancer cells (p = 0.034). The expression of macrophage phenotype in colorectal cancer cells is associated with macrophage density in tumor stroma and lower survival rates. Macrophage infiltration has an independent prognostic impact on mortality in colorectal cancer. In accordance with previous experimental studies, these findings provide new insights into the role of macrophages in colorectal cancer.
Cancer Microenvironment – Springer Journals
Published: Apr 28, 2014
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