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Lymphocytic gastritis in a child with hemophagocytic syndrome

Lymphocytic gastritis in a child with hemophagocytic syndrome Lymphocytic gastritis (LG) is an unusual form of chronic gastritis first described a decade ago in adult patients. The characteristic feature of LG is the surface intraepithelial T-cell lymphocytic infiltration, with relatively few lymphocytes in the lamina propria. Endoscopically, LG often correlates with the features of so-called “varioliform gastritis.” LG has seldom been reported in children, and then usually in association with celiac disease. We describe a case of LG in a 2-year-old child who died of a hepatitis A virus-induced hemophagocytic syndrome (HPS). LG was diagnosed retrospectively at the postmortem examination. The stomach showed diffuse thickening of mucosal folds with small erosions. On microscopic examination prominent intraepithelial infiltration of the gastric mucosa by T-cells was found, but the small bowel showed no villous atrophy, excluding the diagnosis of celiac disease. To the best of our knowledge, this is the first description of a case of LG associated with an infection-related HPS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Diagnostic Paediatric Pathology Springer Journals

Lymphocytic gastritis in a child with hemophagocytic syndrome

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References (11)

Publisher
Springer Journals
Copyright
Copyright © 1998 by Springer-Verlag
Subject
Medicine & Public Health; Pathology
ISSN
1427-4426
eISSN
1509-5762
DOI
10.1007/s100570050005
Publisher site
See Article on Publisher Site

Abstract

Lymphocytic gastritis (LG) is an unusual form of chronic gastritis first described a decade ago in adult patients. The characteristic feature of LG is the surface intraepithelial T-cell lymphocytic infiltration, with relatively few lymphocytes in the lamina propria. Endoscopically, LG often correlates with the features of so-called “varioliform gastritis.” LG has seldom been reported in children, and then usually in association with celiac disease. We describe a case of LG in a 2-year-old child who died of a hepatitis A virus-induced hemophagocytic syndrome (HPS). LG was diagnosed retrospectively at the postmortem examination. The stomach showed diffuse thickening of mucosal folds with small erosions. On microscopic examination prominent intraepithelial infiltration of the gastric mucosa by T-cells was found, but the small bowel showed no villous atrophy, excluding the diagnosis of celiac disease. To the best of our knowledge, this is the first description of a case of LG associated with an infection-related HPS.

Journal

Annals of Diagnostic Paediatric PathologySpringer Journals

Published: Apr 25, 2014

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