Access the full text.
Sign up today, get DeepDyve free for 14 days.
R. Virmani, F. Kolodgie, A. Burke, A. Finn, H. Gold, T. Tulenko, S. Wrenn, J. Narula (2005)
Atherosclerotic Plaque Progression and Vulnerability to Rupture: Angiogenesis as a Source of Intraplaque HemorrhageArteriosclerosis, Thrombosis, and Vascular Biology, 25
T. Sheehan (1965)
For Mechanical EngineersNuclear Technology, 1
D. Kiousis, Stephan Rubinigg, M. Auer, G. Holzapfel (2009)
A methodology to analyze changes in lipid core and calcification onto fibrous cap vulnerability: the human atherosclerotic carotid bifurcation as an illustratory example.Journal of biomechanical engineering, 131 12
Zhiyong Li, S. Howarth, R. Trivedi, J. U-King-im, M. Graves, Andrew Brown, Liqun Wang, J. Gillard (2006)
Stress analysis of carotid plaque rupture based on in vivo high resolution MRI.Journal of biomechanics, 39 14
S. Williamson, Y. Lam, H. Younis, H. Huang, S. Patel, M. Kaazempur-Mofrad, R. Kamm (2003)
On the sensitivity of wall stresses in diseased arteries to variable material properties.Journal of biomechanical engineering, 125 1
Hao Gao, Q. Long, M. Graves, J. Gillard, Zhiyong Li (2009)
Study of reproducibility of human arterial plaque reconstruction and its effects on stress analysis based on multispectral in vivo magnetic resonance imagingJournal of Magnetic Resonance Imaging, 30
H Loree, B Tobias, L Gibson, R. Kamm, D Small, R Lee (1994)
Mechanical properties of model atherosclerotic lesion lipid pools.Arteriosclerosis and thrombosis : a journal of vascular biology, 14 2
N. Takaya, C. Yuan, B. Chu, T. Saam, N. Polissar, G. Jarvik, Carol Isaac, J. McDonough, Cynthia Natiello, R. Small, M. Ferguson, T. Hatsukami (2005)
Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic Plaques: A High-Resolution Magnetic Resonance Imaging StudyCirculation, 111
T. Yamagishi, Makoto Kato, Y. Koiwa, K. Omata, H. Hasegawa, H. Kanai (2009)
Evaluation of plaque stabilization by fluvastatin with carotid intima- medial elasticity measured by a transcutaneous ultrasonic-based tissue characterization system.Journal of atherosclerosis and thrombosis, 16 5
R. Baldewsing, C. Korte, J. Schaar, F. Mastik, A. Steen (2004)
Finite element modeling and intravascular ultrasound elastography of vulnerable plaques: parameter variation.Ultrasonics, 42 1-9
D. Tang, Zhongzhao Teng, G. Canton, T. Hatsukami, Li Dong, Xueying Huang, Chun Yuan (2009)
Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient studyBioMedical Engineering OnLine, 8
H. Yamada, Kopolovic Yuri, N. Sakata (2010)
Correlation between Stress/Strain and the Retention of Lipoproteins and Rupture in Atheromatous Plaque of the Human Carotid Artery: A Finite Element StudyJournal of Biomechanical Science and Engineering, 5
J. Ohayon, G. Finet, A. Gharib, D. Herzka, P. Tracqui, J. Heroux, G. Rioufol, M. Kotys, A. Elagha, R. Pettigrew (2008)
Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture.American journal of physiology. Heart and circulatory physiology, 295 2
E. Falk (2006)
Pathogenesis of atherosclerosis.Journal of the American College of Cardiology, 47 8 Suppl
Plaque ruptures in atherosclerotic carotid arteries cause cerebral strokes. Accumulation of lipoproteins in the deep intimal layer forms a lipid core (LC), whose progression may be enhanced by mechanical conditions on the arterial wall. In this study, we investigated the pressure conditions of a liquid LC through numerical simulations of a sliced segment finite element (FE) model and a three-dimensional (3D) symmetric FE model. A model of an LC filled with nearly incompressible fluid was compared with incompressible and soft neo-Hookean LC models in a static FE analysis. Material constants for a nonlinear hyperelastic model of the arterial wall were identified based on an inflation test using a tube specimen. The results from the FE analysis of a sliced segment model show an LC fluid pressure as low as 1.9 kPa at a blood pressure of 16 kPa. A neo-Hookean LC model with a Young’s modulus of 0.06 kPa produced an almost uniform pressure in the LC within an error of 1.3 %. The 3D model predicted a similar level of LC pressure. Such low fluid pressure in the LC region may enhance the infiltration of lipoproteins and other substances from the lumen and facilitate transport through microvessels from the adventitia to the LC.
Journal of Biorheology – Springer Journals
Published: Aug 1, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.