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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by World Allergy Organization; licensee BioMed Central Ltd.
- Subject
- Medicine & Public Health; Allergology; Immunology
- eISSN
- 1939-4551
- DOI
- 10.1097/WOX.0b013e3181a45f96
- pmid
- 23283015
- Publisher site
- See Article on Publisher Site
Abstract
ORIGINAL ARTICLE Long-Term Effects of Allergen Sensitization and Exposure in Adult Asthma A Prospective Study 1,2 1 1 Stephen J. Fowler, MD, Stephen J. Langley, MD, Nicholas J. Truman, BSc, 1 1 1 Ashley Woodcock, MD, Angela Simpson, MD, and Adnan Custovic, PhD INTRODUCTION Background: We investigated the effects of sensitization and ex- rogressive deterioration in symptoms and an accelerated posure to common domestic allergens on longitudinal changes in Pdecline in lung function are features of the natural history lung function and bronchial hyperresponsiveness. of disease in a proportion of patients with asthma. Identify- Methods: Subjects attended 2 visits that were 4 years apart. Skin ing factors associated with this decline would be an important prick testing was performed and household dust samples were step in the development of strategies aimed at preventing collected for quantification of mite, dog, and cat allergens at base- long-term deterioration, compared with current recommenda- line. Measurements of lung function, exhaled nitric oxide, and tions that principally address short-term symptom control. bronchial hyperresponsiveness were completed at both visits. Among various factors associated with the decline over Results: Dust samples were collected in 165 of the 200 subjects time, the clearest evidence to date has
Journal
World Allergy Organization Journal – Springer Journals
Published: May 15, 2009