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Literature alert

Literature alert Editor James R. Baker, Jr, MD University of Michigan Medical School, 6520 MSRB 1, 1150 W Medical Center, Ann Arbor, MI 48109-0682, USA. E-mail jbakerjr@umich.edu Belostotsky R, Lorberboum-Galski H: Apoptosis-inducing human-origin Fc epsilon-bak/bax chimeric proteins for targeted elimination of mast cells and basophils: a new approach for allergy treatment. J Immunol 2001, 167:4719–4728. Significance: A number of new techniques try to eliminate components of the immediate hyper- sensitivity reaction for therapeutic benefit. One approach is to eliminate IgE molecules with anti- IgE. While the extent of benefit of this technique is still not clear, it shows the value of this approach. Another option is the elimination of the cells that mediate allergic reactions. The limitation of this approach is that most methods that eliminate mast cells and basophils result in the release of medi- ators causing anaphylactoid reactions. New insights into the induction of apoptosis, or pro- grammed cell death, may provide a means for destroying mast cells and basophils without mediator release. The investigators developed a method for specifically inducing apoptosis in mast cells and basophils that does not cause mediator release. While there will be concerns about the elimination of these cells, it appears to be a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Literature alert

Current Allergy and Asthma Reports , Volume 2 (2) – May 25, 2002
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Publisher
Springer Journals
Copyright
Copyright © 2002 by Current Science Inc.
Subject
Medicine & Public Health; Allergology; Pneumology/Respiratory System; Otorhinolaryngology; Infectious Diseases
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-002-0003-4
Publisher site
See Article on Publisher Site

Abstract

Editor James R. Baker, Jr, MD University of Michigan Medical School, 6520 MSRB 1, 1150 W Medical Center, Ann Arbor, MI 48109-0682, USA. E-mail jbakerjr@umich.edu Belostotsky R, Lorberboum-Galski H: Apoptosis-inducing human-origin Fc epsilon-bak/bax chimeric proteins for targeted elimination of mast cells and basophils: a new approach for allergy treatment. J Immunol 2001, 167:4719–4728. Significance: A number of new techniques try to eliminate components of the immediate hyper- sensitivity reaction for therapeutic benefit. One approach is to eliminate IgE molecules with anti- IgE. While the extent of benefit of this technique is still not clear, it shows the value of this approach. Another option is the elimination of the cells that mediate allergic reactions. The limitation of this approach is that most methods that eliminate mast cells and basophils result in the release of medi- ators causing anaphylactoid reactions. New insights into the induction of apoptosis, or pro- grammed cell death, may provide a means for destroying mast cells and basophils without mediator release. The investigators developed a method for specifically inducing apoptosis in mast cells and basophils that does not cause mediator release. While there will be concerns about the elimination of these cells, it appears to be a

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: May 25, 2002

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