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Leukotriene-receptor expression in aspirin-sensitive rhinitis

Leukotriene-receptor expression in aspirin-sensitive rhinitis 202 Rhinitis insights into the specific roles of histamine H-1 and cys- tumult that might result in medical organization pharma- teinyl leukotriene type 1 (CTL-1) LTD4 receptors in allergic ceutical formularies might leave physicians and patients pathophysiology were gained. The imminent switch of lora- wondering about the optimal medication choices to treat tadine to over-the-counter status, potential approval of specific atopic symptoms. Many scientific issues remain to montelukast for treatment of nasal congestion, and the be investigated. Cysteinyl Leukotriene 1 Receptors Shirasaki H, Kanaizumi E, Watanabe K, et al.: Expres- Editor’s comments sion and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. Clin Exp Allergy The authors proposed that LTC4/LTD4/LTE4 might activate 2002, 32:1007–1012. CTL1 on eosinophils and neutrophils in autocrine and paracrine fashion to form positive feedback loops during Rating: Of importance. inflammation. Localization of CTL1 to endothelium sug- gests that CTL1 antagonists and 5-LO inhibitors might Aims: To localize cysteinyl leukotriene 1 receptor expres- alter endothelial adhesion molecule expression and leuko- sion in human nasal mucosa. cyte diapedesis, vascular filling, and plasma extravasation. The absence of CTL1 on exocrine cells conflicts with in Methods: Nasal tissue was examined from six subjects vitro studies showing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Leukotriene-receptor expression in aspirin-sensitive rhinitis

Baraniuk, James
Current Allergy and Asthma Reports , Volume 3 (3) – May 27, 2003
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Publisher
Springer Journals
Copyright
Copyright © 2003 by Current Science Inc.
Subject
Medicine & Public Health; Allergology; Pneumology/Respiratory System; Otorhinolaryngology; Infectious Diseases
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-003-0039-0
Publisher site
See Article on Publisher Site

Abstract

202 Rhinitis insights into the specific roles of histamine H-1 and cys- tumult that might result in medical organization pharma- teinyl leukotriene type 1 (CTL-1) LTD4 receptors in allergic ceutical formularies might leave physicians and patients pathophysiology were gained. The imminent switch of lora- wondering about the optimal medication choices to treat tadine to over-the-counter status, potential approval of specific atopic symptoms. Many scientific issues remain to montelukast for treatment of nasal congestion, and the be investigated. Cysteinyl Leukotriene 1 Receptors Shirasaki H, Kanaizumi E, Watanabe K, et al.: Expres- Editor’s comments sion and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. Clin Exp Allergy The authors proposed that LTC4/LTD4/LTE4 might activate 2002, 32:1007–1012. CTL1 on eosinophils and neutrophils in autocrine and paracrine fashion to form positive feedback loops during Rating: Of importance. inflammation. Localization of CTL1 to endothelium sug- gests that CTL1 antagonists and 5-LO inhibitors might Aims: To localize cysteinyl leukotriene 1 receptor expres- alter endothelial adhesion molecule expression and leuko- sion in human nasal mucosa. cyte diapedesis, vascular filling, and plasma extravasation. The absence of CTL1 on exocrine cells conflicts with in Methods: Nasal tissue was examined from six subjects vitro studies showing

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: May 27, 2003

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