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Lack of evidence for intergenerational inheritance of immune resistance to infections

Lack of evidence for intergenerational inheritance of immune resistance to infections matters arising https://doi.org/10.1038/s41590-021-01102-0 Lack of evidence for intergenerational inheritance of immune resistance to infections 1 1 1 1 1 Eva Kaufmann    , Marija Landekic    , Jeffrey Downey , Julia Chronopoulos , Sara Teimouri Nezhad , 1 1 2 1  ✉  ✉ Kim Tran , Donald C. Vinh , Luis B. Barreiro and Maziar Divangahi    arising from Katzmarski et al. Nature Immunology https://doi.org/10.1038/s41590-021-01052-7 (2021) Epigenetic-mediated memory capacity of the innate immune sys- To investigate whether protection can be masked by an ongo- tem, coined trained immunity, is an evolutionarily conserved trait, ing immune response due to BCG persistence in the parents, we set which enhances host immune responses to subsequent homologous up a second set of experiments in which BCG-vaccinated or non- or heterologous infections . Trained immunity was first discovered vaccinated parents were treated with antimycobacterial antibiotics 2,3 9 in plants and invertebrates that lack an adaptive immune system ; (isoniazid (INH) and rifampicin) for 4 weeks followed by a 2-week however, trained immunity is also a conserved mechanism in washout period. Subsequently, mice were mated, and the offspring higher species like verteberates . Interestingly, vertical transmission were infected with Mtb or IAV (Extended Data Fig. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Immunology Springer Journals

Lack of evidence for intergenerational inheritance of immune resistance to infections

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References (18)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer Nature America, Inc. 2022
ISSN
1529-2908
eISSN
1529-2916
DOI
10.1038/s41590-021-01102-0
Publisher site
See Article on Publisher Site

Abstract

matters arising https://doi.org/10.1038/s41590-021-01102-0 Lack of evidence for intergenerational inheritance of immune resistance to infections 1 1 1 1 1 Eva Kaufmann    , Marija Landekic    , Jeffrey Downey , Julia Chronopoulos , Sara Teimouri Nezhad , 1 1 2 1  ✉  ✉ Kim Tran , Donald C. Vinh , Luis B. Barreiro and Maziar Divangahi    arising from Katzmarski et al. Nature Immunology https://doi.org/10.1038/s41590-021-01052-7 (2021) Epigenetic-mediated memory capacity of the innate immune sys- To investigate whether protection can be masked by an ongo- tem, coined trained immunity, is an evolutionarily conserved trait, ing immune response due to BCG persistence in the parents, we set which enhances host immune responses to subsequent homologous up a second set of experiments in which BCG-vaccinated or non- or heterologous infections . Trained immunity was first discovered vaccinated parents were treated with antimycobacterial antibiotics 2,3 9 in plants and invertebrates that lack an adaptive immune system ; (isoniazid (INH) and rifampicin) for 4 weeks followed by a 2-week however, trained immunity is also a conserved mechanism in washout period. Subsequently, mice were mated, and the offspring higher species like verteberates . Interestingly, vertical transmission were infected with Mtb or IAV (Extended Data Fig.

Journal

Nature Immunology – Springer Journals

Published: Feb 1, 2022

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