Access the full text.
Sign up today, get DeepDyve free for 14 days.
Emily Thompson, H. Sontheimer (2016)
A role for ion channels in perivascular glioma invasionEuropean Biophysics Journal, 45
Tian-Run Liu, Haineng Xu, Menggui Huang, Wen-juan Ma, Deeksha Saxena, R. Lustig, M. Alonso-Basanta, Zhenfeng Zhang, D. O’Rourke, Lin Zhang, Y. Gong, G. Kao, J. Dorsey, Yi Fan (2018)
Circulating Glioma Cells Exhibit Stem Cell-like Properties.Cancer research, 78 23
Y. Iwadate (2016)
Epithelial-mesenchymal transition in glioblastoma progressionOncology Letters, 11
M. Tavazoie, Lieven Veken, V. Silva-Vargas, Marjorie Louissaint, Lucrezia Colonna, Bushra Zaidi, J. García-Verdugo, Fiona Doetsch (2008)
A specialized vascular niche for adult neural stem cells.Cell stem cell, 3 3
U. Verbovšek, C. Noorden, T. Lah (2015)
Complexity of cancer protease biology: Cathepsin K expression and function in cancer progression.Seminars in cancer biology, 35
R. Kozma, Sohail Ahmed, Anthony Best, L. Lim (1995)
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblastsMolecular and Cellular Biology, 15
S. Bao, Qiulian Wu, R. McLendon, Y. Hao, Q. Shi, A. Hjelmeland, M. Dewhirst, D. Bigner, J. Rich (2006)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseNature, 444
A. Torsvik, G. Røsland, A. Svendsen, A. Molven, H. Immervoll, E. McCormack, P. Lønning, M. Primon, E. Sobala, J. Tonn, R. Goldbrunner, C. Schichor, J. Mysliwietz, T. Lah, H. Motaln, S. Knappskog, R. Bjerkvig (2010)
Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track - letter.Cancer research, 70 15
M. Wood, G. Reis, D. Reuss, J. Phillips (2016)
Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at RecurrenceJournal of Neuropathology & Experimental Neurology, 75
M. Pillat, Mona Oliveira, H. Motaln, B. Breznik, T. Glaser, T. Lah, H. Ulrich (2016)
Glioblastoma‐mesenchymal stem cell communication modulates expression patterns of kinin receptors: Possible involvement of bradykinin in information flowCytometry Part A, 89
L. Leeb-Lundberg, D. Kang, Maria Lamb, D. Fathy (2001)
The Human B1 Bradykinin Receptor Exhibits High Ligand-independent, Constitutive ActivityThe Journal of Biological Chemistry, 276
Miloš Vittori, H. Motaln, T. Turnšek (2015)
The Study of Glioma by Xenotransplantation in Zebrafish Early Life StagesJournal of Histochemistry & Cytochemistry, 63
Y. Teng (2015)
Kinin‐B1 and B2 receptors and neural differentiation of pluripotent or multipotent stem cellsCytometry Part A, 87
M. Ceccarelli, F. Barthel, T. Malta, Thaís Sabedot, S. Salama, Bradley Murray, O. Morozova, Yulia Newton, Amie Radenbaugh, S. Pagnotta, Samreen Anjum, Jiguang Wang, G. Manyam, P. Zoppoli, Shiyun Ling, A. Rao, Mia Grifford, A. Cherniack, Hailei Zhang, L. Poisson, C. Carlotti, D. Tirapelli, A. Rao, T. Mikkelsen, C. Lau, W. Yung, R. Rabadán, J. Huse, D. Brat, N. Lehman, J. Barnholtz-Sloan, Siyuan Zheng, K. Hess, G. Rao, M. Meyerson, R. Beroukhim, Lee Cooper, R. Akbani, M. Wrensch, D. Haussler, K. Aldape, P. Laird, D. Gutmann, H. Noushmehr, A. Iavarone, R. Verhaak, H. Arachchi, J. Auman, M. Balasundaram, S. Balu, G. Barnett, Stephen Baylin, Sue Bell, C. Benz, Natalie Bir, K. Black, T. Bodenheimer, L. Boice, M. Bootwalla, Jay Bowen, C. Bristow, Y. Butterfield, Qingrong Chen, L. Chin, Juok Cho, E. Chuah, Sudha Chudamani, Simon Coetzee, M. Cohen, H. Colman, M. Couce, F. D’Angelo, Tanja Davidsen, Amy Davis, John Demchok, K. Devine, Li Ding, R. Duell, J. Elder, J. Eschbacher, Ashley Fehrenbach, M. Ferguson, S. Frazer, Gregory Fuller, J. Fulop, S. Gabriel, L. Garofano, J. Gastier-Foster, N. Gehlenborg, M. Gerken, G. Getz, C. Giannini, W. Gibson, Angela Hadjipanayis, D. Hayes, David Heiman, Beth Hermes, J. Hilty, K. Hoadley, A. Hoyle, Meijuan Huang, S. Jefferys, Corbin Jones, Steven Jones, Z. Ju, A. Kastl, A. Kendler, Jaegil Kim, R. Kucherlapati, Phillip Lai, M. Lawrence, Semin Lee, K. Leraas, T. Lichtenberg, Pei Lin, Yuexin Liu, Jia Liu, J. Ljubimova, Yiling Lu, Yussanne Ma, D. Maglinte, Harshad Mahadeshwar, M. Marra, Mary McGraw, C. McPherson, S. Meng, P. Mieczkowski, C. Miller, G. Mills, Richard Moore, Lisle Mose, A. Mungall, R. Naresh, Theresa Naska, L. Neder, M. Noble, Ardene Noss, B. O'neill, Q. Ostrom, C. Palmer, A. Pantazi, Michael Parfenov, P. Park, J. Parker, C. Perou, C. Pierson, T. Pihl, A. Protopopov, N. Ramirez, W. Rathmell, X. Ren, J. Roach, A. Robertson, G. Saksena, J. Schein, S. Schumacher, J. Seidman, Kelly Senecal, S. Seth, Hui Shen, Yan Shi, J. Shih, K. Shimmel, H. Sicotte, Suzanne Sifri, T. Silva, J. Simons, Rosy Singh, Tara Skelly, A. Sloan, H. Sofia, Matthew Soloway, Xingzhi Song, C. Sougnez, Camila Souza, S. Staugaitis, Huandong Sun, Charlie Sun, Donghui Tan, Jiabin Tang, Yufang Tang, L. Thorne, F. Trevisan, T. Triche, D. Berg, Umadevi Veluvolu, Douglas Voet, Yunhu Wan, Zhining Wang, R. Warnick, J. Weinstein, D. Weisenberger, M. Wilkerson, Felicia Williams, L. Wise, Yingli Wolinsky, Junyuan Wu, A. Xu, Lixing Yang, Liming Yang, Travis Zack, J. Zenklusen, Jianhua Zhang, Wei Zhang, J. Zhang, E. Zmuda (2016)
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse GliomaCell, 164
V. Cuddapah, S. Robel, Stacey Watkins, H. Sontheimer (2014)
A neurocentric perspective on glioma invasionNature Reviews Neuroscience, 15
C. Melzer, Yuanyuan Yang, R. Hass (2016)
Interaction of MSC with tumor cellsCell Communication and Signaling : CCS, 14
LMF Leeb-Lundberg, DS Kang, ME Lamb, DB Fathy (2001)
The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity: roles of residues in the fourth intracellular and third transmembrane domainsJ Biol Chem, 276
V. Patil, Jagriti Pal, K. Somasundaram (2015)
Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencingOncotarget, 6
Dan Zhang, Yijia Wang, Shiwu Zhang (2014)
Asymmetric Cell Division in Polyploid Giant Cancer Cells and Low Eukaryotic CellsBioMed Research International, 2014
L. Barki-Harrington, A. Bookout, Gaofeng Wang, Maria Lamb, L. Leeb-Lundberg, Y. Daaka (2003)
Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells.The Biochemical journal, 371 Pt 2
Haitao Wang, Rikang Wang, T. Thrimawithana, P. Little, Jiangping Xu, Zhong-Ping Feng, Wenhua Zheng (2014)
The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for GlaucomaBioMed Research International, 2014
TK Howcroft, HG Zhang, M Dhodapkar, S Mohla (2011)
Vesicle transfer and cell fusion: emerging concepts of cell-cell communication in the tumor microenvironmentCancer Biol Ther, 12
J. Felsberg, B. Hentschel, K. Kaulich, D. Gramatzki, A. Zacher, B. Malzkorn, M. Kamp, M. Sabel, M. Simon, M. Westphal, G. Schackert, J. Tonn, T. Pietsch, A. Deimling, M. Loeffler, G. Reifenberger, M. Weller (2017)
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent TumorsClinical Cancer Research, 23
Vedrana Montana, H. Sontheimer (2011)
Bradykinin Promotes the Chemotactic Invasion of Primary Brain TumorsThe Journal of Neuroscience, 31
H. Motaln, A. Koren, K. Gruden, Živa Ramšak, C. Schichor, T. Lah (2015)
Heterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistanceOncotarget, 6
S. Baglio, D. Pegtel, N. Baldini (2012)
Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapyFrontiers in Physiology, 3
Vashendriya Hira, Kimberley Ploegmakers, F. Grevers, U. Verbovšek, C. Silvestre-Roig, E. Aronica, W. Tigchelaar, T. Turnšek, Remco Molenaar, C. Noorden (2015)
CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1α, CXCR4, Osteopontin and Cathepsin KJournal of Histochemistry & Cytochemistry, 63
D. Raidoo, S. Sawant, R. Mahabeer, K. Bhoola (1999)
Kinin receptors are expressed in human astrocytic tumour cells.Immunopharmacology, 43 2-3
D. Clapham (1995)
Calcium signalingCell, 80
Erwin Meir, C. Hadjipanayis, A. Norden, H. Shu, P. Wen, J. Olson (2010)
Exciting New Advances in Neuro‐Oncology: The Avenue to a Cure for Malignant GliomaCA: A Cancer Journal for Clinicians, 60
Bethany Hannafon, W. Ding (2013)
Intercellular Communication by Exosome-Derived microRNAs in CancerInternational Journal of Molecular Sciences, 14
T. Dittmar, S. Schwitalla, J. Seidel, S. Haverkampf, G. Reith, Sönke Meyer-Staeckling, B. Brandt, B. Niggemann, K. Zänker (2010)
Characterization of hybrid cells derived from spontaneous fusion events between breast epithelial cells exhibiting stem-like characteristics and breast cancer cellsClinical & Experimental Metastasis, 28
C. Spinelli, L. Montermini, B. Meehan, A. Brisson, Sisareuth Tan, Dongsic Choi, I. Nakano, J. Rak (2018)
Molecular subtypes and differentiation programmes of glioma stem cells as determinants of extracellular vesicle profiles and endothelial cell-stimulating activitiesJournal of Extracellular Vesicles, 7
Hwa-Yong Lee, I. Hong (2017)
Double‐edged sword of mesenchymal stem cells: Cancer‐promoting versus therapeutic potentialCancer Science, 108
A. Klopp, Anshul Gupta, Erika Spaeth, M. Andreeff, F. Marini (2010)
Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth?Stem Cells (Dayton, Ohio), 29
I. Singeç, E. Snyder (2008)
Inflammation as a matchmaker: revisiting cell fusionNature Cell Biology, 10
M. Uchida, Zutang Chen, Yunhui Liu, K. Black (2002)
Overexpression of bradykinin type 2 receptors on glioma cells enhances bradykinin-mediated blood–brain tumor barrier permeability increaseNeurological Research, 24
J. Stewart, L. Gera, D. Chan, P. Bunn, E. York, V. Simkeviciene, B. Helfrich (2002)
Bradykinin-related compounds as new drugs for cancer and inflammation.Canadian journal of physiology and pharmacology, 80 4
M. Overholtzer, A. Mailleux, G. Mouneimne, G. Normand, S. Schnitt, R. King, E. Cibas, J. Brugge (2007)
A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell InvasionCell, 131
A. Zomer, J. Rheenen (2016)
Implications of Extracellular Vesicle Transfer on Cellular Heterogeneity in Cancer: What Are the Potential Clinical Ramifications?Cancer research, 76 8
Katarina Wolf, P. Friedl (2011)
Extracellular matrix determinants of proteolytic and non-proteolytic cell migration.Trends in cell biology, 21 12
J. Mercapide, G. Rappa, A. Lorico (2012)
The intrinsic fusogenicity of glioma cells as a factor of transformation and progression in the tumor microenvironmentInternational Journal of Cancer, 131
J. Teng, Cintia Hora, Rami Kantar, I. Nakano, H. Wakimoto, Tracy Batchelor, E. Chiocca, Christian Badr, B. Tannous (2017)
Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture modelsNeuro-Oncology, 19
F. Marceau (1995)
Kinin B1 receptors: a review.Immunopharmacology, 30 1
J. Björkqvist, Anne Jämsä, T. Renné (2013)
Plasma kallikrein: the bradykinin-producing enzymeThrombosis and Haemostasis, 110
D. Lu, Y. Leung, Ssu-Ming Huang, Kar-lok Wong (2010)
Bradykinin‐induced cell migration and COX‐2 production mediated by the bradykinin B1 receptor in glioma cellsJournal of Cellular Biochemistry, 110
Neža Podergajs, H. Motaln, U. Rajčevič, U. Verbovšek, M. Koršič, Nina Obad, Heidi Espedal, Miloš Vittori, C. Herold‐Mende, H. Miletic, R. Bjerkvig, T. Turnšek (2015)
Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cellsOncotarget, 7
C. Schichor, V. Albrecht, B. Korte, A. Buchner, R. Riesenberg, J. Mysliwietz, Igor Paron, H. Motaln, T. Turnšek, Kathrin Jürchott, J. Selbig, J. Tonn (2012)
Mesenchymal stem cells and glioma cells form a structural as well as a functional syncytium in vitroExperimental Neurology, 234
C. Rodini, Patrícia Silva, A. Assoni, V. Carvalho, O. Okamoto (2018)
Mesenchymal stem cells enhance tumorigenic properties of human glioblastoma through independent cell-cell communication mechanismsOncotarget, 9
J. Durgan, Yun-Yu Tseng, Jens Hamann, M. Domart, L. Collinson, A. Hall, M. Overholtzer, O. Florey (2017)
Mitosis can drive cell cannibalism through entosiseLife, 6
V. Dasari, K. Velpula, K. Kaur, Daniel Fassett, J. Klopfenstein, D. Dinh, M. Gujrati, J. Rao (2010)
Cord Blood Stem Cell-Mediated Induction of Apoptosis in Glioma Downregulates X-Linked Inhibitor of Apoptosis Protein (XIAP)PLoS ONE, 5
C. Trujillo, P. Negraes, T. Schwindt, C. Lameu, C. Carromeu, A. Muotri, J. Pesquero, Débora Cerqueira, M. Pillat, H. Souza, L. Turaça, J. Abreu, H. Ulrich (2012)
Kinin-B2 Receptor Activity Determines the Differentiation Fate of Neural Stem Cells*The Journal of Biological Chemistry, 287
Xianming Zhang, F. Tan, V. Brovkovych, Yongkang Zhang, R. Skidgel (2011)
Cross-talk between Carboxypeptidase M and the Kinin B1 Receptor Mediates a New Mode of G Protein-coupled Receptor Signaling*The Journal of Biological Chemistry, 286
Qianghu Wang, Xin Hu, Baoli Hu, F. Muller, Hoon Kim, M. Squatrito, Tom Millelsen, L. Scarpace, F. Barthel, Yu-Hsi Lin, N. Satani, Emmanuel Martínez-Ledesma, Edward Chang, A. Olar, Guocan Wang, A. deCarvalho, E. Eskilsson, Siyuan Zheng, A. Heimberger, E. Sulman, D. Nam, R. Verhaak (2016)
Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironmentbioRxiv
B. Yan, Jianguo Wang, Li Liu (2015)
Chemotherapy promotes tumour cell hybridization in vivoTumour Biology, 37
J. Côté, V. Bovenzi, M. Savard, Céléna Dubuc, Audrey Fortier, W. Neugebauer, L. Tremblay, W. Müller-Esterl, A. Tsanaclis, M. Lepage, D. Fortin, F. Gobeil (2012)
Induction of Selective Blood-Tumor Barrier Permeability and Macromolecular Transport by a Biostable Kinin B1 Receptor Agonist in a Glioma Rat ModelPLoS ONE, 7
J. Lathia, S. Mack, E. Mulkearns-Hubert, C. Valentim, J. Rich (2015)
Cancer stem cells in glioblastomaGenes & Development, 29
S. Lith, Anna Navis, Krissie Lenting, K. Verrijp, J. Schepens, W. Hendriks, Nil Schubert, H. Venselaar, R. Wevers, A. Rooij, P. Wesseling, Remco Molenaar, C. Noorden, S. Pusch, B. Tops, W. Leenders (2016)
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytomaScientific Reports, 6
Diana Aderetti, Vashendriya Hira, Remco Molenaar, C. Noorden (2018)
The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma.Biochimica et biophysica acta. Reviews on cancer, 1869 2
Adnan Rizvi, John Swain, Paige Davies, A. Bailey, Adria Decker, H. Willenbring, M. Grompe, W. Fleming, M. Wong (2006)
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.Proceedings of the National Academy of Sciences of the United States of America, 103 16
Mohammed Diksin, S. Smith, R. Rahman (2017)
The Molecular and Phenotypic Basis of the Glioma Invasive Perivascular NicheInternational Journal of Molecular Sciences, 18
Daniel Stuckey, K. Shah (2014)
Stem cell-based therapies for cancer treatment: separating hope from hypeNature Reviews Cancer, 14
I. Bryukhovetskiy, V. Shevchenko (2016)
Molecular mechanisms of the effect of TGF-β1 on U87 human glioblastoma cells.Oncology letters, 12 2
A. Nakamizo, F. Marini, T. Amano, Asadullah Khan, M. Studeny, J. Gumin, Julianne Chen, S. Hentschel, G. Vecil, J. Dembinski, M. Andreeff, F. Lang (2005)
Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas.Cancer research, 65 8
E. Lonati, A. Brambilla, C. Milani, M. Masserini, P. Palestini, A. Bulbarelli (2014)
Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer’s disease risk factorFrontiers in Cellular Neuroscience, 8
Vashendriya Hira, U. Verbovšek, B. Breznik, Matic Srdič, Marko Novinec, Hala Kakar, Jill Wormer, Britt Swaan, B. Lenarčič, Luiz Juliano, Shwetal Mehta, C. Noorden, T. Lah (2017)
Cathepsin K cleavage of SDF-1α inhibits its chemotactic activity towards glioblastoma stem-like cells.Biochimica et biophysica acta. Molecular cell research, 1864 3
H. Lee, H. Kim, Ji Kim, Yong Kim, Ki Park, Jae Lee, K. Kim, In Chang, S. Bae, Youngsoo Kim, J. Hong, J. Kehrl, S. Han (2017)
CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptomsScientific Reports, 7
P. Maiuri, Jean-François Rupprecht, S. Wieser, V. Ruprecht, O. Bénichou, Nicolas CARPi, M. Coppey, Simon Beco, N. Gov, C. Heisenberg, C. Crespo, F. Lautenschlaeger, M. Berre, A. Lennon-Duménil, M. Raab, H. Thiam, M. Piel, M. Sixt, R. Voituriez (2015)
Actin Flows Mediate a Universal Coupling between Cell Speed and Cell PersistenceCell, 161
B. Gole, Peter Huszthy, M. Popović, J. Jeruc, Youssef Ardebili, R. Bjerkvig, T. Lah (2012)
The regulation of cysteine cathepsins and cystatins in human gliomasInternational Journal of Cancer, 131
P. Friedl, Katarina Wolf (2003)
Tumour-cell invasion and migration: diversity and escape mechanismsNature Reviews Cancer, 3
L. Molina, C. Matus, A. Astroza, F. Pavicic, Eugenio Tapia, Cesar Toledo, Juan Perez, F. Nualart, C. González, R. Burgos, C. Figueroa, P. Ehrenfeld, M. Poblete (2009)
Stimulation of the bradykinin B1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathwayBreast Cancer Research and Treatment, 118
S. Seifert, H. Sontheimer (2014)
Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migrationThe Journal of Physiology, 592
M. Castro-Manrreza, J. Montesinos (2015)
Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical ApplicationsJournal of Immunology Research, 2015
A. Sottoriva, A. Sottoriva, A. Sottoriva, I. Spiteri, S. Piccirillo, Anestis Touloumis, V. Collins, J. Marioni, C. Curtis, C. Watts, S. Tavaré, S. Tavaré, S. Tavaré (2013)
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamicsProceedings of the National Academy of Sciences, 110
Michael Dalrymple, Debbie Taylor, C. Kettleborough, J. Bryans, R. Solari (2006)
Academia–industry partnerships in drug discoveryExpert Opinion on Drug Discovery, 1
M. Bootman (2012)
Calcium SignalingCold Spring Harbor perspectives in biology, 4 7
T. Steinbichler, J. Dudás, S. Skvortsov, U. Ganswindt, H. Riechelmann, I. Skvortsova (2018)
Therapy resistance mediated by cancer stem cells.Seminars in cancer biology, 53
Roberto Würth, A. Bajetto, J. Harrison, F. Barbieri, T. Florio (2014)
CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironmentFrontiers in Cellular Neuroscience, 8
Young Kim, E. Jeon, M. Kim, J. Lee, J. Kim (2008)
Bradykinin-induced expression of alpha-smooth muscle actin in human mesenchymal stem cells.Cellular signalling, 20 10
Keiko Ishihara, Izumi Hayashi, Shohei Yamashina, Masataka Majima (2001)
A potential role of bradykinin in angiogenesis and growth of S-180 mouse tumors.Japanese journal of pharmacology, 87 4
Daniel Bastida-Ruiz, Kylie Hoesen, Marie Cohen
International Journal of Molecular Sciences the Dark Side of Cell Fusion
J. Behnan, P. Isakson, M. Joel, C. Cilio, I. Langmoen, E. Vik-Mo, Wiaam Badn (2014)
Recruited Brain Tumor‐Derived Mesenchymal Stem Cells Contribute to Brain Tumor ProgressionSTEM CELLS, 32
M. Ifuku, K. Färber, Yuko Okuno, Y. Yamakawa, Taiki Miyamoto, C. Nolte, Vanessa Merrino, S. Kita, T. Iwamoto, I. Komuro, Bing Wang, G. Cheung, Eiichi Ishikawa, H. Ooboshi, M. Bader, K. Wada, H. Kettenmann, M. Noda (2007)
Bradykinin-Induced Microglial Migration Mediated by B1-Bradykinin Receptors Depends on Ca2+ Influx via Reverse-Mode Activity of the Na+/Ca2+ ExchangerThe Journal of Neuroscience, 27
J. Skog, T. Wurdinger, Sjoerd Rijn, D. Meijer, Laura Gainche, M. Sena-Esteves, W. Curry, R. Carter, Anna Krichevsky, X. Breakefield (2008)
Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkersNature cell biology, 10
E. Milkina, A. Ponomarenko, Maria Korneyko, I. Lyakhova, Y. Zayats, S. Zaitsev, P. Mischenko, M. Eliseikina, Y. Khotimchenko, V. Shevchenko, H. Sharma, I. Bryukhovetskiy (2018)
Interaction of hematopoietic CD34+ CD45+ stem cells and cancer cells stimulated by TGF-β1 in a model of glioblastoma in vitroOncology Reports, 40
D. Louis, A. Perry, G. Reifenberger, A. Deimling, D. Figarella-Branger, W. Cavenee, H. Ohgaki, O. Wiestler, P. Kleihues, D. Ellison (2016)
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summaryActa Neuropathologica, 131
P. Ronaldson, T. Davis (2011)
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.Therapeutic delivery, 2 8
(2017)
Kinins in Glioblastoma Microenvironment
T. Dittmar, K. Zänker (2015)
Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid CellsInternational Journal of Molecular Sciences, 16
R. Verhaak, K. Hoadley, E. Purdom, V. Wang, Y. Qi, M. Wilkerson, C. Miller, L. Ding, Todd Golub, J. Mesirov, Gabriele Alexe, M. Lawrence, Michael O’Kelly, P. Tamayo, B. Weir, S. Gabriel, W. Winckler, Supriya Gupta, L. Jakkula, H. Feiler, J. Hodgson, C. James, J. Sarkaria, C. Brennan, A. Kahn, P. Spellman, R. Wilson, T. Speed, J. Gray, M. Meyerson, G. Getz, C. Perou, D. Hayes (2010)
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.Cancer cell, 17 1
F. Ricklefs, M. Mineo, Arun Rooj, I. Nakano, A. Charest, R. Weissleder, X. Breakefield, Chiocca Ea, J. Godlewski, A. Bronisz (2016)
Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity.Cancer research, 76 10
Marieke Mohr, K. Zänker, T. Dittmar (2015)
Cancer (stem) cell differentiation: An inherent or acquired property?Medical hypotheses, 85 6
A. Fattore, R. Luciano, Rossana Saracino, G. Battafarano, C. Rizzo, L. Pascucci, G. Alessandri, A. Pessina, A. Perrotta, A. Fierabracci, M. Muraca (2015)
Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cellsExpert Opinion on Biological Therapy, 15
Yu Shi, Wenchao Zhou, Lin Cheng, Cong Chen, Zhi Huang, X. Fang, Qiulian Wu, Zhi-cheng He, Senlin Xu, J. Lathia, Y. Ping, J. Rich, X. Bian, S. Bao (2016)
Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cellsCell Death and Differentiation, 24
Mona Oliveira, M. Pillat, H. Motaln, H. Ulrich, T. Lah (2018)
Kinin-B1 Receptor Stimulation Promotes Invasion and is Involved in Cell-Cell Interaction of Co-Cultured Glioblastoma and Mesenchymal Stem CellsScientific Reports, 8
Pedro Barcellos-de-Souza, V. Gori, F. Bambi, P. Chiarugi (2013)
Tumor microenvironment: bone marrow-mesenchymal stem cells as key players.Biochimica et biophysica acta, 1836 2
H. Phillips, S. Kharbanda, Ruihuan Chen, W. Forrest, R. Soriano, Thomas Wu, A. Misra, J. Nigro, H. Colman, L. Soroceanu, P. Williams, Z. Modrušan, B. Feuerstein, K. Aldape (2006)
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.Cancer cell, 9 3
R. Wang, Xiaojuan Sun, Christopher Wang, P. Hu, Chia-Yi Chu, Shurong Liu, H. Zhau, L. Chung (2012)
Spontaneous Cancer-Stromal Cell Fusion as a Mechanism of Prostate Cancer Androgen-Independent ProgressionPLoS ONE, 7
E. Whalley, C. Figueroa, L. Gera, K. Bhoola (2012)
Discovery and therapeutic potential of kinin receptor antagonistsExpert Opinion on Drug Discovery, 7
V. Dasari, K. Kaur, K. Velpula, M. Gujrati, Daniel Fassett, J. Klopfenstein, D. Dinh, J. Rao (2010)
Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt PathwayPLoS ONE, 5
(2015)
Cell Fusion. Overviews and Methods. Second Edition.Anticancer research, 35 10
M. Hardee, D. Zagzag (2012)
Mechanisms of glioma-associated neovascularization.The American journal of pathology, 181 4
J. Figueroa, Lynette Phillips, T. Shahar, Anwar Hossain, J. Gumin, Hoon Kim, A. Bean, G. Calin, J. Fueyo, E. Walters, R. Kalluri, R. Verhaak, F. Lang (2017)
Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587.Cancer research, 77 21
B. Breznik, H. Motaln, Miloš Vittori, A. Rotter, T. Turnšek (2017)
Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell linesOncotarget, 8
J. Behnan, Biljana Stangeland, Sam Hosainey, Sam Hosainey, M. Joel, Tk Olsen, Tk Olsen, F. Micci, F. Micci, J. Glover, P. Isakson, J. Brinchmann (2016)
Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotencyOncogene, 36
N. Nicoletti, J. Sénécal, V. Silva, M. Roxo, N. Ferreira, R. Morais, J. Pesquero, M. Campos, R. Couture, F. Morrone (2017)
Primary Role for Kinin B1 and B2 Receptors in Glioma ProliferationMolecular Neurobiology, 54
T. Lah, M. Alonso, C. Noorden (2006)
Antiprotease therapy in cancer: hot or not?Expert Opinion on Biological Therapy, 6
F. Appaix, M. Nissou, B. Sanden, Matthieu Dreyfus, F. Berger, J. Issartel, D. Wion (2014)
Brain mesenchymal stem cells: The other stem cells of the brain?World journal of stem cells, 6 2
K. Bhat, V. Balasubramaniyan, B. Vaillant, R. Ezhilarasan, Karlijn Hummelink, Faith Hollingsworth, K. Wani, L. Heathcock, Johanna James, Lindsey Goodman, S. Conroy, L. Long, Nina Lelic, Suzhen Wang, J. Gumin, D. Raj, Y. Kodama, A. Raghunathan, A. Olar, Kaushal Joshi, C. Pelloski, A. Heimberger, S. Kim, D. Cahill, G. Rao, W. Dunnen, H. Boddeke, H. Phillips, I. Nakano, F. Lang, H. Colman, E. Sulman, K. Aldape (2013)
Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.Cancer cell, 24 3
Lena Edalat, B. Stegen, L. Klumpp, E. Haehl, K. Schilbach, R. Lukowski, M. Kühnle, G. Bernhardt, A. Buschauer, D. Zips, P. Ruth, S. Huber (2016)
BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cellsOncotarget, 7
Xianming Zhang, F. Tan, Yongkang Zhang, R. Skidgel (2008)
Carboxypeptidase M and Kinin B1 Receptors Interact to Facilitate Efficient B1 Signaling from B2 Agonists*Journal of Biological Chemistry, 283
E. Gomes, J. Castro, Bruno Costa, António Salgado (2018)
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas.Biochimie, 155
Remco Molenaar, D. Verbaan, S. Lamba, C. Zanon, J. Jeuken, Sandra Boots-Sprenger, P. Wesseling, T. Hulsebos, D. Troost, A. Tilborg, S. Leenstra, W. Vandertop, A. Bardelli, C. Noorden, F. Bleeker (2014)
The combination of IDH 1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH 1 or MGMT alone
(1995)
Kin in B1 recep tors : a rev iew. Immunopharmacology 30:1–26
F. Papaccio, Francesca Paino, T. Regad, G. Papaccio, V. Desiderio, V. Tirino (2017)
Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer DevelopmentStem Cells Translational Medicine, 6
Remco Molenaar, D. Verbaan, S. Lamba, C. Zanon, J. Jeuken, Sandra Boots-Sprenger, P. Wesseling, T. Hulsebos, D. Troost, A. Tilborg, S. Leenstra, W. Vandertop, A. Bardelli, C. Noorden, F. Bleeker (2014)
The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.Neuro-oncology, 16 9
J. Hood, D. Cheresh (2002)
Role of integrins in cell invasion and migrationNature Reviews Cancer, 2
Remco Molenaar, J. Maciejewski, J. Wilmink, C. Noorden (2018)
Wild-type and mutated IDH1/2 enzymes and therapy responsesOncogene, 37
P. Negraes, C. Trujillo, M. Pillat, Y. Teng, H. Ulrich (2015)
Roles of Kinins in the Nervous SystemCell Transplantation, 24
Y. Teng, Lei Wang, S. Kabataş, H. Ulrich, R. Zafonte (2018)
Cancer Stem Cells or Tumor Survival Cells?Stem Cells and Development, 27
Alasdair Philips, D. Henshaw, Graham Lamburn, M. O'Carroll (2018)
Brain Tumours: Rise in Glioblastoma Multiforme Incidence in England 1995–2015 Suggests an Adverse Environmental or Lifestyle FactorJournal of Environmental and Public Health, 2018
Shuo Shi, Min Zhang, R. Guo, Ying Miao, Biao Li (2016)
Bone Marrow-Derived Mesenchymal Stem Cell-Mediated Dual-Gene Therapy for Glioblastoma.Human gene therapy, 30 1
Anwar Hossain, J. Gumin, F. Gao, J. Figueroa, N. Shinojima, Tatsuya Takezaki, W. Priebe, Diana Villarreal, S. Kang, Celine Joyce, E. Sulman, Qianghu Wang, F. Marini, M. Andreeff, H. Colman, F. Lang (2015)
Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL‐6/gp130/STAT3 PathwaySTEM CELLS, 33
C. Figueroa, C. Matus, F. Pavicic, J. Sarmiento, M. Hidalgo, R. Burgos, C. González, K. Bhoola, P. Ehrenfeld (2015)
Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1Innate Immunity, 21
Anoop Patel, I. Tirosh, John Trombetta, A. Shalek, Shawn Gillespie, H. Wakimoto, D. Cahill, B. Nahed, W. Curry, R. Martuza, D. Louis, O. Rozenblatt-Rosen, M. Suvà, A. Regev, B. Bernstein (2014)
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastomaScience, 344
Seong Kim, C. Jeong, J. Woo, Chung Ryu, Jeong-Hwa Lee, S. Jeun (2015)
In vivo near-infrared imaging for the tracking of systemically delivered mesenchymal stem cells: tropism for brain tumors and biodistributionInternational Journal of Nanomedicine, 11
Yi-Bao Wang, Cheng Peng, Yunhui Liu (2007)
Low dose of bradykinin selectively increases intracellular calcium in glioma cellsJournal of the Neurological Sciences, 258
K. Pfannkuche (2015)
Cell FusionMethods of Molecular Biology, 1313
Qianghu Wang, Baoli Hu, Xin Hu, Hoon Kim, M. Squatrito, L. Scarpace, A. deCarvalho, Sali Lyu, Pengping Li, Yan Li, F. Barthel, H. Cho, Yu-Hsi Lin, N. Satani, Emmanuel Martínez-Ledesma, Siyuan Zheng, Edward Chang, Charles-Etienne Sauvé, A. Olar, Zhengdao Lan, G. Finocchiaro, J. Phillips, M. Berger, Konrad Gabrusiewicz, Guocan Wang, E. Eskilsson, Jian Hu, T. Mikkelsen, R. DePinho, F. Muller, A. Heimberger, E. Sulman, D. Nam, R. Verhaak (2017)
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Cancer cell, 32 1
B. Ogle, M. Cascalho, J. Platt (2005)
Biological implications of cell fusionNature Reviews Molecular Cell Biology, 6
M. Hegi, A. Diserens, T. Gorlia, M. Hamou, N. Tribolet, N. Tribolet, M. Weller, J. Kros, J. Hainfellner, W. Mason, L. Mariani, Jacoline Bromberg, P. Hau, R. Mirimanoff, J. Cairncross, R. Janzer, R. Stupp (2005)
MGMT Gene Silencing and Benefit from Temozolomide in GlioblastomaThe New England Journal of Medicine, 352
H. Motaln, K. Gruden, M. Hren, C. Schichor, M. Primon, A. Rotter, T. Lah (2012)
Human Mesenchymal Stem Cells Exploit the Immune Response Mediating Chemokines to Impact the Phenotype of GlioblastomaCell Transplantation, 21
L. Pavon, T. Sibov, A. Souza, Edgar Cruz, S. Malheiros, F. Cabral, Jean Souza, Pamela Boufleur, Daniela Oliveira, S. Toledo, L. Marti, J. Malheiros, F. Paiva, A. Tannús, S. Oliveira, A. Chudzinski-Tavassi, M. Neto, S. Cavalheiro (2018)
Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivoStem Cell Research & Therapy, 9
Dongye Yi, W. Xiang, Qing Zhang, Yong-cun Cen, Qing Su, Fangcheng Zhang, Yin-ping Lu, Hongyang Zhao, Peng Fu (2018)
Human Glioblastoma-Derived Mesenchymal Stem Cell to Pericytes Transition and Angiogenic Capacity in Glioblastoma MicroenvironmentCellular Physiology and Biochemistry, 46
T. Howcroft, Huang-Ge Zhang, M. Dhodapkar, S. Mohla (2011)
Vesicle transfer and cell fusionCancer Biology & Therapy, 12
Katja Kološa, H. Motaln, C. Herold‐Mende, M. Koršič, T. Lah (2015)
Paracrine Effects of Mesenchymal Stem Cells Induce Senescence and Differentiation of Glioblastoma Stem-Like CellsCell Transplantation, 24
P. Ehrenfeld, C. Matus, F. Pavicic, Cesar Toledo, F. Nualart, C. González, R. Burgos, K. Bhoola, C. Figueroa (2009)
Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease‐9 and myeloperoxidase in human neutrophils: involvement of mitogen‐activated protein kinase familyJournal of Leukocyte Biology, 86
N. Levičar, T. Strojnik, J. Kos, R. Dewey, G. Pilkington, T. Lah (2002)
Lysosomal Enzymes, Cathepsins in Brain Tumour InvasionJournal of Neuro-Oncology, 58
H. Motaln, T. Turnšek (2015)
Cytokines play a key role in communication between mesenchymal stem cells and brain cancer cells.Protein and peptide letters, 22 4
M. SILVA, W. Beraldo, G. Rosenfeld (1949)
Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin.The American journal of physiology, 156 2
Patrícia Costa, P. Sirois, I. Tannock, R. Chammas (2014)
The role of kinin receptors in cancer and therapeutic opportunities.Cancer letters, 345 1
D Bastida-Ruiz, K Hoesen, M Cohen (2016)
The dark side of cell fusionInt J Mol Sci, 17
J. Rao (2003)
Molecular mechanisms of glioma invasiveness: the role of proteasesNature Reviews Cancer, 3
Sheila Singh, I. Clarke, Mizuhiko Terasaki, Victoria Bonn, C. Hawkins, J. Squire, P. Dirks (2003)
Identification of a cancer stem cell in human brain tumors.Cancer research, 63 18
M. Qazi, P. Vora, C. Venugopal, S. Sidhu, J. Moffat, C. Swanton, Sheila Singh (2017)
Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastomaAnnals of Oncology, 28
A. Bajetto, A. Pattarozzi, A. Corsaro, F. Barbieri, A. Daga, A. Bosio, Monica Gatti, V. Pisaturo, R. Sirito, T. Florio (2017)
Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble FactorsFrontiers in Cellular Neuroscience, 11
E. Kashuba, J. Bailey, D. Allsup, L. Cawkwell (2013)
The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkersBiomarkers, 18
Tumour progression involves interactions among various cancer cell clones, including the cancer stem cell subpopulation and exogenous cellular components, termed cancer stromal cells. The latter include a plethora of tumour infiltrating immunocompetent cells, among which are also immuno-modulatory mesenchymal stem cells, which by vigorous migration to growing tumours and susequent transdifferentiation into various types of tumour-residing stromal cells, may either inhibit or support tumour progression. In the light of the scarce therapeutic options existing for the most malignant brain tumour glioblastoma, mesenchymal stem cells may represent a promising novel tool for cell therapy, e.g. drug delivery vectors. Here, we review the increasing number of reports on mutual interactions between mesenchymal stem cells and glioblastoma cells in their microenvironment. We particularly point out two novel aspects: the different responses of cancer cells to their microenvironmental cues, and to the signalling by kinin receptors that complement the immuno-modulating cytokine-signalling networks. Inflammatory glioblastoma microenvironment is characterised by increasing expression of kinin receptors during progressive glioma malignancy, thus making kinin signalling and kinins themselves rather important in this context. In general, their role in tumour microenvironment has not been explored so far. In addition, kinins also regulate blood brain barrier-related drug transfer as well as brain tumour angiogenesis. These studies support the on-going research on kinin antagonists as candidates in the development of anti-invasive agents for adjuvant glioblastoma therapy.
Cancer Microenvironment – Springer Journals
Published: Aug 16, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.