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Japanese Shiba dogs possessing erythrocytes with high Glut-1 activity and high ascorbic acid recycling capacity

Japanese Shiba dogs possessing erythrocytes with high Glut-1 activity and high ascorbic acid... Glut-1 was discovered in erythrocytes of some Japanese Shiba dogs. They have Glut-1 as well as Glut-4 in erythrocytes, while other Shiba dogs and other breeds have only Glut-4. Dog erythrocytes with Glut-1 showed much higher affinity for entry of glucose and oxidized ascorbic acid and greater capacity for ascorbic acid (AA) recycling than those with only Glut-4. Dog is among numerous AA-synthesizing species that normally do not have Glut-1 in erythrocytes. However, this variant of dog is the first example of an AA-synthesizing animal which maintains Glut-1 in erythrocytes throughout life. Shiba dogs can be a new animal model for further understanding the mechanism of regulation and functions of AA in the organism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Japanese Shiba dogs possessing erythrocytes with high Glut-1 activity and high ascorbic acid recycling capacity

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References (35)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Hematology; Oncology; Pathology
eISSN
1618-565X
DOI
10.1007/s00580-010-1148-5
Publisher site
See Article on Publisher Site

Abstract

Glut-1 was discovered in erythrocytes of some Japanese Shiba dogs. They have Glut-1 as well as Glut-4 in erythrocytes, while other Shiba dogs and other breeds have only Glut-4. Dog erythrocytes with Glut-1 showed much higher affinity for entry of glucose and oxidized ascorbic acid and greater capacity for ascorbic acid (AA) recycling than those with only Glut-4. Dog is among numerous AA-synthesizing species that normally do not have Glut-1 in erythrocytes. However, this variant of dog is the first example of an AA-synthesizing animal which maintains Glut-1 in erythrocytes throughout life. Shiba dogs can be a new animal model for further understanding the mechanism of regulation and functions of AA in the organism.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Jan 7, 2011

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