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Ionic Liquid-Based Suzuki Coupling Reaction: From Batch to Continuous Microflow System

Ionic Liquid-Based Suzuki Coupling Reaction: From Batch to Continuous Microflow System Abstract Transformed from heterogeneous to homogeneous state, an ionic liquid (IL)-based Suzuki coupling reaction was successfully implemented in a continuous microflow system. Triethylamine (Et3N) was introduced as the base, and N-methylpyrrolidinone (NMP) was used as the solvent of boronic acid, which brought about the first improvement on the reaction performance. Then, the implementation of this reaction in a continuous microflow system brought about further improvement on the reaction yield and selectivity due to better mixing condition. The combination of IL as the reaction medium and the continuous microflow system as the reactor in this work exhibited great potential for efficient Suzuki coupling reactions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Ionic Liquid-Based Suzuki Coupling Reaction: From Batch to Continuous Microflow System

Journal of Flow Chemistry , Volume 7 (2): 5 – Apr 1, 2017

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References (30)

Publisher
Springer Journals
Copyright
2017 Akadémiai Kiadó
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1556/1846.2017.00002
Publisher site
See Article on Publisher Site

Abstract

Abstract Transformed from heterogeneous to homogeneous state, an ionic liquid (IL)-based Suzuki coupling reaction was successfully implemented in a continuous microflow system. Triethylamine (Et3N) was introduced as the base, and N-methylpyrrolidinone (NMP) was used as the solvent of boronic acid, which brought about the first improvement on the reaction performance. Then, the implementation of this reaction in a continuous microflow system brought about further improvement on the reaction yield and selectivity due to better mixing condition. The combination of IL as the reaction medium and the continuous microflow system as the reactor in this work exhibited great potential for efficient Suzuki coupling reactions.

Journal

Journal of Flow ChemistrySpringer Journals

Published: Apr 1, 2017

Keywords: chemistry/food science, general; green chemistry; organic chemistry; inorganic chemistry; nanochemistry; industrial chemistry/chemical engineering

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