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Investigation of the Gelation of Galactomannan Isolated from the Seeds of Styphnolobium japonicum (Fabaceae)

Investigation of the Gelation of Galactomannan Isolated from the Seeds of Styphnolobium japonicum... —This article is devoted to the study of the structuring process of galactomannan isolated from Japanese Sophora seeds with borate ions. Based on galactomannan isolated from seeds of Japanese Sophora (Styphnolobium japonicum), a basis for a soft dosage form has been developed. The strength properties of the formed gel structures based on the formed galactomannan gels were evaluated depending on the nature of the crosslinking agent introduced into the systems. It is assumed that the network structures of gel systems are formed due to the formation of bridging bonds between the functional groups of galactomannan and boron ions. The rheological properties of the formed jellies have been studied. The study of the galactomannan gelation process showed that the dynamic viscosity depends on pH, the concentration of the crosslinking agent and the concentration of the galactomannan solution. Plasticization of the gel was carried out and it was assumed that the presence of glycerol destroys chemical crosslinking due to the formation of a complex compound with sodium tetraborate. A soft dosage form has been developed with the addition of 10% propylene glycol as a plasticizer and a 0.1% preservative solution. As a result of further studies of the developed soft dosage form, it was revealed that after 6–12 months of storage under natural conditions at a temperature of +20 ± 5°C, the studied gel remained stable. These studies made it possible to use the investigated gel in medicine as a basis for a soft dosage form. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Bioorganic Chemistry Springer Journals

Investigation of the Gelation of Galactomannan Isolated from the Seeds of Styphnolobium japonicum (Fabaceae)

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References (8)

Publisher
Springer Journals
Copyright
Copyright © Pleiades Publishing, Ltd. 2021. ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2021, Vol. 47, No. 7, pp. 1376–1380. © Pleiades Publishing, Ltd., 2021. Russian Text © The Author(s), 2020, published in Khimiya Rastitel’nogo Syr’ya, 2020, No. 1, pp. 33–39.
ISSN
1068-1620
eISSN
1608-330X
DOI
10.1134/s1068162021070074
Publisher site
See Article on Publisher Site

Abstract

—This article is devoted to the study of the structuring process of galactomannan isolated from Japanese Sophora seeds with borate ions. Based on galactomannan isolated from seeds of Japanese Sophora (Styphnolobium japonicum), a basis for a soft dosage form has been developed. The strength properties of the formed gel structures based on the formed galactomannan gels were evaluated depending on the nature of the crosslinking agent introduced into the systems. It is assumed that the network structures of gel systems are formed due to the formation of bridging bonds between the functional groups of galactomannan and boron ions. The rheological properties of the formed jellies have been studied. The study of the galactomannan gelation process showed that the dynamic viscosity depends on pH, the concentration of the crosslinking agent and the concentration of the galactomannan solution. Plasticization of the gel was carried out and it was assumed that the presence of glycerol destroys chemical crosslinking due to the formation of a complex compound with sodium tetraborate. A soft dosage form has been developed with the addition of 10% propylene glycol as a plasticizer and a 0.1% preservative solution. As a result of further studies of the developed soft dosage form, it was revealed that after 6–12 months of storage under natural conditions at a temperature of +20 ± 5°C, the studied gel remained stable. These studies made it possible to use the investigated gel in medicine as a basis for a soft dosage form.

Journal

Russian Journal of Bioorganic Chemistry – Springer Journals

Published: Dec 1, 2021

Keywords: galactomannan; gelling base; sodium tetraborate complex; bridging; crosslinking

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