Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Investigation of possible high-energy phosphate concentration changes in the visual cortex for different stimulus frequencies

Investigation of possible high-energy phosphate concentration changes in the visual cortex for... Purpose Many works have reported changes in the visual cortex regarding stimulation with different flickering frequencies using various neuroimaging techniques. Also, many phosphorus functional magnetic resonance spectroscopy ( P-fMRS) studies have reported high-energy phosphate (HEP) changes in the visual cortex during visual stimulation at 8 Hz, compared with rest periods. However, there have been no studies attempting to measure HEP changes during visual stimulation with different flickering frequencies. The aim of this work was to use the P-fMRS technique to assess possible HEP changes during visual stimulation experiments with stimuli flickering at 4 Hz or 8 Hz, and compare the results obtained with the different frequencies. Methods Nineteen subjects participated in the study. Experiments consisted of P-fMRS acquisitions in a 3T magnetic reso- nance scanner while subjects underwent a five blocks Rest/Stimulus protocol, with stimuli flickering at either 4 Hz or 8 Hz. We assessed pH; the alpha and gamma peaks of adenosine tri-phosphate (α-ATP and γ-ATP); the ratios phosphocreatine/inorganic phosphate (Pi), and of the metabolites phosphocreatine, Pi, glycerophosphocholine, phosphoethanolamine, and glycerophosphoethanolamine with respect to α-ATP and γ-ATP; and the linewidth of the phosphocreatine peak. Results pH was stable along acquisitions for both 4 Hz and 8 Hz. No http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Biomedical Engineering Springer Journals

Investigation of possible high-energy phosphate concentration changes in the visual cortex for different stimulus frequencies

Download PDF
9 pages

Loading next page...
 
/lp/springer-journals/investigation-of-possible-high-energy-phosphate-concentration-changes-cNLXPJ4src
Publisher
Springer Journals
Copyright
Copyright © 2019 by Sociedade Brasileira de Engenharia Biomedica
Subject
Engineering; Biomedical Engineering and Bioengineering; Biomaterials; Biomedical Engineering/Biotechnology
ISSN
2446-4732
eISSN
2446-4740
DOI
10.1007/s42600-019-00023-0
Publisher site
See Article on Publisher Site

Abstract

Purpose Many works have reported changes in the visual cortex regarding stimulation with different flickering frequencies using various neuroimaging techniques. Also, many phosphorus functional magnetic resonance spectroscopy ( P-fMRS) studies have reported high-energy phosphate (HEP) changes in the visual cortex during visual stimulation at 8 Hz, compared with rest periods. However, there have been no studies attempting to measure HEP changes during visual stimulation with different flickering frequencies. The aim of this work was to use the P-fMRS technique to assess possible HEP changes during visual stimulation experiments with stimuli flickering at 4 Hz or 8 Hz, and compare the results obtained with the different frequencies. Methods Nineteen subjects participated in the study. Experiments consisted of P-fMRS acquisitions in a 3T magnetic reso- nance scanner while subjects underwent a five blocks Rest/Stimulus protocol, with stimuli flickering at either 4 Hz or 8 Hz. We assessed pH; the alpha and gamma peaks of adenosine tri-phosphate (α-ATP and γ-ATP); the ratios phosphocreatine/inorganic phosphate (Pi), and of the metabolites phosphocreatine, Pi, glycerophosphocholine, phosphoethanolamine, and glycerophosphoethanolamine with respect to α-ATP and γ-ATP; and the linewidth of the phosphocreatine peak. Results pH was stable along acquisitions for both 4 Hz and 8 Hz. No

Journal

Research on Biomedical Engineering – Springer Journals

Published: Nov 9, 2019

References

  • 31P-MRS using visual stimulation protocols with different durations in healthy young adult subjects
    Barreto, FR; Costa, TBS; Landim, RCG; Castellano, G; Salmon, CEG
  • Imaging of human brain creatine kinase activity in vivo
    Cadoux-Hudson, T; Blackledge, M; Radda, G
  • Increase of creatine kinase activity in the visual cortex of human brain during visual stimulation: a 31P magnetization transfer study
    Chen, W; Zhu, XH; Adriany, G; Ugurbil, K
  • 31P magnetization transfer magnetic resonance spectroscopy: assessing the activation induced change in cerebral ATP metabolic rates at 3 T
    Chen, C; Stephenson, MC; Peters, A; Morris, PG; Francis, ST; Gowland, PA
  • Changes in BOLD transients with visual stimuli across 1–44 Hz
    Emir, UE; Bayraktaroglu, Z; Ozturk, C; Ademoglu, A; Demiralp, T
  • Evaluation of activity-dependent functional pH and T1ρ response in the visual cortex
    Heo, HY; Wemmie, J; Thedens, D; Magnotta, VA
  • Human EEG responses to 1–100 Hz flicker: resonance phenomena in visual cortex and their potential correlation to cognitive phenomena
    Herrmann, CS
  • 1H and 31P spectroscopy and bioenergetics in the lateralization of seizures in temporal lobe epilepsy
    Hetherington, HP; Pan, JW; Spencer, DD
  • High energy phosphate abnormalities normalize after antipsychotic treatment in schizophrenia: a longitudinal 31P MRS study of basal ganglia
    Jayakumar, PN; Gangadhar, BN; Venkatasubramanian, G; Desai, S; Velayudhan, L; Subbakrishna, D; Keshavan, MS
  • Effect of photic stimulation on energy metabolism in the human brain measured by 31P-MR spectroscopy
    Kato, T; Murashita, J; Shioiri, T; Hamakawa, H; Inubushi, T
  • Photic stimulation-induced alteration of brain energy metabolism measured by 31P-MR spectroscopy in patients with MELAS
    Kato, T; Murashita, J; Shioiri, T; Terada, M; Inubushi, T; Kato, N
  • Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex
    Lin, A-L; Fox, PT; Hardies, J; Duong, TQ; Gao, J-H
  • Abnormal response to cortical activation in early stages of Huntington disease
    Mochel, F; N’Guyen, TM; Deelchand, D; Rinaldi, D; Valabregue, R; Wary, C; Carlier, PG; Durr, A; Henry, PG
  • Age-dependent alteration of metabolic response to photic stimulation in the human brain measured by 31P MR-spectroscopy
    Murashita, J; Kato, T; Shioiri, T; Inubushi, T; Kato, N
  • Altered brain energy metabolism in lithium-resistant bipolar disorder detected by photic stimulated 31P-MR spectroscopy
    Murashita, J; Kato, T; Shioiri, T; Inubushi, T; Kato, N
  • Reduced BOLD response to periodic visual stimulation
    Parkes, LM; Fries, P; Kerskens, CM; Norris, DG
  • In vivo31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 T
    Qiao, H; Zhang, X; Zhu, XH; Du, F; Chen, W
  • Energetics of 3.5 s neural activation in humans: a 31P MR spectroscopy study
    Rango, M; Castelli, A; Scarlato, G
  • Brain activation in normal subjects and in patients affected by mitochondrial disease without clinical central nervous system involvement: a phosphorus magnetic resonance spectroscopy study
    Rango, M; Bozzali, M; Prelle, A; Scarlato, G; Bresolin, N
  • Parkinson’s disease and brain mitochondrial dysfunction: a functional phosphorus magnetic resonance spectroscopy study
    Rango, M; Bonifati, C; Bresolin, N
  • Comparison of three reference methods for the measurement of intracellular pH using 31 P MRS in healthy volunteers and patients with lymphoma
    Rata, M; Giles, SL; DeSouza, NM; Leach, MO; Payne, GS
  • Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy
    Sappey-Marinier, D; Calabrese, G; Fein, G; Hugg, JW; Biggins, C; Weiner, MW
  • Normal cortical energy metabolism in migrainous stroke: a 31P-MR spectroscopy study
    Schulz, UG; Blamire, AM; Davies, P; Styles, P; Rothwell, PM
  • In vivo31P NMR spectroscopy shows an increase in glycerophosphorylcholine concentration without alterations in mitochondrial function in the prefrontal cortex of medicated schizophrenic patients at rest
    Shirayama, Y; Yano, T; Takahashi, K; Takahashi, S; Ogino, T
  • Correlation between BOLD-fMRI and EEG signal changes in response to visual stimulus frequency in humans
    Singh, M; Kim, S; Kim, T-S
  • Assessment of 31P-NMR analysis of phospholipid profiles for potential differential diagnosis of human cerebral tumors
    Solivera, J; Cerdán, S; Pascual, JM; Barrios, L; Roda, JM
  • fMRI responses in medial frontal cortex that depend on the temporal frequency of visual input
    Srinivasan, R; Fornari, E; Knyazeva, MG; Meuli, R; Maeder, P
  • Quantitation of magnetic resonance spectroscopy signals: the jMRUI software package
    Stefan, D; Cesare, FD; Andrasescu, A; Popa, E; Lazariev, A; Vescovo, E; Strbak, O; Williams, S; Starcuk, Z; Cabanas, M; Ormondt, D; Graveron-Demilly, D
  • Model of blood–brain transfer of oxygen explains nonlinear flow-metabolism coupling during stimulation of visual cortex
    Vafaee, MS; Gjedde, A
  • Frequency-dependent changes in cerebral metabolic rate of oxygen during activation of human visual cortex
    Vafaee, MS; Meyer, E; Marrett, S; Paus, T; Evans, AC; Gjedde, A
  • Is visual activation associated with changes in cerebral high-energy phosphate levels?
    van de Bank, BL; Maas, MC; Bains, LJ; Heerschap, A; Scheenen, TWJ
  • Improved method for accurate and efficient quantification of MRS data with use of prior knowledge
    Vanhamme, L; Boogaart, A; Huffel, S
  • 31P magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences
    Wijnen, JP; Scheenen, TWJ; Klomp, DWJ; Heerschap, A
  • Observed BOLD effects on cerebral metabolite resonances in human visual cortex during visual stimulation: a functional 1H MRS study at 4 T
    Zhu, X-H; Chen, W
  • A preliminary evaluation of the correlation between regional energy phosphates and resting state functional connectivity in depression
    Zuo, CS; Lin, P; Vitaliano, G; Wang, K; Villafuerte, R; Lukas, SE