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Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal... Purpose As there were few previous studies with a small number of subjects, the purpose of this was to evaluate the prognostic significance of F-FDG PET/CT in patients with distal bile duct cancer undergoing curative surgery. Methods The study included 40 patients (M/F = 24:16; age 68.0 ± 8.0 years) who underwent preoperative F-FDG PET/CT followed by curative surgical resection. The participant’s age, sex, Eastern Cooperative Oncology Group performance-status score, baseline serum CA 19-9 level, stage, pathologic T and N stages, tumor size, tumor grade, tumor growth pattern, R0 resection, and adjuvant therapy were included as clinicopathological variables for predicting overall survival. The PET variables were maximum standardized uptake value (SUV ), average SUV (SUV ), metabolic tumor volume (MTV), and total lesion max avg glycolysis (TLG) of the tumor. The Kaplan-Meyer method and Cox proportional hazards model were used for the survival analysis. Results A total of 15 of 40 patients (37.5%) died during the follow-up period. In univariate analysis, low SUV (≤ 2.7, p = max 0.0005) and low SUV (≤ 2.6, p = 0.0034) were significant predictors of poor overall survival. In multivariate analyses, only avg low SUV (HR = 6.7016, 95% CI 1.9961–22.4993, p = http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nuclear Medicine and Molecular Imaging Springer Journals

Inverse Prognostic Relationships of 18F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Korean Society of Nuclear Medicine
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
ISSN
1869-3474
eISSN
1869-3482
DOI
10.1007/s13139-018-0542-9
Publisher site
See Article on Publisher Site

Abstract

Purpose As there were few previous studies with a small number of subjects, the purpose of this was to evaluate the prognostic significance of F-FDG PET/CT in patients with distal bile duct cancer undergoing curative surgery. Methods The study included 40 patients (M/F = 24:16; age 68.0 ± 8.0 years) who underwent preoperative F-FDG PET/CT followed by curative surgical resection. The participant’s age, sex, Eastern Cooperative Oncology Group performance-status score, baseline serum CA 19-9 level, stage, pathologic T and N stages, tumor size, tumor grade, tumor growth pattern, R0 resection, and adjuvant therapy were included as clinicopathological variables for predicting overall survival. The PET variables were maximum standardized uptake value (SUV ), average SUV (SUV ), metabolic tumor volume (MTV), and total lesion max avg glycolysis (TLG) of the tumor. The Kaplan-Meyer method and Cox proportional hazards model were used for the survival analysis. Results A total of 15 of 40 patients (37.5%) died during the follow-up period. In univariate analysis, low SUV (≤ 2.7, p = max 0.0005) and low SUV (≤ 2.6, p = 0.0034) were significant predictors of poor overall survival. In multivariate analyses, only avg low SUV (HR = 6.7016, 95% CI 1.9961–22.4993, p =

Journal

Nuclear Medicine and Molecular Imaging – Springer Journals

Published: Aug 30, 2018

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