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(2000)
Handbook of vascular brachytherapy
K. Reynen, U. Köckeritz, J. Kropp, G. Wunderlich, F. Knapp, A. Schmeisser, R. Strasser (2004)
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Intravascular brachytherapy has become the standard of care for the treatment of coronary in-stent restenosis after repeat angioplasty. More than 5000 patients have been treated as part of various clinical trials. Based on the results of the GAMMA I trial, the START (90Sr Treatment of Angiographic Restenosis Trial), and the INHIBIT (INtimal Hyperplasia Inhibition with Beta In-stent restenosis Trial), the Checkmate® system using 192Ir, the Betacath® system using 90Sr/Y, and the Galileo® system using 32P; have been approved for the treatment of in-stent restenosis. With a better understanding and application of radiation oncology concepts to vascular brachytherapy, problems such as edge failure are being overcome. The complication of late thrombosis has also become less significant with the elimination of restenting at the brachytherapy procedure, and the prolonged use of antiplatelet therapy. There are other competing modalities in the early phases of clinical trials. The durability of results, lack of any significant long-term complications and the confirmation of the efficacy in other sites will further consolidate the role of radiation in treating in-stent restenosis.
American Journal of Cardiovascular Drugs – Springer Journals
Published: Sep 13, 2012
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