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Inorganic nanoparticles restrict viability of metastatic breast cancer cells in vitro

Inorganic nanoparticles restrict viability of metastatic breast cancer cells in vitro Available cancer therapies are limited due to undesirable side effects, non-specific cellular toxicity as well as treatment failure. Therefore, there is urgent need for newer treatment strategies. In this study, we comparatively determined the in vitro anti-cancer potential of inorganic nanoparticles (NPs) in MDA-MB-231 cancer cells. Flow cytometry, confocal microscopy, and reactive oxygen species (ROS) assays were employed to probe likely mechanism of anti-cancer action of NPs. Study demonstrated dose- dependent toxicity of NPs to MDA-MB-231 cells. The NPs promoted production of ROS and might have caused early apoptotic clearance of MDA-MB-231 cells. Considered together, the findings support anti-cancer potential of inorganic NPs. Furthermore, preliminary evidence suggests that the anti-cancer potential of these NPs may be linked with capacity to cause ROS production as well as cellular apoptosis. Further studies to clearly define the mechanistic cellular actions of these nanoparticles are warranted. . . . Keywords Apoptosis Cellular death Nanomedicine Toxicity Introduction Perhaps, the limitations of available cancer therapies under- score the continuing efforts for exploring available avenue to Aside lung cancer, breast cancer is a leading cause of death in identify better treatment strategy for breast cancer. Lately, the application of nanoparticles (NPs) for biomedical purposes in- women http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Inorganic nanoparticles restrict viability of metastatic breast cancer cells in vitro

Adeyemi, Oluyomi; Otohinoyi, David
Comparative Clinical Pathology , Volume OnlineFirst – Oct 30, 2018
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References (20)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag London Ltd., part of Springer Nature
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-018-2841-z
Publisher site
See Article on Publisher Site

Abstract

Available cancer therapies are limited due to undesirable side effects, non-specific cellular toxicity as well as treatment failure. Therefore, there is urgent need for newer treatment strategies. In this study, we comparatively determined the in vitro anti-cancer potential of inorganic nanoparticles (NPs) in MDA-MB-231 cancer cells. Flow cytometry, confocal microscopy, and reactive oxygen species (ROS) assays were employed to probe likely mechanism of anti-cancer action of NPs. Study demonstrated dose- dependent toxicity of NPs to MDA-MB-231 cells. The NPs promoted production of ROS and might have caused early apoptotic clearance of MDA-MB-231 cells. Considered together, the findings support anti-cancer potential of inorganic NPs. Furthermore, preliminary evidence suggests that the anti-cancer potential of these NPs may be linked with capacity to cause ROS production as well as cellular apoptosis. Further studies to clearly define the mechanistic cellular actions of these nanoparticles are warranted. . . . Keywords Apoptosis Cellular death Nanomedicine Toxicity Introduction Perhaps, the limitations of available cancer therapies under- score the continuing efforts for exploring available avenue to Aside lung cancer, breast cancer is a leading cause of death in identify better treatment strategy for breast cancer. Lately, the application of nanoparticles (NPs) for biomedical purposes in- women

Journal

Comparative Clinical Pathology – Springer Journals

Published: Oct 30, 2018

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