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374 Allergens treated group compared with placebo. However, there was a appears to be more effective in inducing Th1 immune significant increase in IFN-γ mRNA-positive cells in the responses than immunostimulatory sequences (ISS) that mucosa after challenge. The absence of similar change in the were co-administered, but in an unconjugated fashion, preseasonal response to allergen challenge suggests that with Amb a1. additional time or allergen exposure is necessary to achieve The short, 6-week trial of immunotherapy in this popu- benefit from this mode of allergen desensitization. lation showed that there were no significant differences in There was no difference in the mean clinical scores in treated and untreated groups during the first ragweed sea- medication use in the two treatment arms. In the second son, which began a few weeks after the last administration. season, chest symptoms were significantly reduced in the Similarly, there were no significant changes in the response AIC treatment group. The nasal symptoms were somewhat to nasal allergen challenge performed before the beginning lower but did not reach statistical significance. of the season. However, 4 to 5 months after the initial AIC injection, changes in the ragweed Th1 and Th2 responses were Editor’s Comments observed,
Current Allergy and Asthma Reports – Springer Journals
Published: May 30, 2004
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