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Background Positron emission tomography/computed to- PET/CT, PET/MRI resulted in a more definitive interpretation mography (PET/CT) with 2-deoxy-2-[ F]fluoro-D-glucose by facilitating the differentiation of infection/inflammation (FDG) has become the standard of care for the initial staging from malignancy (15/18), the accurate localization of FDG- and subsequent treatment response assessment of many dif- avid lesions (2/18), and the characterization of incidental ferent malignancies. Despite this success, PET/CT is often non-FDG-avid solid organ lesions (1/18). Explanations for supplemented by MRI to improve assessment of local tumor improved reader certainty with PET/MRI included the supe- invasion and to facilitate detection of lesions in organs with rior soft tissue contrast of MRI and the ability to assess cel- high background FDG uptake. Consequently, PET/MRI has lular density with diffusion-weighted imaging. The majority the potential to expand the clinical value of PET examinations (12/18) of such cases had an appropriate standard of refer- by increasing reader certainty and reducing the need for sub- ence; in all 12 cases, the definitive PET/MRI interpretation sequent imaging. This study evaluates the ability of FDG- proved correct. These 12 patients underwent six additional PET/MRI to clarify findings initially deemed indeterminate diagnostic studies to clarify the initial indeterminate PET/ on
Nuclear Medicine and Molecular Imaging – Springer Journals
Published: Feb 22, 2016
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