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Increased Medial TUNEL-positive Staining Associated with Apoptotic Bodies is Linked to Smooth Muscle Cell Diminution during Evolution of Abdominal Aortic Aneurysms

Increased Medial TUNEL-positive Staining Associated with Apoptotic Bodies is Linked to Smooth... Apoptosis has recently been identified as an important process in large vessel structural integrity. We examined whether the size of the abdominal aortic aneurysm might be associated with programmed cell death. We performed in situ labeling of the 3? ends of DNA fragments by apoptosis-associated endonucleases in 20 aneurysms, 10 controls with aortoiliac occlusive disease, and 4 controls with healthy aortas. Antibodies against a-smooth muscle actin were used to quantify smooth muscle cell alterations in the medial layer. Inflammatory cell characterization was made by using four monoclonal mouse antibodies (UCHL1, L26, PG-M1, and KP1). The results confirm the assumption that an apoptotic process may be of consequence for the loss of medial smooth muscle cells in the early evolution of an abdominal aortic aneurysm process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Vascular Surgery Springer Journals

Increased Medial TUNEL-positive Staining Associated with Apoptotic Bodies is Linked to Smooth Muscle Cell Diminution during Evolution of Abdominal Aortic Aneurysms

Annals of Vascular Surgery , Volume 16 (4) – Jul 23, 2002

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 2002 by Annals of Vascular Surgey
Subject
Medicine & Public Health; Abdominal Surgery
ISSN
0890-5096
eISSN
1615-5947
DOI
10.1007/s10016-001-0071-2
pmid
12132024
Publisher site
See Article on Publisher Site

Abstract

Apoptosis has recently been identified as an important process in large vessel structural integrity. We examined whether the size of the abdominal aortic aneurysm might be associated with programmed cell death. We performed in situ labeling of the 3? ends of DNA fragments by apoptosis-associated endonucleases in 20 aneurysms, 10 controls with aortoiliac occlusive disease, and 4 controls with healthy aortas. Antibodies against a-smooth muscle actin were used to quantify smooth muscle cell alterations in the medial layer. Inflammatory cell characterization was made by using four monoclonal mouse antibodies (UCHL1, L26, PG-M1, and KP1). The results confirm the assumption that an apoptotic process may be of consequence for the loss of medial smooth muscle cells in the early evolution of an abdominal aortic aneurysm process.

Journal

Annals of Vascular SurgerySpringer Journals

Published: Jul 23, 2002

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