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Nucl Med Mol Imaging (2013) 47:1–8 DOI 10.1007/s13139-012-0166-4 ORIGINAL ARTICLE In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression Kwang Il Kim & Yong Jin Lee & Tae Sup Lee & Inho Song & Gi Jeong Cheon & Sang Moo Lim & June-Key Chung & Joo Hyun Kang Received: 10 July 2012 /Revised: 10 August 2012 /Accepted: 20 August 2012 /Published online: 6 September 2012 Korean Society of Nuclear Medicine 2012 Abstract and in AFP-nonproducing cells was investigated using I Purpose This study aimed to develop a gene expression uptake assay and semi-quantitative reverse transcription po- targeting method for specific imaging and therapy of lymerase chain reaction (RT-PCR). The killing effect of I alpha-fetoprotein (AFP)-producing hepatocellular carcino- on AdAFPhNIS-infected HCC cells was studied using an in ma (HCC) cells, using an adenovirus vector containing the vitro clonogenic assay. In addition, tumor-bearing mice human sodium/iodide symporter (hNIS) gene driven by an were intravenously injected with the adenovirus, and scinti- AFP enhancer/promoter. graphic images were obtained. Methods The recombinant adenovirus vector, AdAFPhNIS Results The expression of hNIS was efficiently demonstrat- (containing the hNIS gene driven by human AFP enhancer/ ed
Nuclear Medicine and Molecular Imaging – Springer Journals
Published: Sep 6, 2012
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