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In vitro assessment of the haemolytic potential of candidate drugs

In vitro assessment of the haemolytic potential of candidate drugs Several chemicals cause haemolysis when administered to mammals by the intravenous route. From a regulatory point of view there are no recommended methods for assessing the haemolytic potential of candidate drugs. In our laboratory, we routinely investigate the reaction between human (or animal) whole blood and candidate drugs (or their vehicles or metabolites) and measure haemolysis by assaying haemoglobin in the supernatants. Here, we describe this method. This test is inexpensive and requires only few millilitres of whole blood. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

In vitro assessment of the haemolytic potential of candidate drugs

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References (3)

Publisher
Springer Journals
Copyright
Copyright © 1994 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF00368264
Publisher site
See Article on Publisher Site

Abstract

Several chemicals cause haemolysis when administered to mammals by the intravenous route. From a regulatory point of view there are no recommended methods for assessing the haemolytic potential of candidate drugs. In our laboratory, we routinely investigate the reaction between human (or animal) whole blood and candidate drugs (or their vehicles or metabolites) and measure haemolysis by assaying haemoglobin in the supernatants. Here, we describe this method. This test is inexpensive and requires only few millilitres of whole blood.

Journal

Comparative Clinical PathologySpringer Journals

Published: Sep 8, 2004

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