Access the full text.
Sign up today, get DeepDyve free for 14 days.
Hua Yu, D. Grainger (1994)
Amphiphilic Thermosensitive N-Isopropylacrylamide Terpolymer Hydrogels Prepared by Micellar Polymerization in Aqueous MediaMacromolecules, 27
Suming Li (2003)
Bioresorbable Hydrogels Prepared Through Stereocomplexation between Poly(L‐lactide) and Poly(D‐lactide) Blocks Attached to Poly(ethylene glycol)Macromolecular Bioscience, 3
Soyeon Kim, K. Healy (2003)
Synthesis and characterization of injectable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with proteolytically degradable cross-links.Biomacromolecules, 4 5
M. Bae, K. Lee, Yoon‐Jeong Park, D. Mooney (2007)
RGD Island Spacing Controls Phenotype of Primary Human Fibroblasts Adhered to Ligand-Organized HydrogelsMacromolecular Research, 15
A. J. Domb J. Slager (2003)
10.1016/S0169-409X(03)00042-5Adv. Drug Deliver. Rev., 55
Zhimou Yang, G. Liang, Bing Xu (2008)
Enzymatic hydrogelation of small molecules.Accounts of chemical research, 41 2
M. Torres-Lugo, N. Peppas (1999)
Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitoninMacromolecules, 32
S. Jong, S. Smedt, M. Wahls, J. Demeester, ‡. Bosch, W. Hennink (2000)
Novel Self-assembled Hydrogels by Stereocomplex Formation in Aqueous Solution of Enantiomeric Lactic Acid Oligomers Grafted To DextranMacromolecules, 33
Dong Wang, K. Dušek, P. Kopečková, M. Dušková-Smrčková, J. Kopeček (2002)
Novel aromatic azo-containing pH-sensitive hydrogels: Synthesis and characterizationMacromolecules, 35
K. Park, H. Park, Hee Lee, Yong Kim, T. Ooya, N. Yui (2004)
Sulfonated poly(ethylene glycol) containing methacrylate copolymer surfaces; preparation, characterization andin vitro biocompatibilityMacromolecular Research, 12
Sang Park, D. Han, S. Kim (2001)
Synthesis and Characterization of Star-Shaped PLLA-PEO Block Copolymers with Temperature-Sensitive Sol-Gel Transition BehaviorMacromolecules, 34
C. Hiemstra, Z. Zhong, S. Tomme, M. Steenbergen, J. Jacobs, W. Otter, W. Hennink, J. Feijen (2007)
In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)-poly(lactide) hydrogels.Journal of controlled release : official journal of the Controlled Release Society, 119 3
J. Groot, F. Beijma, H. Haitjema, K. Dillingham, K. Hodd, S. Koopmans, S. Norrby (2001)
Injectable intraocular lens materials based upon hydrogels.Biomacromolecules, 2 3
M. Dadsetan, J. Szatkowski, M. Yaszemski, Lichun Lu (2007)
Characterization of photo-cross-linked oligo[poly(ethylene glycol) fumarate] hydrogels for cartilage tissue engineering.Biomacromolecules, 8 5
Lihua Li, S. Ding, Changren Zhou (2004)
Preparation and degradation of PLA/chitosan composite materialsJournal of Applied Polymer Science, 91
D. Karst, Yiqi Yang (2006)
Molecular modeling study of the resistance of PLA to hydrolysis based on the blending of PLLA and PDLAPolymer, 47
Jin Kim, J. Chun, D. Kim, Y. Choi, M. Lee (2002)
Poly(ether-ester) multiblock copolymers based on poly(oxymethylene-alt-oxyalkylene) glycolsMacromolecular Research, 10
Y. Son, Ji‐Heung Kim, Y. Jeon, D. Chung (2007)
Preparation and properties of PEG Modified PNVP hydrogelMacromolecular Research, 15
Su-Jin Im, Y. Choi, E. Subramanyam, K. Huh, Kinam Park (2007)
Synthesis and characterization of biodegradable elastic hydrogels based on poly(ethylene glycol) and poly(ε-caprolactone) blocksMacromolecular Research, 15
M. Lutolf, J. Hubbell (2003)
Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition.Biomacromolecules, 4 3
A. Sarvestani, Xuezhong He, E. Jabbari (2007)
Viscoelastic characterization and modeling of gelation kinetics of injectable in situ cross-linkable poly(lactide-co-ethylene oxide-co-fumarate) hydrogels.Biomacromolecules, 8 2
C. Hiemstra, L. Aa, Z. Zhong, P. Dijkstra, J. Feijen (2007)
Novel in situ forming, degradable dextran hydrogels by Michael addition chemistry : Synthesis, rheology, and degradationMacromolecules, 40
Hsiang-Fa Liang, Min-Hao Hong, R. Ho, C. Chung, Yu-Hsin Lin, Chun-Hung Chen, Hsing‐Wen Sung (2004)
Novel method using a temperature-sensitive polymer (methylcellulose) to thermally gel aqueous alginate as a pH-sensitive hydrogel.Biomacromolecules, 5 5
Ranee Stile, W. Burghardt, K. Healy (1999)
Synthesis and characterization of injectable poly(N-isopropylacrylamide)-based hydrogels that support tissue formation in vitroMacromolecules, 32
S. Jong, W. Dijk-Wolthuis, J. Bosch, P. Schuyl, W. Hennink (1998)
Monodisperse Enantiomeric Lactic Acid Oligomers: Preparation, Characterization, and Stereocomplex FormationMacromolecules, 31
B. Jeong, Y. Bae, D. Lee, S. Kim (1997)
Biodegradable block copolymers as injectable drug-delivery systemsNature, 388
C. Hiemstra, Z. Zhong, Liangbin Li, P. Dijkstra, J. Feijen (2006)
In-situ formation of biodegradable hydrogels by stereocomplexation of PEG-(PLLA)8 and PEG-(PDLA)8 star block copolymers.Biomacromolecules, 7 10
Y. Joung, Jung Lee, K. Park, Seung-Jin Lee (2008)
6-arm PLLA-PEG block copolymers for micelle formation and controlled drug releaseMacromolecular Research, 16
S. Toledano, Richard Williams, V. Jayawarna, R. Ulijn (2006)
Enzyme-triggered self-assembly of peptide hydrogels via reversed hydrolysis.Journal of the American Chemical Society, 128 4
K. Gattás-Asfura, Eric Weisman, F. Andreopoulos, M. Mićić, Bill Muller, S. Sirpal, S. Pham, R. Leblanc (2005)
Nitrocinnamate-functionalized gelatin: synthesis and "smart"hydrogel formation via photo-cross-linking.Biomacromolecules, 6 3
K. Nagahama, Y. Nishimura, Y. Ohya, T. Ouchi (2007)
Impacts of stereoregularity and stereocomplex formation on physicochemical, protein adsorption and cell adhesion behaviors of star-shaped 8-arms poly(ethylene glycol)- : poly(lactide) block copolymer filmsPolymer, 48
A. Bishara, H. Kricheldorf, A. Domb (2005)
Stereocomplexes of Triblock Poly(lactide‐ PEG2000‐lactide) as Carrier of DrugsMacromolecular Symposia, 225
S. Jong, C. Nostrum, L. Kroon-Batenburg, J. Bosch, W. Hennink (2002)
Oligolactate‐grafted dextran hydrogels: Detection of stereocomplex crosslinks by X‐ray diffractionJournal of Applied Polymer Science, 86
Honghyun Park, K. Lee, S. Lee, K. Park, W. Park (2007)
Plasma-treated poly(lactic-co-glycolic acid) nanofibers for tissue engineeringMacromolecular Research, 15
H. Tsuji (2005)
Poly(lactide) stereocomplexes: formation, structure, properties, degradation, and applications.Macromolecular bioscience, 5 7
Jennie Leach, Kathryn Bivens, C. Patrick, C. Schmidt (2003)
Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds.Biotechnology and bioengineering, 82 5
C. Hiemstra, Z. Zhong, P. Dijkstra, J. Feijen (2005)
Stereocomplex Mediated Gelation of PEG‐(PLA)2 and PEG‐(PLA)8 Block CopolymersMacromolecular Symposia, 224
T. Vermonden, N. Fedorovich, D. Geemen, J. Alblas, C. Nostrum, W. Dhert, W. Hennink (2008)
Photopolymerized thermosensitive hydrogels: synthesis, degradation, and cytocompatibility.Biomacromolecules, 9 3
Mariarosaria Tortora, F. Cavalieri, E. Chiessi, G. Paradossi (2007)
Michael-type addition reactions for the in situ formation of poly(vinyl alcohol)-based hydrogels.Biomacromolecules, 8 1
J. Bae, D. Go, K. Park, S. Lee (2006)
Thermosensitive chitosan as an injectable carrier for local drug deliveryMacromolecular Research, 14
N. Shah, M. Pool, A. Metters (2006)
Influence of network structure on the degradation of photo-cross-linked PLA-b-PEG-b-PLA hydrogels.Biomacromolecules, 7 11
E. Ho, A. Lowman, M. Marcolongo (2006)
Synthesis and characterization of an injectable hydrogel with tunable mechanical properties for soft tissue repair.Biomacromolecules, 7 11
Suming Li, A. Ghzaoui, E. Dewinck (2005)
Rheology and Drug Release Properties of Bioresorbable Hydrogels Prepared from Polylactide/Poly(ethylene glycol) Block CopolymersMacromolecular Symposia, 222
Jingxin Lei, Ji‐Heung Kim, Y. Jeon (2008)
Preparation and properties of alginate/polyaspartate composite hydrogelsMacromolecular Research, 16
Xuezhong He, E. Jabbari (2007)
Material properties and cytocompatibility of injectable MMP degradable poly(lactide ethylene oxide fumarate) hydrogel as a carrier for marrow stromal cells.Biomacromolecules, 8 3
D. Ha, Sang Lee, Moo Chong, Y. Lee, So Kim, Young-Hoon Park (2006)
Preparation of thermo-responsive and injectable hydrogels based on hyaluronic acid and poly(N-isopropylacrylamide) and their drug release behaviorsMacromolecular Research, 14
Moon Park, K. Char, H. Kim, Changhee Lee, B. Seong, Young-Soo Han (2002)
Phase behavior of a PEO-PPO-PEO triblock copolymer in aqueous solutions: Two gelation mechanismsMacromolecular Research, 10
W. Shim, Jae Yoo, Y. Bae, D. Lee (2005)
Novel injectable pH and temperature sensitive block copolymer hydrogel.Biomacromolecules, 6 6
Abstract Injectable hydrogels are quite promising materials due to their potential to minimize invasive implantation and this provides versatile fitness irrespective of the damaged regions and facilitates the incorporation of bioactive agents or cells.In situ gel formation through stereocomplex formation is a promising candidate for injectable hydrogels. In this paper, a new series of enantiomeric, four-arm, PEG-PLA block copolymers and their stereocomplexed hydrogels were prepared by bulk ring-opening polymerization of D-lactide and L-lactide, respectively, with stannous octoate as a catalyst. The prepared polymers were characterized by1H nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FT IR) spectroscopy, gel permeation chromatography (GPC) and thermal gravitational analysis (TGA), confirming the tailored structure and chain lengths. The swelling and degradation behavior of the hydrogels formed from a selected copolymer series were observed in different concentrations. The degradation rate decreased with increasing polymer content in the solution. The rheological behavior indicated that the prepared hydrogel underwentin situ gelation and had favorable mechanical strength. In addition, its feasibility as an injectable scaffold was evaluated using a media dependence test for cell culture. A Tris solution was more favorable forin situ gel formation than PBS and DMEM solutions were. These results demonstrated thein situ formation of hydrogel through the construction of a stereocomplex with enantiomeric, 4-arm, PEG-PLA copolymers. Overall, enantiomeric, 4-arm, PEG-PLA copolymers are a new species of stereocomplexed hydrogels that are suitable for further research into injectable hydrogels.
"Macromolecular Research" – Springer Journals
Published: Dec 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.