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Impact of Lymphoid Follicles and Histiocytes on the False-Positive FDG Uptake of Lymph Nodes in Non-Small Cell Lung Cancer

Impact of Lymphoid Follicles and Histiocytes on the False-Positive FDG Uptake of Lymph Nodes in... Nucl Med Mol Imaging (2011) 45:185–191 DOI 10.1007/s13139-011-0085-9 ORIGINAL ARTICLE Impact of Lymphoid Follicles and Histiocytes on the False-Positive FDG Uptake of Lymph Nodes in Non-Small Cell Lung Cancer Seong Young Kwon & Jung-Joon Min & Ho-Chun Song & Chan Choi & Kook-Joo Na & Hee-Seung Bom Received: 17 November 2010 /Revised: 15 April 2011 /Accepted: 18 April 2011 /Published online: 12 May 2011 Korean Society of Nuclear Medicine 2011 Abstract higher than that in group 2. Histologically, the occupied Purpose Although F-fluorodeoxyglucose (FDG) PET/CT proportions of lymphoid follicles (p=0.031) or histiocytes has improved the accuracy of evaluating lymph node (LN) (p=0.004) were higher in group 1. The Glut1 expression of staging in non-small cell lung cancer (NSCLC), false- lymphoid follicles (p=0.035) or histiocytes (p=0.005) was positive results remain a problem. The reason why benign also higher in group 1. LNs show high FDG uptake is still unclear. The aim of this Conclusion Lymphoid follicular hyperplasia and histiocyte study was to identify molecular and pathological character- infiltration associated with Glut1 overexpression are istics of benign LNs showing high FDG uptake. important molecular and pathological mechanisms for Materials and Methods We studied 108 mediastinal LNs of false-positive FDG uptake in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nuclear Medicine and Molecular Imaging Springer Journals

Impact of Lymphoid Follicles and Histiocytes on the False-Positive FDG Uptake of Lymph Nodes in Non-Small Cell Lung Cancer

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References (24)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Korean Society of Nuclear Medicine
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Cardiology; Orthopedics; Oncology
ISSN
1869-3474
eISSN
1869-3482
DOI
10.1007/s13139-011-0085-9
pmid
24900002
Publisher site
See Article on Publisher Site

Abstract

Nucl Med Mol Imaging (2011) 45:185–191 DOI 10.1007/s13139-011-0085-9 ORIGINAL ARTICLE Impact of Lymphoid Follicles and Histiocytes on the False-Positive FDG Uptake of Lymph Nodes in Non-Small Cell Lung Cancer Seong Young Kwon & Jung-Joon Min & Ho-Chun Song & Chan Choi & Kook-Joo Na & Hee-Seung Bom Received: 17 November 2010 /Revised: 15 April 2011 /Accepted: 18 April 2011 /Published online: 12 May 2011 Korean Society of Nuclear Medicine 2011 Abstract higher than that in group 2. Histologically, the occupied Purpose Although F-fluorodeoxyglucose (FDG) PET/CT proportions of lymphoid follicles (p=0.031) or histiocytes has improved the accuracy of evaluating lymph node (LN) (p=0.004) were higher in group 1. The Glut1 expression of staging in non-small cell lung cancer (NSCLC), false- lymphoid follicles (p=0.035) or histiocytes (p=0.005) was positive results remain a problem. The reason why benign also higher in group 1. LNs show high FDG uptake is still unclear. The aim of this Conclusion Lymphoid follicular hyperplasia and histiocyte study was to identify molecular and pathological character- infiltration associated with Glut1 overexpression are istics of benign LNs showing high FDG uptake. important molecular and pathological mechanisms for Materials and Methods We studied 108 mediastinal LNs of false-positive FDG uptake in

Journal

Nuclear Medicine and Molecular ImagingSpringer Journals

Published: May 12, 2011

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