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Nucl Med Mol Imaging (2011) 45:185–191 DOI 10.1007/s13139-011-0085-9 ORIGINAL ARTICLE Impact of Lymphoid Follicles and Histiocytes on the False-Positive FDG Uptake of Lymph Nodes in Non-Small Cell Lung Cancer Seong Young Kwon & Jung-Joon Min & Ho-Chun Song & Chan Choi & Kook-Joo Na & Hee-Seung Bom Received: 17 November 2010 /Revised: 15 April 2011 /Accepted: 18 April 2011 /Published online: 12 May 2011 Korean Society of Nuclear Medicine 2011 Abstract higher than that in group 2. Histologically, the occupied Purpose Although F-fluorodeoxyglucose (FDG) PET/CT proportions of lymphoid follicles (p=0.031) or histiocytes has improved the accuracy of evaluating lymph node (LN) (p=0.004) were higher in group 1. The Glut1 expression of staging in non-small cell lung cancer (NSCLC), false- lymphoid follicles (p=0.035) or histiocytes (p=0.005) was positive results remain a problem. The reason why benign also higher in group 1. LNs show high FDG uptake is still unclear. The aim of this Conclusion Lymphoid follicular hyperplasia and histiocyte study was to identify molecular and pathological character- infiltration associated with Glut1 overexpression are istics of benign LNs showing high FDG uptake. important molecular and pathological mechanisms for Materials and Methods We studied 108 mediastinal LNs of false-positive FDG uptake in
Nuclear Medicine and Molecular Imaging – Springer Journals
Published: May 12, 2011
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