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Impact of Electrical Stimulation on Cortisol Secretion in Rat Adrenal Gland

Impact of Electrical Stimulation on Cortisol Secretion in Rat Adrenal Gland Abstract Cortisol is the primary hormone responsible for the undesirable effects of stress. This study aimed to understand how electrical stimulation influences cortisol secretion, which can be advantageous for designing future implantable electrical devices, to monitor and control the cortisol level. Acutely prepared adrenal gland slices of Sprague-Dawley rats were electrically stimulated at various frequencies, in the presence and absence of adrenocorticotropic hormone (ACTH) and the resultant cortisol levels determined. Electrical stimulation at ≥5 Hz frequency inhibited ACTH-induced cortisol secretion, but electrical stimulation alone did not have any effect. Furthermore, when applied in the presence of TTA-P2, a T-type Ca2+ channel inhibitor, electrical stimulation presented no influence on ACTH-induced cortisol secretion. Our results suggest that the inhibition of the T-type Ca2+ channels by electrical stimulation may contribute to its suppression of cortisol secretion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioChip Journal Springer Journals

Impact of Electrical Stimulation on Cortisol Secretion in Rat Adrenal Gland

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References (22)

Publisher
Springer Journals
Copyright
2018 The Korean BioChip Society and Springer-Verlag GmbH Germany, part of Springer Nature
ISSN
1976-0280
eISSN
2092-7843
DOI
10.1007/s13206-017-2303-8
Publisher site
See Article on Publisher Site

Abstract

Abstract Cortisol is the primary hormone responsible for the undesirable effects of stress. This study aimed to understand how electrical stimulation influences cortisol secretion, which can be advantageous for designing future implantable electrical devices, to monitor and control the cortisol level. Acutely prepared adrenal gland slices of Sprague-Dawley rats were electrically stimulated at various frequencies, in the presence and absence of adrenocorticotropic hormone (ACTH) and the resultant cortisol levels determined. Electrical stimulation at ≥5 Hz frequency inhibited ACTH-induced cortisol secretion, but electrical stimulation alone did not have any effect. Furthermore, when applied in the presence of TTA-P2, a T-type Ca2+ channel inhibitor, electrical stimulation presented no influence on ACTH-induced cortisol secretion. Our results suggest that the inhibition of the T-type Ca2+ channels by electrical stimulation may contribute to its suppression of cortisol secretion.

Journal

BioChip JournalSpringer Journals

Published: Sep 1, 2018

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