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Impact of Breast Cancer Subtypes on Local-Regional Outcomes

Impact of Breast Cancer Subtypes on Local-Regional Outcomes The identification of genomic subtypes of breast cancer nearly 10 years ago provided powerful insight into the genetic heterogeneity of the disease. In the decade since, the concept of tumor biology has been shown to be highly relevant for determining survival outcomes and response to therapy, as well as in explaining variations in the disease noted clinically among women of different ages and races. Establishing tumor subtypes has also driven efforts to identify underlying pathways that drive the biologic phenotype and that can potentially be targeted therapeutically. However, far less is known about the impact of biologic subtypes on local regional outcomes and whether the same subtype specific biologic properties identified in the setting of distant disease can be translated to the local-regional context. In this review, we summarize current research in this area. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Breast Cancer Reports Springer Journals

Impact of Breast Cancer Subtypes on Local-Regional Outcomes

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References (31)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Surgical Oncology; Internal Medicine ; Oncology
ISSN
1943-4588
eISSN
1943-4596
DOI
10.1007/s12609-010-0012-6
Publisher site
See Article on Publisher Site

Abstract

The identification of genomic subtypes of breast cancer nearly 10 years ago provided powerful insight into the genetic heterogeneity of the disease. In the decade since, the concept of tumor biology has been shown to be highly relevant for determining survival outcomes and response to therapy, as well as in explaining variations in the disease noted clinically among women of different ages and races. Establishing tumor subtypes has also driven efforts to identify underlying pathways that drive the biologic phenotype and that can potentially be targeted therapeutically. However, far less is known about the impact of biologic subtypes on local regional outcomes and whether the same subtype specific biologic properties identified in the setting of distant disease can be translated to the local-regional context. In this review, we summarize current research in this area.

Journal

Current Breast Cancer ReportsSpringer Journals

Published: Apr 13, 2010

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