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- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Current Science Inc
- Subject
- Medicine & Public Health; Allergology; Pneumology/Respiratory System; Otorhinolaryngology; Infectious Diseases
- ISSN
- 1529-7322
- eISSN
- 1534-6315
- DOI
- 10.1007/s11882-005-0035-7
- Publisher site
- See Article on Publisher Site
Abstract
Therapeutic strategies based on the use of Immunostimulatory sequences of DNA containing a CpG motif (also known as ISS DNA, or CpG DNA) are focused on minimizing the allergenicity of immunotherapy while improving its effectiveness. Several ISS DNA-based methods of immunization (ISS DNA alone, ISS DNA conjugated to a protein allergen) have shown promise in animal models of asthma, and some of these ISS DNA-based therapies have entered clinical trials. These ongoing clinical trials will help to determine whether any of these ISS DNA-based therapies are safe and effective to use in subjects with allergic rhinitis and asthma.
Journal
Current Allergy and Asthma Reports – Springer Journals
Published: May 27, 2005