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Imaging Findings and Literature Review of 18F-FDG PET/CT in Primary Systemic AL Amyloidosis

Imaging Findings and Literature Review of 18F-FDG PET/CT in Primary Systemic AL Amyloidosis Purpose Although several case reports and case series have take in two-thirds of the organs involving primary systemic described F-FDG PET/CT in amyloidosis, the value of AL amyloidosis, its sensitivity appeared to be low to make F-FDG PET/CT for diagnosing amyloidosis has not been differentiation of pathological uptake from physiological clarified. We investigated the imaging findings of F-FDG uptake. However, due to the small number of cases, fur- PET/CT in patients with primary systemic AL amyloidosis. ther study for the role of F-FDG PET/CT in amyloidosis Methods Subjects were 15 patients (M:F=12:3; age, 61.5± will be warranted. 7.4 years) with histologically confirmed primary systemic . . . AL amyloidosis who underwent pretreatment F-FDG PET/ Keywords F-FDG PET/CT Amyloidosis CT to rule out the possibility of malignancy or for initial Immunoglobulin light chain amyloidosis workup of alleged cancer. For involved organs, visual and semiquantitative analyses were performed on F-FDG PET/ CT images. In total, 22 organs (10 hearts, 5 kidneys, 2 stomachs, Introduction 2 colons, 1 ileum, 1 pancreas, and 1 liver) were histologically confirmed to have primary systemic AL amyloidosis. Amyloidosis refers to extracellular deposition of insoluble Results F-FDG uptake was significantly increased in 15 of polymeric protein fibrils http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nuclear Medicine and Molecular Imaging Springer Journals

Imaging Findings and Literature Review of 18F-FDG PET/CT in Primary Systemic AL Amyloidosis

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References (33)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Korean Society of Nuclear Medicine
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
ISSN
1869-3474
eISSN
1869-3482
DOI
10.1007/s13139-015-0338-0
pmid
26279691
Publisher site
See Article on Publisher Site

Abstract

Purpose Although several case reports and case series have take in two-thirds of the organs involving primary systemic described F-FDG PET/CT in amyloidosis, the value of AL amyloidosis, its sensitivity appeared to be low to make F-FDG PET/CT for diagnosing amyloidosis has not been differentiation of pathological uptake from physiological clarified. We investigated the imaging findings of F-FDG uptake. However, due to the small number of cases, fur- PET/CT in patients with primary systemic AL amyloidosis. ther study for the role of F-FDG PET/CT in amyloidosis Methods Subjects were 15 patients (M:F=12:3; age, 61.5± will be warranted. 7.4 years) with histologically confirmed primary systemic . . . AL amyloidosis who underwent pretreatment F-FDG PET/ Keywords F-FDG PET/CT Amyloidosis CT to rule out the possibility of malignancy or for initial Immunoglobulin light chain amyloidosis workup of alleged cancer. For involved organs, visual and semiquantitative analyses were performed on F-FDG PET/ CT images. In total, 22 organs (10 hearts, 5 kidneys, 2 stomachs, Introduction 2 colons, 1 ileum, 1 pancreas, and 1 liver) were histologically confirmed to have primary systemic AL amyloidosis. Amyloidosis refers to extracellular deposition of insoluble Results F-FDG uptake was significantly increased in 15 of polymeric protein fibrils

Journal

Nuclear Medicine and Molecular Imaging – Springer Journals

Published: May 13, 2015

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